PRotein Ontology (PRO) Release 38.0 (15-Oct-2013)

There are 58980 PRO terms
   55 terms are in the 'external' category.
   341 terms are in the 'family' category.
  23575 terms are in the 'gene' category.
  1734 terms are in the 'sequence' category.
  6620 terms are in the 'modification' category.
   181 terms are in the 'complex' category.
    9 terms are in the 'organism-family' category.
  23775 terms are in the 'organism-gene' category.
   787 terms are in the 'organism-sequence' category.
  1368 terms are in the 'organism-modification' category.
   321 terms are in the 'organism-complex' category.
   19 terms are in the 'union' category.
2009 terms have some kind of annotation, codifying the information from 1293 papers.
  3196 connections to GO (1140 PRO terms).
   374 connections to MOD (331 PRO terms).
   617 connections to Pfam (371 PRO terms).
   338 connections to SO (317 PRO terms).
   344 annotations of a phenotype (337 PRO terms).

The ontology includes a subset of terms from other ontologies and resources that are used for logical definitions.

_Current changes_

1) The relationship between an organism-gene class and the gene coding for proteins of that class is made explicit using the has_gene_template relation. For example:

[Term]
id: PR:P51946
alt_id: PR:000027293
name: cyclin-H (human)
def: "A cyclin-H that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "hCCNH" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P51946
intersection_of: PR:000005130 ! cyclin-H
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_gene_template HGNC ! CCNH

This applies only to those organisms with a dedicated model
organism database that curates genes and gene nomenclature.

_Forthcoming changes_

_Ongoing_

1) Continue to add shorthand labels to terms.

2) Continue to expand the set of mapped terms.

3) Resolve names and synonym duplicates.