[Term]
id: PR:Q4U2R1
name: E3 ubiquitin-protein ligase HERC2 (mouse)
def: "An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of mouse." [OMA:Q4U2R1, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rjs" RELATED Gene-based [UniProtKB:Q4U2R1]
synonym: "Jdf2" RELATED Gene-based [UniProtKB:Q4U2R1]
synonym: "Herc2" RELATED Gene-based [UniProtKB:Q4U2R1]
synonym: "mHERC2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa0393" RELATED Gene-based [UniProtKB:Q4U2R1]
synonym: "HECT-type E3 ubiquitin transferase HERC2 (mouse)" EXACT [UniProtKB:Q4U2R1]
synonym: "HECT domain and RCC1-like domain-containing protein 2 (mouse)" EXACT [UniProtKB:Q4U2R1]
xref: UniProtKB:Q4U2R1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000029541 ! E3 ubiquitin-protein ligase HERC2
relationship: has_gene_template MGI:103234 ! Herc2 (mouse)

[Term]
id: PR:Q9VR91
name: probable E3 ubiquitin-protein ligase HERC2 (fruit fly)
def: "An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of fruit fly." [OMA:Q9VR91, PRO:DNx]
comment: Category=organism-gene.
synonym: "HERC2" RELATED Gene-based [UniProtKB:Q9VR91]
synonym: "CG11734" RELATED Gene-based [UniProtKB:Q9VR91]
synonym: "fly-HERC2" EXACT PRO-short-label [PRO:DNx]
synonym: "HECT-type E3 ubiquitin transferase HERC2 (fruit fly)" EXACT [UniProtKB:Q9VR91]
synonym: "HECT domain and RCC1-like domain-containing protein 2 (fruit fly)" EXACT [UniProtKB:Q9VR91]
xref: UniProtKB:Q9VR91
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000029541 ! E3 ubiquitin-protein ligase HERC2
relationship: has_gene_template FlyBase:FBgn0031107 ! HERC2 (fruit fly)

[Term]
id: PR:000050928
name: E3 ubiquitin-protein ligase HERC2 N-glycosylated 1 (human)
def: "An E3 ubiquitin-protein ligase HERC2 (human) that has been N-glycosylated at the residue equivalent to Asn-2790 of the amino acid sequence represented by UniProtKB:O95714-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:O95714-1, Asn-2790, MOD:00160~GNO:G59626AS." [GlyGen:O95714-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHERC2/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O95714-1, Asn-2790, MOD:00160~GNO:G59626AS" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O95714 ! E3 ubiquitin-protein ligase HERC2 (human)
relationship: has_part GNO:G59626AS ! G59626AS
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000029541
name: E3 ubiquitin-protein ligase HERC2
def: "A protein that is a translation product of the human HERC2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HERC2" EXACT PRO-short-label [PRO:DNx]
synonym: "HECT-type E3 ubiquitin transferase HERC2" EXACT []
synonym: "HECT domain and RCC1-like domain-containing protein 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9VR91-2
name: probable E3 ubiquitin-protein ligase HERC2 isoform A (fruit fly)
def: "A probable E3 ubiquitin-protein ligase HERC2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VR91-2." [PRO:DNx, UniProtKB:Q9VR91]
comment: Category=organism-sequence.
synonym: "fly-HERC2/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VR91-2
is_a: PR:Q9VR91 ! probable E3 ubiquitin-protein ligase HERC2 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000045620
name: E3 ubiquitin-protein ligase HERC2 phosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase HERC2 (human) that has been phosphorylated at Thr-4827. UniProtKB:O95714, Thr-4827, MOD:00047." [PMID:20023648, iPTMnet:O95714]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20023648). Status=unreviewed.
synonym: "hHERC2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O95714, Thr-4827, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5682601 "PR:000045620 located_in GO:0005654"
is_a: PR:O95714 ! E3 ubiquitin-protein ligase HERC2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q4U2R1-1
name: E3 ubiquitin-protein ligase HERC2 isoform m1 (mouse)
def: "An E3 ubiquitin-protein ligase HERC2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q4U2R1-1." [PRO:DNx, UniProtKB:Q4U2R1]
comment: Category=organism-sequence.
synonym: "mHERC2/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q4U2R1-1
is_a: PR:Q4U2R1 ! E3 ubiquitin-protein ligase HERC2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q4U2R1-2
name: E3 ubiquitin-protein ligase HERC2 isoform m2 (mouse)
def: "An E3 ubiquitin-protein ligase HERC2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q4U2R1-2." [PRO:DNx, UniProtKB:Q4U2R1]
comment: Category=organism-sequence.
synonym: "mHERC2/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q4U2R1-2
is_a: PR:Q4U2R1 ! E3 ubiquitin-protein ligase HERC2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O95714
name: E3 ubiquitin-protein ligase HERC2 (human)
def: "An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O95714]
comment: Category=organism-gene.
synonym: "HERC2" RELATED Gene-based [UniProtKB:O95714]
synonym: "hHERC2" EXACT PRO-short-label [PRO:DNx]
synonym: "HECT-type E3 ubiquitin transferase HERC2 (human)" EXACT [UniProtKB:O95714]
synonym: "HECT domain and RCC1-like domain-containing protein 2 (human)" EXACT [UniProtKB:O95714]
xref: Reactome:R-HSA-975975 "PR:O95714 located_in GO:0005829"
xref: Reactome:R-HSA-4551680 "PR:O95714 located_in GO:0005654"
xref: UniProtKB:O95714
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029541 ! E3 ubiquitin-protein ligase HERC2
relationship: has_gene_template HGNC:4868 ! HERC2 (human)

[Term]
id: PR:Q9VR91-1
name: probable E3 ubiquitin-protein ligase HERC2 isoform B (fruit fly)
def: "A probable E3 ubiquitin-protein ligase HERC2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VR91-1." [PRO:DNx, UniProtKB:Q9VR91]
comment: Category=organism-sequence.
synonym: "fly-HERC2/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VR91-1
is_a: PR:Q9VR91 ! probable E3 ubiquitin-protein ligase HERC2 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster