Protein Information

Cytoscape View


UniProt AC / UniProt ID O15516 / CLOCK_HUMAN
Protein Name Circadian locomoter output cycles protein kaput
Gene Name Name: CLOCK
Synonyms:BHLHE8,KIAA0334;
Organism Homo sapiens (Human)

PRO ID PR:O15516
DAG View
PRO Name circadian locomoter output cycles protein kaput (human)
Definition A circadian locomoter output cycles protein kaput that is encoded in the genome of human.
Short Label hCLOCK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15516 (CLOCK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K31 Acetylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S427 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 19946213
T429 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus   RLIMS-P 19946213
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
T451 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P   Signor   UniProt 24235147
S460 Phosphorylation PhosphoSitePlus
T461 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P   Signor   UniProt 24235147
R702 Methylation PhosphoSitePlus
T711 O-Glycosylation GlyGen 23395176, 28657654
S836 Phosphorylation PhosphoSitePlus
K842 Sumoylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046738 (hCLOCK/PhosSer+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 P59 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S164 L164 Biomuta DOID:1324 / lung cancer [ cosmic ]
K418 Q418 Biomuta DOID:1324 / lung cancer [ cosmic ]
S427 R427 Biomuta DOID:3571 / liver cancer [ icgc ]
T429 A429 Biomuta DOID:1612 / breast cancer [ cosmic ]
S431 A431 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S446 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S460 N460 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S460 R460 Biomuta DOID:3571 / liver cancer [ icgc ]
T711 A711 Biomuta DOID:1793 / pancreatic cancer [ tcga ]