[Term]
id: PR:000036822
name: E protein
def: "A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160." [PMID:17459925, PMID:23300717, PRO:DAN, PRO:ES]
comment: Category=modification. Requested by=IDODEN. The E protein is responsible for eliciting the majority of the protective dengue virus antibody response. It covers the virion surface arranged in anti-parallel dimers containing three structural and antigenic domains [PMID:22709350, PRO:ES].
synonym: "DenV-E" EXACT PRO-short-label [PRO:DAN]
synonym: "Envelope protein E" EXACT []
intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine
intersection_of: derives_from PR:000036817 ! dengue virus genome polyprotein, N-glycosylated form
intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product
intersection_of: lacks_part PR:000036836 ! C-prM
intersection_of: lacks_part PR:000036838 ! NS12345