[Term]
id: PR:000045488
name: interferon regulatory factor 3 phosphorylated 1 (human)
def: "An interferon regulatory factor 3 (human) that has been phosphorylated in Ser and Thr residues within the two phosphorylation cluster sites. A Ser (Ser-386 in UniProtKB:Q14653-1) on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405 in UniProtKB:Q14653-1). Example: UniProtKB:Q14653-1, Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047." [PRO:CNA, Reactome:R-HSA-166258, Reactome:R-HSA-177654]
comment: Category=organism-modification.
synonym: "hIRF3/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "p-4S,T404-IRF3 (human)" RELATED []
synonym: "UniProtKB:Q14653-1, Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
disjoint_from: PR:Q14653-3 ! interferon regulatory factor 3 isoform h3 (human)
disjoint_from: PR:Q14653-4 ! interferon regulatory factor 3 isoform h4 (human)
disjoint_from: PR:Q14653-5 ! interferon regulatory factor 3 isoform h5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens