[Term]
id: PR:000028679
name: traf6:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), TICAM2, TICAM1 and TRAF6." [Reactome:R-HSA-936976]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:TRAF6" RELATED [Reactome:R-HSA-936976]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000028705
name: pUbtraf6:ticam1:ticam2:activated TLR4 complex
def: "A traf6:ticam1:ticam2:activated TLR4 complex in which TRAF6 is polyubiquitinated. Ubiquitin is attached to TRAF6 through an isopeptide bond between the C-terminus of ubiquitin and the epsilon-amino group of a Lys residue in the target protein." [Reactome:R-HSA-936965]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:K63-pUb-TRAF6" RELATED [Reactome:R-HSA-936965]
is_a: PR:000028679 ! traf6:ticam1:ticam2:activated TLR4 complex

[Term]
id: PR:000028680
name: traf6:ticam1:ticam2:activated TLR4 complex (human)
def: "A traf6:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:R-HSA-936976]
comment: Category=organism-complex.
synonym: "activated TLR4:TRAM:TRIF:TRAF6 (human)" EXACT [Reactome:R-HSA-936976]
synonym: "traf6:trif:tram:activated TLR4 complex (human)" EXACT []
is_a: PR:000028679 ! traf6:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035702 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: has_component PR:Q9Y4K3 {cardinality="1"} ! TNF receptor-associated factor 6 (human)

[Term]
id: PR:000035715
name: pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
def: "A pUbtraf6:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PRO:DAN, Reactome:R-HSA-936965]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-pUb-TRAF6 (human)" RELATED [Reactome:R-HSA-936965]
is_a: PR:000028705 ! pUbtraf6:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035714 {cardinality="2"} ! TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000035710
name: traf6:ticam1:ticam2:activated TLR4 complex (mouse)
def: "A traf6:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of mouse." [TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "traf6:trif:tram:activated TLR4 complex (mouse)" EXACT []
is_a: PR:000028679 ! traf6:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:P70196 ! TNF receptor-associated factor 6 (mouse)
relationship: has_component PR:Q80UF7 ! TIR domain-containing adapter molecule 1 (mouse)
relationship: has_component PR:Q8BJQ4 ! TIR domain-containing adapter molecule 2 (mouse)