Protein Information

Cytoscape View


UniProt AC / UniProt ID O15111 / IKKA_HUMAN
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit alpha
Gene Name Name: CHUK
Synonyms:IKKA,TCF16;
Organism Homo sapiens (Human)

PRO ID PR:O15111
DAG View
PRO Name inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
Definition An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human.
Short Label hCHUK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15111 (CHUK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T23 Phosphorylation Q9Y243 (AKT3) , O00141 (SGK1) , P31751 (AKT2) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12048203, 19609947, 19088076, ...18515365, 10485710
K44 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S119 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
S176 Phosphorylation Q04759 (PRKCQ) , Q99558 (MAP3K14) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9520446, 10195894, 17363905, ...27106634, 9819420, 16286467, 18515365, 22590573
T179 Acetylation PhosphoSitePlus
S180 Phosphorylation Q04759 (PRKCQ) , Q99558 (MAP3K14) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9520446, 10195894, 17363905, ...27106634, 12023051, 9819420, 16286467, 19088076, 18515365, 22590573
K296 Ubiquitination PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S473 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P 17700524
Y500 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S536 Phosphorylation RLIMS-P 17904532, 18161870, 17307160
K569 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
T722 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S176 Phosphorylation PRO
S180 Phosphorylation PRO


O15111 (CHUK) as PTM Enzyme



Substrate Site Score Source PMID
O14920-1 (IKBKB) S177 HPRD 10195894, 10022904, 9689078, ...10779355
O14920-1 (IKBKB) S181 HPRD 10195894, 10022904, 9689078, ...10779355
O43524 (FOXO3) S644 PhosphoSitePlus   Signor 15084260
O75925-1 (PIAS1) S90 HPRD 17540171
P03372 (ESR1) S118 PhosphoSitePlus 15808510
P19838-2 (NFKB1) S922 HPRD 10469655
P19838 (NFKB1) S923 PhosphoSitePlus   Signor 10469655
P19838-2 (NFKB1) S924 HPRD 10469655, 11158290
P19838 (NFKB1) S927 neXtProt   PhosphoSitePlus   Signor 11976329, 11297557, 10469655, ...12482991, 10022904
P19838-2 (NFKB1) S928 HPRD 11976329
P19838 (NFKB1) T931 Signor 10469655
P19838 (NFKB1) S932 PhosphoSitePlus   Signor 12482991, 10469655
P19838-2 (NFKB1) T932 HPRD 10469655
P19838-2 (NFKB1) S933 HPRD 10469655
P24385 (CCND1) T286 PhosphoSitePlus   Signor 16103118
P25963 (NFKBIA) S32 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 9914500, 9244310, 10823818, ...10527519, 9346241, 9252186, 9346484, 11752211
P25963 (NFKBIA) S36 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 9914500, 9244310, 10823818, ...10527519, 9346241, 9252186, 9346484, 11752211
P35222 (CTNNB1) S33 PhosphoSitePlus 12799363
P35222 (CTNNB1) S37 PhosphoSitePlus 12799363
P35222 (CTNNB1) T41 PhosphoSitePlus 12799363
P35222 (CTNNB1) S45 PhosphoSitePlus 12799363
P42345 (MTOR) S1415 PhosphoSitePlus 24990947
P84243 (H3-3B) S11 Signor 12588998
Q00653 (NFKB2) S99 PhosphoSitePlus 15140882
Q00653 (NFKB2) S108 PhosphoSitePlus 15140882
Q00653 (NFKB2) S115 PhosphoSitePlus 15140882
Q00653 (NFKB2) S123 PhosphoSitePlus 15140882
Q00653 (NFKB2) S872 PhosphoSitePlus 15310758, 15140882
Q01094 (E2F1) S403 neXtProt 23796898
Q01201 (RELB) S472 PhosphoSitePlus 25267645
Q04206-1 (RELA) S536 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 12842894, 11359840, 10521409, ...26693062, 15489227, 16382138, 16046471, 15611276
Q04864 (REL) S557 PhosphoSitePlus 17072339
Q14164 (IKBKE) S172 neXtProt 21138416
Q15653-1 (NFKBIB) S19 HPRD 8657102, 9689078
Q15653-1 (NFKBIB) S23 HPRD 8657102, 9689078
Q15717 (ELAVL1) S304 PhosphoSitePlus 23115237
Q5S007 (LRRK2) S910 neXtProt 22723946
Q5S007 (LRRK2) S935 neXtProt 22723946
Q86VP1-2 (TAX1BP1) S593 neXtProt   PhosphoSitePlus 21765415
Q86VP1-2 (TAX1BP1) S624 PhosphoSitePlus 21765415
Q86VP1 (TAX1BP1) S666 neXtProt 21765415
Q92793 (CREBBP) S1382 neXtProt   PhosphoSitePlus   Signor 17434128
Q92793 (CREBBP) S1386 neXtProt   PhosphoSitePlus   Signor 17434128
Q99558 (MAP3K14) T559 Signor 20501937
Q9BUZ4 (TRAF4) S426 neXtProt   PhosphoSitePlus   Signor 22547678
Q9BXH1 (BBC3) S10 PhosphoSitePlus 21997190
Q9NQC7 (CYLD) S418 Signor 24614225
Q9NQC7 (CYLD) S422 Signor 24614225
Q9NQC7 (CYLD) S432 Signor 24614225
Q9NQC7 (CYLD) S436 Signor 24614225
Q9NQC7 (CYLD) S439 Signor 24614225
Q9NQC7 (CYLD) S441 Signor 24614225
Q9NQC7 (CYLD) S444 Signor 24614225
Q9Y261 (FOXA2) S107 neXtProt   PhosphoSitePlus   Signor 22196886
Q9Y261 (FOXA2) S111 neXtProt   PhosphoSitePlus   Signor 22196886
Q9Y618 (NCOR2) S2407 Signor 15494311
Q9Y6Q9-5 (NCOA3) S857 HPRD   PhosphoSitePlus   Signor 19413330, 16964243, 16135815, ...22505454, 15302935, 19651622, 18669648, 15383283, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045576 (hCHUK/Phos:2) pT23 PRO 10485710
PR:000026823 (hCHUK/iso:1/Phos:1) pS176,pS180 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K105 N105 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K366 N366 Biomuta DOID:1612 / breast cancer [ tcga ]
S536 Y536 Biomuta DOID:3070 / malignant glioma [ tcga ]