[Term]
id: PR:000037303
name: viral dsRNA:TLR3 complex (human)
def: "A viral dsRNA:TLR3 complex whose components are encoded in the genome of human." [PMID:18172197, PMID:19595807, PRO:VS, Reactome:R-HSA-167985]
comment: Category=organism-complex. Requested by=TLR. Note: Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.
synonym: "h(vir)dsRNA:TLR3" EXACT PRO-short-label [PRO:DAN]
xref: Reactome:R-HSA-167985 "PR:000037303 located_in GO:0010008"
is_a: PR:000037302 ! viral dsRNA:TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)