Protein Information

Cytoscape View

UniProt AC / UniProt ID O14986 / PI51B_HUMAN
Protein Name Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Gene Name Name: PIP5K1B
Organism Homo sapiens (Human)

PRO ID PR:O14986
DAG View
PRO Name phosphatidylinositol 4-phosphate 5-kinase type-1 beta (human)
Definition A phosphatidylinositol 4-phosphate 5-kinase type-1 beta that is encoded in the genome of human.
Short Label hPIP5K1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14986 (PIP5K1B) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y105 Phosphorylation P43405 (SYK) neXtProt   PhosphoSitePlus 19553680
K143 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K301 Methylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S413 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P   Signor 23909401
S421 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S421 L421 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S448 I448 Biomuta DOID:3571 / liver cancer [ icgc ]