[Term]
id: PR:Q8IWT6-1
name: volume-regulated anion channel subunit LRRC8A isoform 1 (human)
def: "A volume-regulated anion channel subunit LRRC8A isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hLRRC8A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWT6-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000041715 ! volume-regulated anion channel subunit LRRC8A isoform 1

[Term]
id: PR:Q80WG5
name: volume-regulated anion channel subunit LRRC8A (mouse)
def: "A volume-regulated anion channel subunit LRRC8A that is encoded in the genome of mouse." [OMA:Q80WG5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Lrrc8" RELATED Gene-based [UniProtKB:Q80WG5]
synonym: "Lrrc8a" RELATED Gene-based [UniProtKB:Q80WG5]
synonym: "mLRRC8A" EXACT PRO-short-label [PRO:DNx]
synonym: "ebo (mouse)" EXACT [UniProtKB:Q80WG5]
synonym: "protein ebouriffe (mouse)" EXACT [UniProtKB:Q80WG5]
synonym: "leucine-rich repeat-containing protein 8A (mouse)" EXACT [UniProtKB:Q80WG5]
xref: UniProtKB:Q80WG5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000030752 ! volume-regulated anion channel subunit LRRC8A
relationship: has_gene_template MGI:2652847 ! Lrrc8a (mouse)

[Term]
id: PR:Q80WG5-1
name: volume-regulated anion channel subunit LRRC8A isoform 1 (mouse)
def: "A volume-regulated anion channel subunit LRRC8A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mLRRC8A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q80WG5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000041715 ! volume-regulated anion channel subunit LRRC8A isoform 1

[Term]
id: PR:000030752
name: volume-regulated anion channel subunit LRRC8A
def: "A protein that is a translation product of the human LRRC8A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "LRRC8" RELATED Gene-based []
synonym: "LRRC8A" EXACT PRO-short-label [PRO:DNx]
synonym: "SWELL1" RELATED Gene-based []
synonym: "KIAA1437" RELATED Gene-based []
synonym: "UNQ221/PRO247" RELATED Gene-based []
synonym: "leucine-rich repeat-containing protein 8A" EXACT [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:000041715
name: volume-regulated anion channel subunit LRRC8A isoform 1
def: "A volume-regulated anion channel subunit LRRC8A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWT6-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "LRRC8A/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000030752 ! volume-regulated anion channel subunit LRRC8A

[Term]
id: PR:Q4V8I7
name: volume-regulated anion channel subunit LRRC8A (rat)
def: "A volume-regulated anion channel subunit LRRC8A that is encoded in the genome of rat." [OMA:Q4V8I7, PRO:DNx]
comment: Category=organism-gene.
synonym: "Lrrc8" RELATED Gene-based [UniProtKB:Q4V8I7]
synonym: "Lrrc8a" RELATED Gene-based [UniProtKB:Q4V8I7]
synonym: "rLRRC8A" EXACT PRO-short-label [PRO:DNx]
synonym: "leucine-rich repeat-containing protein 8A (rat)" EXACT [UniProtKB:Q4V8I7]
xref: UniProtKB:Q4V8I7
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000030752 ! volume-regulated anion channel subunit LRRC8A
relationship: has_gene_template RGD:1311690 ! Lrrc8a (rat)

[Term]
id: PR:Q8IWT6
name: volume-regulated anion channel subunit LRRC8A (human)
def: "A volume-regulated anion channel subunit LRRC8A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IWT6]
comment: Category=organism-gene.
synonym: "LRRC8" RELATED Gene-based [UniProtKB:Q8IWT6]
synonym: "LRRC8A" RELATED Gene-based [UniProtKB:Q8IWT6]
synonym: "SWELL1" RELATED Gene-based [UniProtKB:Q8IWT6]
synonym: "hLRRC8A" EXACT PRO-short-label [PRO:DNx]
synonym: "HsLRRC8A" EXACT [UniProtKB:Q8IWT6]
synonym: "KIAA1437" RELATED Gene-based [UniProtKB:Q8IWT6]
synonym: "UNQ221/PRO247" RELATED Gene-based [UniProtKB:Q8IWT6]
synonym: "swelling protein 1 (human)" EXACT [UniProtKB:Q8IWT6]
synonym: "leucine-rich repeat-containing protein 8A (human)" EXACT [PRO:DNx]
xref: UniProtKB:Q8IWT6
xref: Reactome:R-HSA-8941524 "PR:Q8IWT6 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030752 ! volume-regulated anion channel subunit LRRC8A
relationship: has_gene_template HGNC:19027 ! LRRC8A (human)

[Term]
id: PR:Q4V8I7-1
name: volume-regulated anion channel subunit LRRC8A isoform 1 (rat)
def: "A volume-regulated anion channel subunit LRRC8A isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rLRRC8A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q4V8I7-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000041715 ! volume-regulated anion channel subunit LRRC8A isoform 1

[Term]
id: PR:000057622
name: volume-regulated anion channel subunit LRRC8A O-glycosylated 1 (human)
def: "A volume-regulated anion channel subunit LRRC8A (human) that has been O-glycosylated at the residue equivalent to Thr-89 of the amino acid sequence represented by UniProtKB:Q8IWT6-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8IWT6-1, Thr-89, MOD:00005~GNO:G43417UB." [GlyGen:Q8IWT6-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hLRRC8A/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IWT6-1, Thr-89, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8IWT6 ! volume-regulated anion channel subunit LRRC8A (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens