[Term]
id: PR:000037955
name: histone H2A type 2-A
def: "A histone H2A that is a translation product of the human HIST2H2AA3 or HIST2H2AA4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The human HIST2H2AA3 and HIST2H2AA4 genes encode identical proteins.
synonym: "H2AFA" RELATED []
synonym: "H2AFO" RELATED Gene-based []
synonym: "H2AC18" RELATED Gene-based []
synonym: "H2AC19" RELATED Gene-based []
synonym: "HIST1H2A" EXACT PRO-short-label [PRO:DNx]
synonym: "HIST2H2AA" RELATED Gene-based []
synonym: "HIST2H2AA3" RELATED Gene-based []
synonym: "HIST2H2AA4" RELATED Gene-based []
synonym: "histone H2A.2" BROAD [PRO:DNx]
synonym: "histone H2A/o" EXACT []
is_a: PR:000027547 ! histone H2A

[Term]
id: PR:Q6FI13
name: histone H2A type 2-A (human)
def: "A histone H2A type 2-A that is encoded in the genome of human." [PRO:DAN, UniProtKB:Q6FI13]
comment: Category=organism-gene. Note: The HIST2H2AA3 and HIST2H2AA4 genes encode identical proteins.
synonym: "H2AFO" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "H2AC18" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "H2AC19" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "HIST2H2AA" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "hHIST1H2A" EXACT PRO-short-label [PRO:DNx]
synonym: "HIST2H2AA3" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "HIST2H2AA4" RELATED Gene-based [UniProtKB:Q6FI13]
synonym: "histone H2A.2 (human)" BROAD [UniProtKB:Q6FI13]
synonym: "histone H2A/o (human)" EXACT [UniProtKB:Q6FI13]
synonym: "H2A-clustered histone 18 (human)" EXACT [UniProtKB:Q6FI13]
synonym: "H2A-clustered histone 19 (human)" EXACT [UniProtKB:Q6FI13]
xref: UniProtKB:Q6FI13
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037955 ! histone H2A type 2-A
relationship: has_gene_template HGNC:29668 ! HIST2H2AA4 (human)
relationship: has_gene_template HGNC:4736 ! HIST2H2AA3 (human)

[Term]
id: PR:000044974
name: histone H2A type 2-A, initiator methionine removed acetylated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK5ac" BROAD [HIstome_ptm_Hs:H2AK5ac]
synonym: "hHIST1H2A/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568606 "PR:000044974 located_in GO:0005654"
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044975
name: histone H2A type 2-A, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been ubiquitinated at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK119ub" BROAD [HIstome_ptm_Hs:H2AK119ub]
synonym: "hHIST1H2A/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-120, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-120, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782525 "PR:000044975 located_in GO:0005654"
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044976
name: histone H2A type 2-A, initiator methionine removed phosphorylated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:15010469, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AS1ph" BROAD [HIstome_ptm_Hs:H2AS1ph]
synonym: "hHIST1H2A/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:12331
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044977
name: histone H2A type 2-A, initiator methionine removed biotinylated 2 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-14, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK13bio" BROAD [HIstome_ptm_Hs:H2AK13bio]
synonym: "hHIST1H2A/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-14, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-14, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044971
name: histone H2A type 2-A, initiator methionine removed biotinylated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-130 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-130, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK129bio" BROAD [HIstome_ptm_Hs:H2AK129bio]
synonym: "hHIST1H2A/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-130, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-130, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044972
name: histone H2A type 2-A, initiator methionine removed citrullinated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:15823041, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AR3ci" BROAD [HIstome_ptm_Hs:H2AR3ci]
synonym: "hHIST1H2A/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044973
name: histone H2A type 2-A, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-14, MOD:01399." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK13ar" BROAD [HIstome_ptm_Hs:H2AK13ar]
synonym: "hHIST1H2A/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-14, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-14, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044981
name: histone H2A type 2-A, initiator methionine removed biotinylated 4 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-126 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-126, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK125bio" BROAD [HIstome_ptm_Hs:H2AK125bio]
synonym: "hHIST1H2A/InitMet-/Btn:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-126, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-126, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044980
name: histone H2A type 2-A, initiator methionine removed dimethylated 1 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:18079182, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AR3me2" BROAD [HIstome_ptm_Hs:H2AR3me2]
synonym: "hHIST1H2A/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044983
name: histone H2A type 2-A, initiator methionine removed phosphorylated 2 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-121 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Thr-121, MOD:00047." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:19965387, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AT120ph" BROAD [HIstome_ptm_Hs:H2AT120ph]
synonym: "hHIST1H2A/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Thr-121, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Thr-121, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044982
name: histone H2A type 2-A, initiator methionine removed biotinylated 5 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-128 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-128, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK127bio" BROAD [HIstome_ptm_Hs:H2AK127bio]
synonym: "hHIST1H2A/InitMet-/Btn:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-128, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-128, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044978
name: histone H2A type 2-A, initiator methionine removed acetylated 2 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK9ac" BROAD [HIstome_ptm_Hs:H2AK9ac]
synonym: "hHIST1H2A/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-10, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044979
name: histone H2A type 2-A, initiator methionine removed biotinylated 3 (human)
def: "A histone H2A type 2-A (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:Q6FI13. UniProtKB:Q6FI13, 2-130, Lys-10, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-A, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_2-A:H2AK9bio" BROAD [HIstome_ptm_Hs:H2AK9bio]
synonym: "hHIST1H2A/InitMet-/Btn:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055232, Lys-10, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q6FI13, 2-130, Lys-10, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q6FI13 ! histone H2A type 2-A (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine