[Term]
id: PR:000036045
name: IRF3:XPO1 complex (human)
def: "An IRF3:XPO1 complex whose components are encoded in the genome of human. Exportin-1 recognizes the NES sequence (ILDELLGNMVL) and maintaints IRF-3 in the cytoplasm." [PMID:10805757, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "IRF3pIRF3pQip1 human" BROAD [PRO:DNx]
synonym: "IRF3pIRF3pIMP4alpha human" BROAD [PRO:DNx]
is_a: PR:000036044 ! IRF3:XPO1 complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:O14980 ! exportin-1 (human)
relationship: has_component PR:Q14653 ! interferon regulatory factor 3 (human)

[Term]
id: PR:000036044
name: IRF3:XPO1 complex
def: "A protein-containing complex that is composed of a dimer of phosphorylated IRF-3 bound to exportin-1 (via recognition of the NES sequence). This binding keeps the complex in the cytoplasm." [TLR:AMM]
comment: Category=complex.
synonym: "RF3pIRF3pCRM1" EXACT []
synonym: "IRF3-P:IRF3-P:CRM1" EXACT []
is_a: GO:0032991 ! protein-containing complex