[Term]
id: PR:000036135
name: TIRAP:PIP2:activated TLR4 complex (human)
def: "A TIRAP:PIP2:activated TLR4 complex that contains phosphatidyl inositol bisphosphate bound to TIRAP/Mal in human." [Reactome:R-HSA-2559411]
comment: Category=organism-complex. Requested by=TLR.
synonym: "Mal:activated TLR4 complex (human)" EXACT [Reactome:R-HSA-2559411]
is_a: PR:000036078 ! TIRAP:PIP2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human)
relationship: has_component PR:P58753-1 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)