TI - Neurabin Contributes to Hippocampal Long-Term Potentiation and Contextual Fear Memory Neurabin in LTP and Memory . AB - Neurabin is a scaffolding protein that interacts with actin and protein phosphatase-1 . Highly enriched in the dendritic spine , neurabin is important for spine morphogenesis and synaptic formation . However , less is known about the role of neurabin in hippocampal plasticity and its possible effect on behavioral functions . Using neurabin knockout ( KO ) mice , here we studied the function of neurabin in hippocampal synaptic transmission , plasticity and behavioral memory . We demonstrated that neurabin KO mice showed a deficit in contextual fear memory but not auditory fear memory . Whole cell patch clamp recordings in the hippocampal CA1 neurons showed that long-term potentiation ( LTP ) was significantly reduced , whereas long-term depression ( LTD ) was unaltered in neurabin KO mice . Moreover , increased AMPA receptor was found in neurabin KO mice , and is accompanied by decreased PHOSphorylation of GluR1 at the PKA site (Ser845) but no change at the CaMKII/PKC site (Ser831) . Pre-conditioning with LTD induction rescued the following LTP in neurabin KO mice , suggesting the loss of LTP may be due to the saturated synaptic transmission . Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons .