PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II has_part Pfam:PF08917 Transforming growth factor beta receptor 2 ectodomain PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II capable_of GO:0005515 protein binding PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II capable_of GO:0004672 protein kinase activity PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II participates_in GO:0006468 protein phosphorylation PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II participates_in GO:0042127 regulation of cell population proliferation PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000005 TGF-beta receptor type-2 TbetaR-II|TGF-beta receptor type II|TGF-beta type II receptor|TGFBR2|TGFR-2|transforming growth factor-beta receptor type II has_part Pfam:PF00069 Protein kinase domain PIRSF:PIRSF037393 ISS PIRSF:PIRSF037393 PIRSF:PIRSF037393|UniProtKB:P37173|UniProtKB:Q62312 20080301 PRO:CNA PR:000000050 TGF-beta receptor type-2 sequence variant L308P (human) hTGFBR2/var:L308P|TGF-beta receptor type-2 sequence variant 1 (human)|UniProtKB:P37173-1, Leu-308, CHEBI:50342 NOT capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022351 20080301 PRO:CNA PR:000000050 TGF-beta receptor type-2 sequence variant L308P (human) hTGFBR2/var:L308P|TGF-beta receptor type-2 sequence variant 1 (human)|UniProtKB:P37173-1, Leu-308, CHEBI:50342 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022351 20080301 PRO:CNA PR:000000051 TGF-beta receptor type-2 sequence variant R460H (human) hTGFBR2/var:R460H|TGF-beta receptor type-2 sequence variant 10 (human)|UniProtKB:P37173-1, Arg-460, CHEBI:29979 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_029761 20080301 PRO:CNA PR:000000052 TGF-beta receptor type-2 sequence variant R460C (human) hTGFBR2/var:R460C|TGF-beta receptor type-2 sequence variant 11 (human)|UniProtKB:P37173-1, Arg-460, CHEBI:29950 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_029760 20080301 PRO:CNA PR:000000053 TGF-beta receptor type-2 sequence variant E526Q (human) hTGFBR2/var:E526Q|TGF-beta receptor type-2 sequence variant 12 (human)|UniProtKB:P37173-1, Glu-526, CHEBI:30011 NOT capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:10789724 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_015816 20080301 PRO:CNA PR:000000053 TGF-beta receptor type-2 sequence variant E526Q (human) hTGFBR2/var:E526Q|TGF-beta receptor type-2 sequence variant 12 (human)|UniProtKB:P37173-1, Glu-526, CHEBI:30011 associated_with_disease_progression DOID:3748 esophagus squamous cell carcinoma PMID:10789724 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_015816 20080301 PRO:CNA PR:000000054 TGF-beta receptor type-2 sequence variant R528C (human) hTGFBR2/var:R528C|TGF-beta receptor type-2 sequence variant 13 (human)|UniProtKB:P37173-1, Arg-528, CHEBI:29950 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022360 20080301 PRO:CNA PR:000000055 TGF-beta receptor type-2 sequence variant R528H (human) hTGFBR2/var:R528H|TGF-beta receptor type-2 sequence variant 14 (human)|UniProtKB:P37173-1, Arg-528, CHEBI:29979 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022361 20080301 PRO:CNA PR:000000056 TGF-beta receptor type-2 sequence variant R537C (human) hTGFBR2/var:R537C|TGF-beta receptor type-2 sequence variant 15 (human)|UniProtKB:P37173-1, Arg-537, CHEBI:29950 NOT capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022362 20080301 PRO:CNA PR:000000056 TGF-beta receptor type-2 sequence variant R537C (human) hTGFBR2/var:R537C|TGF-beta receptor type-2 sequence variant 15 (human)|UniProtKB:P37173-1, Arg-537, CHEBI:29950 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022362 20080301 PRO:CNA PR:000000057 TGF-beta receptor type-2 sequence variant G357W (human) hTGFBR2/var:G357W|TGF-beta receptor type-2 sequence variant 16 (human)|UniProtKB:P37173-1, Gly-357, CHEBI:29954 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022354 20080301 PRO:CNA PR:000000058 TGF-beta receptor type-2 sequence variant T315M (human) hTGFBR2/var:T315M|TGF-beta receptor type-2 sequence variant 2 (human)|UniProtKB:P37173-1, Thr-315, CHEBI:16044 associated_with_disease_progression DOID:3883 Lynch syndrome PMID:9590282 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_008156 20080301 PRO:CNA PR:000000058 TGF-beta receptor type-2 sequence variant T315M (human) hTGFBR2/var:T315M|TGF-beta receptor type-2 sequence variant 2 (human)|UniProtKB:P37173-1, Thr-315, CHEBI:16044 participates_in GO:0008284 positive regulation of cell population proliferation PMID:9590282 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_008156 20080301 PRO:CNA PR:000000059 TGF-beta receptor type-2 sequence variant Y336N (human) hTGFBR2/var:Y336N|TGF-beta receptor type-2 sequence variant 3 (human)|UniProtKB:P37173-1, Tyr-336, CHEBI:50347 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022352 20080301 PRO:CNA PR:000000060 TGF-beta receptor type-2 sequence variant A355P (human) hTGFBR2/var:A355P|TGF-beta receptor type-2 sequence variant 4 (human)|UniProtKB:P37173-1, Ala-355, CHEBI:50342 located_in GO:0016021 integral component of membrane PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022353 20080301 PRO:CNA PR:000000060 TGF-beta receptor type-2 sequence variant A355P (human) hTGFBR2/var:A355P|TGF-beta receptor type-2 sequence variant 4 (human)|UniProtKB:P37173-1, Ala-355, CHEBI:50342 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022353 20080301 PRO:CNA PR:000000060 TGF-beta receptor type-2 sequence variant A355P (human) hTGFBR2/var:A355P|TGF-beta receptor type-2 sequence variant 4 (human)|UniProtKB:P37173-1, Ala-355, CHEBI:50342 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:15731757 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022353 20080301 PRO:CNA PR:000000061 TGF-beta receptor type-2 sequence variant V387M (human) hTGFBR2/var:V387M|TGF-beta receptor type-2 sequence variant 5 (human)|UniProtKB:P37173-1, Val-387, CHEBI:16044 located_in GO:0016021 integral component of membrane PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022355 20080301 PRO:CNA PR:000000061 TGF-beta receptor type-2 sequence variant V387M (human) hTGFBR2/var:V387M|TGF-beta receptor type-2 sequence variant 5 (human)|UniProtKB:P37173-1, Val-387, CHEBI:16044 decreased capable_of GO:0005026 transforming growth factor beta receptor activity, type II PR:000000409 PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022355 20080301 PRO:CNA PR:000000061 TGF-beta receptor type-2 sequence variant V387M (human) hTGFBR2/var:V387M|TGF-beta receptor type-2 sequence variant 5 (human)|UniProtKB:P37173-1, Val-387, CHEBI:16044 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022355 20080301 PRO:CNA PR:000000062 TGF-beta receptor type-2 sequence variant N435S (human) hTGFBR2/var:N435S|TGF-beta receptor type-2 sequence variant 6 (human)|UniProtKB:P37173-1, Asn-435, CHEBI:29999 decreased capable_of GO:0005026 transforming growth factor beta receptor activity, type II PR:000000409 PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022356 20080301 PRO:CNA PR:000000062 TGF-beta receptor type-2 sequence variant N435S (human) hTGFBR2/var:N435S|TGF-beta receptor type-2 sequence variant 6 (human)|UniProtKB:P37173-1, Asn-435, CHEBI:29999 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022356 20080301 PRO:CNA PR:000000063 TGF-beta receptor type-2 sequence variant V447A (human) hTGFBR2/var:V447A|TGF-beta receptor type-2 sequence variant 7 (human)|UniProtKB:P37173-1, Val-447, CHEBI:46217 located_in GO:0016021 integral component of membrane PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022357 20080301 PRO:CNA PR:000000063 TGF-beta receptor type-2 sequence variant V447A (human) hTGFBR2/var:V447A|TGF-beta receptor type-2 sequence variant 7 (human)|UniProtKB:P37173-1, Val-447, CHEBI:46217 decreased capable_of GO:0005026 transforming growth factor beta receptor activity, type II PR:000000409 PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022357 20080301 PRO:CNA PR:000000063 TGF-beta receptor type-2 sequence variant V447A (human) hTGFBR2/var:V447A|TGF-beta receptor type-2 sequence variant 7 (human)|UniProtKB:P37173-1, Val-447, CHEBI:46217 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022357 20080301 PRO:CNA PR:000000064 TGF-beta receptor type-2 sequence variant S449F (human) hTGFBR2/var:S449F|TGF-beta receptor type-2 sequence variant 8 (human)|UniProtKB:P37173-1, Ser-449, CHEBI:29997 NOT capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022358 20080301 PRO:CNA PR:000000064 TGF-beta receptor type-2 sequence variant S449F (human) hTGFBR2/var:S449F|TGF-beta receptor type-2 sequence variant 8 (human)|UniProtKB:P37173-1, Ser-449, CHEBI:29997 associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022358 20080301 PRO:CNA PR:000000065 TGF-beta receptor type-2 sequence variant L452M (human) hTGFBR2/var:L452M|TGF-beta receptor type-2 sequence variant 9 (human)|UniProtKB:P37173-1, Leu-452, CHEBI:16044 decreased capable_of GO:0005026 transforming growth factor beta receptor activity, type II PR:000000409 PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022359 20080301 PRO:CNA PR:000000065 TGF-beta receptor type-2 sequence variant L452M (human) hTGFBR2/var:L452M|TGF-beta receptor type-2 sequence variant 9 (human)|UniProtKB:P37173-1, Leu-452, CHEBI:16044 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022359 20080301 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 capable_of GO:0005515 protein binding PR:000000616 PMID:1310899 IPI NCBITaxon:9606 UniProtKB:P37173-1 20090303 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 capable_of GO:0005515 protein binding PR:000000634 PMID:1850637 IPI NCBITaxon:9606 UniProtKB:P37173-1 20080301 PRO:CNA Note=The binding is shown to the ectodomain. The form is inferred by curator. PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 located_in GO:0016021 integral component of membrane PMID:1310899 TAS NCBITaxon:9606 UniProtKB:P37173-1 20080301 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:11483955 TAS NCBITaxon:9606 UniProtKB:P37173-1 20080301 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 participates_in GO:0007181 transforming growth factor beta receptor complex assembly PMID:1310899|PMID:8774881 IC NCBITaxon:9606 PMID:1310899|PMID:8774881 UniProtKB:P37173-1 20080301 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 capable_of GO:0050431 transforming growth factor beta binding PMID:11850637|PMID:1310899 IC NCBITaxon:9606 PMID:11850637|PMID:1310899 UniProtKB:P37173-1 20080301 PRO:CNA PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human) hTGFBR2/iso:1/SigPep-|hTGFBR2/iso:RII-1/SigPep-|PRO_0000024426|TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)|UniProtKB:P37173-1, 23-567 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11483955 TAS NCBITaxon:9606 UniProtKB:P37173-1 20080301 PRO:CNA PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human) hTGFBR2/iso:RII-2|TGF-beta receptor type-2 isoform 2 (human)|TGFBR2 isoform 2 (human) capable_of GO:0005026 transforming growth factor beta receptor activity, type II PMID:7959019|PMID:8635485 EXP NCBITaxon:9606 UniProtKB:P37173-2 20080301 PRO:CNA PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human) hTGFBR2/iso:RII-2|TGF-beta receptor type-2 isoform 2 (human)|TGFBR2 isoform 2 (human) capable_of GO:0050431 transforming growth factor beta binding PMID:8635485 EXP NCBITaxon:9606 UniProtKB:P37173-2 20080301 PRO:CNA PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human) hTGFBR2/iso:RII-2|TGF-beta receptor type-2 isoform 2 (human)|TGFBR2 isoform 2 (human) participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:7959019|PMID:8635485 EXP NCBITaxon:9606 UniProtKB:P37173-2 20080301 PRO:CNA PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human) hTGFBR2/iso:RII-2|TGF-beta receptor type-2 isoform 2 (human)|TGFBR2 isoform 2 (human) participates_in GO:0008284 positive regulation of cell population proliferation PMID:7959019 EXP NCBITaxon:9606 UniProtKB:P37173-2 20080301 PRO:CNA