PR:000000064	TGF-beta receptor type-2 sequence variant S449F (human)	hTGFBR2/var:S449F|TGF-beta receptor type-2 sequence variant 8 (human)|UniProtKB:P37173-1, Ser-449, CHEBI:29997	NOT	capable_of	GO:0005026	transforming growth factor beta receptor activity, type II			PMID:15235604	EXP	NCBITaxon:9606		UniProtKB_VAR:VAR_022358	20080301	PRO:CNA	
PR:000000064	TGF-beta receptor type-2 sequence variant S449F (human)	hTGFBR2/var:S449F|TGF-beta receptor type-2 sequence variant 8 (human)|UniProtKB:P37173-1, Ser-449, CHEBI:29997		associated_with_disease_progression	DOID:0050466	Loeys-Dietz syndrome			PMID:15235604	EXP	NCBITaxon:9606		UniProtKB_VAR:VAR_022358	20080301	PRO:CNA