iPTMnet Report for O43482 (OIP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43482 / MS18B_HUMAN
Protein Name Protein Mis18-beta
Gene Name Name: OIP5
Synonyms:MIS18B;
Organism Homo sapiens (Human)

PRO ID PR:O43482
DAG View
PRO Name protein Mis18-beta (human)
Definition A protein Mis18-beta that is encoded in the genome of human.
Short Label hOIP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43482 (OIP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 19664995, ...20068231
S48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19664995, 19690332
K175 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K215 Methylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
T221 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19690332, 20068231, ...19664995
S225 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 19651622, ...19690332, 20068231
K226 Methylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q6P0N0 (MIS18BP1) S110 O43482 (OIP5) inhibited_association eFIP 28059702


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 Y47 Biomuta DOID:3571 / liver cancer [ icgc ]
S48 L48 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K195 N195 Biomuta DOID:363 / uterine cancer [ tcga ]
S212 L212 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K215 N215 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]