Protein Information

Cytoscape View


UniProt AC / UniProt ID O75030 / MITF_HUMAN
Protein Name Microphthalmia-associated transcription factor
Gene Name Name: MITF
Synonyms:BHLHE32;
Organism Homo sapiens (Human)

PRO ID PR:O75030
DAG View
PRO Name microphthalmia-associated transcription factor (human)
Definition A microphthalmia-associated transcription factor that is encoded in the genome of human.
Short Label hMITF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75030 (MITF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K79 Sumoylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K140 Sumoylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S180 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor   UniProt 10673502
K198 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K289 Sumoylation PRO   PhosphoSitePlus
S301 Phosphorylation RLIMS-P 22046555
K308 Ubiquitination PhosphoSitePlus
R330 Methylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S405 Phosphorylation P49840 (GSK3A) PhosphoSitePlus   Signor   UniProt 10587587
S409 Phosphorylation Q15418 (RPS6KA1) neXtProt   RLIMS-P   Signor 10673502, 14645519, 21749389
S414 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 11792706, ...18220336
K423 Sumoylation PRO   PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus   UniProt 20068231
S502 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus   UniProt 10673502
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 20068231
S68 Phosphorylation HPRD 20068231
S73 Phosphorylation HPRD 20068231
S292 Phosphorylation P49841 (GSK3B) HPRD 10587587
S301 Phosphorylation HPRD 18669648, 20068231
S378 Phosphorylation HPRD 20068231
S391 Phosphorylation HPRD 20068231
S395 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S157 Phosphorylation HPRD 20068231
S175 Phosphorylation HPRD 20068231
S180 Phosphorylation HPRD 20068231
S399 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM 10587587
S408 Phosphorylation HPRD 18669648, 20068231
S485 Phosphorylation HPRD 20068231
S498 Phosphorylation HPRD 20068231
S502 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation HPRD 20068231
S156 Phosphorylation HPRD 20068231
S174 Phosphorylation HPRD 20068231
S179 Phosphorylation HPRD 20068231
S398 Phosphorylation P49841 (GSK3B) HPRD 10587587
S407 Phosphorylation HPRD 18669648, 20068231
S484 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 20068231
S501 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S141 Phosphorylation HPRD 20068231
S159 Phosphorylation HPRD 20068231
S164 Phosphorylation HPRD 20068231
S383 Phosphorylation P49841 (GSK3B) HPRD 10587587
S392 Phosphorylation HPRD 18669648, 20068231
S469 Phosphorylation HPRD 20068231
S482 Phosphorylation HPRD 20068231
S486 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 20068231
S68 Phosphorylation HPRD 20068231
S73 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus 20701798, 9440696, 20068231, ...16246839
K182 Sumoylation PhosphoSitePlus
S298 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) HPRD   PhosphoSitePlus 10587587
S307 Phosphorylation HPRD 18669648, 20068231
K316 Sumoylation PhosphoSitePlus
S384 Phosphorylation HPRD 20068231
S397 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus 25605940, 20068231
S401 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus 25605940, 20068231
S405 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 25605940
S409 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 10673502


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048382 (hMITF/Sumo:1) suK289,suK423 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75030 (MITF) S409 Q9Y6X2 (PIAS3) unknown eFIP 22316093


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K198 N198 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K198 T198 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R330 H330 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
S357 F357 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S504 P504 Biomuta DOID:1793 / pancreatic cancer [ tcga ]