Protein Information

Cytoscape View


UniProt AC / UniProt ID O14975 / S27A2_HUMAN
Protein Name Very long-chain acyl-CoA synthetase
Gene Name Name: SLC27A2
Synonyms:ACSVL1,FACVL1,FATP2,VLACS;
Organism Homo sapiens (Human)

PRO ID PR:O14975
DAG View
PRO Name very long-chain acyl-CoA synthetase (human)
Definition A very long-chain acyl-CoA synthetase that is encoded in the genome of human.
Short Label hSLC27A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14975 (SLC27A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S158 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
T225 O-Glycosylation GlyGen 28510447, 29351928
S226 O-Glycosylation GlyGen 28510447, 29351928
K291 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
T577 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K589 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T238 Phosphorylation HPRD 20068231
Y244 Phosphorylation HPRD 20068231
T249 Phosphorylation HPRD 20068231
S252 Phosphorylation HPRD 20068231
T577 Phosphorylation HPRD 20166139, 18669648, 20068231, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S158 L158 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K173 N173 Biomuta DOID:1324 / lung cancer [ tcga ]
S252 G252 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K291 T291 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T393 I393 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K403 N403 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]