Protein Information

Cytoscape View


UniProt AC / UniProt ID O43776 / SYNC_HUMAN
Protein Name Asparagine--tRNA ligase, cytoplasmic
Gene Name Name: NARS
Organism Homo sapiens (Human)

PRO ID PR:O43776
DAG View
PRO Name asparagine--tRNA ligase, cytoplasmic (human)
Definition An asparagine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hNARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43776 (NARS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S61 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S77 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
R124 Methylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus   UniProt 19608861
K244 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
R451 Methylation PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation HPRD 18669648, 20068231, 17924679
Y393 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 18452278
T459 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 R14 Biomuta DOID:3571 / liver cancer [ icgc ]
S88 I88 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K93 N93 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T253 A253 Biomuta DOID:1612 / breast cancer [ tcga ]
R451 Q451 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K490 T490 Biomuta DOID:1324 / lung cancer [ cosmic ]