Protein Information

Cytoscape View

UniProt AC / UniProt ID O43172 / PRP4_HUMAN
Protein Name U4/U6 small nuclear ribonucleoprotein Prp4
Gene Name Name: PRPF4
Organism Homo sapiens (Human)

PRO ID PR:O43172
DAG View
PRO Name U4/U6 small nuclear ribonucleoprotein Prp4 (human)
Definition A U4/U6 small nuclear ribonucleoprotein Prp4 that is encoded in the genome of human.
Short Label hPRPF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O43172 (PRPF4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K15 Sumoylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus   UniProt 19608861
K27 Sumoylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K45 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K159 Sumoylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
R345 Methylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S483 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K147 Q147 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y162 C162 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K284 R284 Biomuta DOID:3070 / malignant glioma [ tcga ]
R345 C345 Biomuta DOID:1324 / lung cancer [ tcga ]
S483 F483 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]