PR:000000473	smad2 sequence variant D450E (human)	hSMAD2/var:D450E|smad2 sequence variant 4 (human)|UniProtKB:Q15796-1, Asp-450, CHEBI:29972		associated_with_disease_progression	DOID:5672	large intestine cancer			PMID:8752209	EXP	NCBITaxon:9606		UniProtKB_VAR:VAR_011379	20080301	PRO:CNA	
PR:000000473	smad2 sequence variant D450E (human)	hSMAD2/var:D450E|smad2 sequence variant 4 (human)|UniProtKB:Q15796-1, Asp-450, CHEBI:29972	NOT	capable_of	GO:0003713	transcription coactivator activity			PMID:8752209	EXP	NCBITaxon:9606		UniProtKB_VAR:VAR_011379	20080301	PRO:CNA