[Term]
id: PR:P12931
name: proto-oncogene tyrosine-protein kinase Src (human)
def: "A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12931]
comment: Category=organism-gene.
synonym: "SRC" RELATED Gene-based [UniProtKB:P12931]
synonym: "SRC1" RELATED Gene-based [UniProtKB:P12931]
synonym: "hSRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p60-Src (human)" EXACT [UniProtKB:P12931]
synonym: "pp60c-src (human)" EXACT [UniProtKB:P12931]
synonym: "proto-oncogene c-Src (human)" EXACT [UniProtKB:P12931]
xref: Reactome:R-HSA-9628701 "PR:P12931 located_in GO:0005829"
xref: DTO:03100484
xref: UniProtKB:P12931
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src
relationship: has_gene_template HGNC:11283 ! SRC (human)

[Term]
id: PR:Q9WUD9-2
name: proto-oncogene tyrosine-protein kinase Src isoform r2 (rat)
def: "A proto-oncogene tyrosine-protein kinase Src (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WUD9-2." [PRO:DNx, UniProtKB:Q9WUD9]
comment: Category=organism-sequence.
synonym: "rSRC/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene tyrosine-protein kinase Src isoform Neuronal Src (rat)" EXACT [UniProtKB:Q9WUD9]
xref: UniProtKB:Q9WUD9-2
is_a: PR:Q9WUD9 ! proto-oncogene tyrosine-protein kinase Src (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q9WUD9-1
name: proto-oncogene tyrosine-protein kinase Src isoform 1 (rat)
def: "A proto-oncogene tyrosine-protein kinase Src (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WUD9-1." [PRO:DNx, UniProtKB:Q9WUD9]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "rSRC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9WUD9-1
is_a: PR:Q9WUD9 ! proto-oncogene tyrosine-protein kinase Src (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P00523
name: proto-oncogene tyrosine-protein kinase Src (chicken)
def: "A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of chicken." [OMA:P00523, PRO:DNx]
comment: Category=organism-gene.
synonym: "SRC" RELATED Gene-based [UniProtKB:P00523]
synonym: "chick-SRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p60-Src (chicken)" EXACT [UniProtKB:P00523]
synonym: "pp60c-src (chicken)" EXACT [UniProtKB:P00523]
synonym: "proto-oncogene c-Src (chicken)" EXACT [UniProtKB:P00523]
xref: UniProtKB:P00523
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src
relationship: has_gene_template CGNC:49807 ! SRC (chicken)

[Term]
id: PR:P05480-2
name: neuronal proto-oncogene tyrosine-protein kinase Src isoform m2 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05480-2." [PRO:DNx, UniProtKB:P05480]
comment: Category=organism-sequence.
synonym: "mSRC/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05480-2
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P05480-1
name: neuronal proto-oncogene tyrosine-protein kinase Src isoform 1 (mouse)
def: "A proto-oncogene tyrosine-protein kinase Src isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSRC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05480-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027239 ! proto-oncogene tyrosine-protein kinase Src isoform 2

[Term]
id: PR:Q1JPZ3
name: proto-oncogene tyrosine-protein kinase Src (zebrafish)
def: "A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of zebrafish." [OMA:Q1JPZ3, PRO:DNx]
comment: Category=organism-gene.
synonym: "src" RELATED Gene-based [UniProtKB:Q1JPZ3]
synonym: "z-SRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p60-Src (zebrafish)" EXACT [UniProtKB:Q1JPZ3]
synonym: "pp60c-src (zebrafish)" EXACT [UniProtKB:Q1JPZ3]
synonym: "proto-oncogene c-Src (zebrafish)" EXACT [UniProtKB:Q1JPZ3]
xref: UniProtKB:Q1JPZ3
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src
relationship: has_gene_template ZFIN:ZDB-GENE-030131-3809 ! src (zebrafish)

[Term]
id: PR:P00523-1
name: proto-oncogene tyrosine-protein kinase Src isoform 1 (chicken)
def: "A proto-oncogene tyrosine-protein kinase Src (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00523-1." [PRO:DNx, UniProtKB:P00523]
comment: Category=organism-sequence.
synonym: "chick-SRC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00523-1
is_a: PR:P00523 ! proto-oncogene tyrosine-protein kinase Src (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:000037502
name: neuronal proto-oncogene tyrosine-protein kinase Src phosphorylated 3 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that has been phosphorylated on two residues at positions corresponding to Tyr-424 and Tyr-527 in UniProtKB:P05480. UniProtKB:P05480, Tyr-424/Tyr-527, MOD:00048." [PMID:23526378, PMID:2480346, PRO:HJD]
comment: Category=organism-modification. Kinase=("CSK"; PR:P41241; Tyr-527). Kinase=("SRC"; PR:P05480; Tyr-424). Note: Tyr-416 Src residue number in cited article is based on the chicken Src protein. This corresponds to Tyr-424 in mouse.
synonym: "mSRC/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "pp60c-src phosphorylated (mouse)" RELATED []
synonym: "UniProtKB:P05480, Tyr-424/Tyr-527, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037501
name: neuronal proto-oncogene tyrosine-protein kinase Src phosphorylated 2 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that has been phosphorylated on a Tyr residue as in UniProtKB:P05480, Tyr-424, MOD:00048. UniProtKB:P05480, Tyr-424, MOD:00048." [PMID:23526378, PMID:2480346, PRO:HJD]
comment: Category=organism-modification. Note: Tyr-416 Src residue number in cited article is based on the chicken Src protein. This corresponds to Tyr-424 in mouse.
synonym: "mSRC/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "pp60c-src phosphorylated (mouse)" RELATED []
synonym: "UniProtKB:P05480, Tyr-424, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037500
name: neuronal proto-oncogene tyrosine-protein kinase Src phosphorylated 1 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that has been phosphorylated on a Tyr residue as in UniProtKB:P05480, Tyr-527, MOD:00048. UniProtKB:P05480, Tyr-527, MOD:00048." [PMID:23526378, PMID:2480346, PRO:HJD]
comment: Category=organism-modification. Kinase=("CSK"; PR:P41241).
synonym: "mSRC/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "pp60c-src phosphorylated (mouse)" RELATED []
synonym: "UniProtKB:P05480, Tyr-527, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000027238
name: proto-oncogene tyrosine-protein kinase Src isoform 1 phosphorylated 1 (human)
def: "A proto-oncogene tyrosine-protein kinase Src isoform 1 phosphorylated 1 in human. UniProtKB:P12931-1, Tyr-419, MOD:00048." [PMID:8789131, PRO:PD]
comment: Category=organism-modification. Note that the Src residue number in cited article is based on the chicken Src protein.
synonym: "hSRC/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P12931-1, Tyr-419, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-377592 "PR:000027238 located_in GO:0005829"
xref: Reactome:R-HSA-112331 "PR:000027238 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027237 ! proto-oncogene tyrosine-protein kinase Src isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000049780
name: neuronal proto-oncogene tyrosine-protein kinase Src unphosphorylated 2 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that lacks phosphorylation at the position equivalent to Tyr-424 of the amino acid sequence represented by UniProtKB:P05480. UniProtKB:P05480, Tyr-424, PR:000026291." [PMID:26764350, PRO:HJD]
comment: Category=organism-modification.
synonym: "mSRC/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05480, Tyr-424, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049781
name: neuronal proto-oncogene tyrosine-protein kinase Src unphosphorylated 1 (mouse)
def: "A neuronal proto-oncogene tyrosine-protein kinase Src (mouse) that is unphosphorylated at the position equivalent to Tyr-527 of the amino acid sequence represented by UniProtKB:P05480. UniProtKB:P05480, Tyr-527, PR:000026291." [PMID:26764350, PRO:HJD]
comment: Category=organism-modification.
synonym: "mSRC/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05480, Tyr-527, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05480 ! neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P05480
name: neuronal proto-oncogene tyrosine-protein kinase Src (mouse)
def: "A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of mouse." [OMA:P05480, PRO:DNx]
comment: Category=organism-gene.
synonym: "Src" RELATED Gene-based [UniProtKB:P05480]
synonym: "mSRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p60-Src (mouse)" EXACT [UniProtKB:P05480]
synonym: "pp60c-src (mouse)" EXACT [UniProtKB:P05480]
synonym: "proto-oncogene c-Src (mouse)" EXACT [UniProtKB:P05480]
xref: UniProtKB:P05480
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src
relationship: has_gene_template MGI:98397 ! Src (mouse)

[Term]
id: PR:000027234
name: proto-oncogene tyrosine-protein kinase Src
def: "A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human SRC gene or a 1:1 ortholog thereof." [PMID:18789131, PRO:CNA]
comment: Category=gene.
synonym: "SRC" EXACT PRO-short-label [PRO:DNx]
synonym: "SRC1" RELATED Gene-based []
synonym: "p60-Src" EXACT []
synonym: "pp60c-src" EXACT []
synonym: "Proto-oncogene c-Src" EXACT []
xref: IUPHARobj:2206
is_a: PR:000002997 ! proto-oncogene SRC-like tyrosine-protein kinase

[Term]
id: PR:000027235
name: proto-oncogene tyrosine-protein kinase Src isoform 1
def: "A proto-oncogene tyrosine-protein kinase Src that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12931-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "SRC/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src

[Term]
id: PR:P00523-2
name: proto-oncogene tyrosine-protein kinase Src isoform 2 (chicken)
def: "A proto-oncogene tyrosine-protein kinase Src (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00523-2." [PRO:DNx, UniProtKB:P00523]
comment: Category=organism-sequence.
synonym: "chick-SRC/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00523-2
is_a: PR:P00523 ! proto-oncogene tyrosine-protein kinase Src (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:000027237
name: proto-oncogene tyrosine-protein kinase Src isoform 1 phosphorylated 1
def: "A proto-oncogene tyrosine-protein kinase Src isoform 1 that has been post-translationally modified to include a phosphotyrosine following irradiation. Example: UniProtKB:P12931-1, Tyr-419, MOD:00048." [PRO:CNA]
comment: Category=modification.
synonym: "SRC/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027235 ! proto-oncogene tyrosine-protein kinase Src isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P12931-2
name: proto-oncogene tyrosine-protein kinase Src isoform 2 (human)
def: "A proto-oncogene tyrosine-protein kinase Src isoform 2 that is encoded in the genome of human." [PMID:1691439, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSRC/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12931-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027239 ! proto-oncogene tyrosine-protein kinase Src isoform 2

[Term]
id: PR:000027239
name: proto-oncogene tyrosine-protein kinase Src isoform 2
def: "A proto-oncogene tyrosine-protein kinase Src that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12931-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "SRC/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src

[Term]
id: PR:P12931-1
name: proto-oncogene tyrosine-protein kinase Src isoform 1 (human)
def: "A proto-oncogene tyrosine-protein kinase Src isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSRC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12931-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027235 ! proto-oncogene tyrosine-protein kinase Src isoform 1

[Term]
id: PR:000045674
name: proto-oncogene tyrosine-protein kinase Src phosphorylated 1 (human)
def: "A proto-oncogene tyrosine-protein kinase Src (human) that has been phosphorylated at the position equivalent to Ser-75 of the amino acid sequence represented by UniProtKB:P12931-1. Example: UniProtKB:P12931-1, Ser-75, MOD:00046." [PMID:10544291, iPTMnet:P12931]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10544291). Status=unreviewed.
synonym: "hSRC/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P12931-1, Ser-75, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P12931 ! proto-oncogene tyrosine-protein kinase Src (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9WUD9
name: proto-oncogene tyrosine-protein kinase Src (rat)
def: "A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of rat." [OMA:Q9WUD9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Src" RELATED Gene-based [UniProtKB:Q9WUD9]
synonym: "rSRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p60-Src (rat)" EXACT [UniProtKB:Q9WUD9]
synonym: "pp60c-src (rat)" EXACT [UniProtKB:Q9WUD9]
synonym: "proto-oncogene c-Src (rat)" EXACT [UniProtKB:Q9WUD9]
xref: UniProtKB:Q9WUD9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000027234 ! proto-oncogene tyrosine-protein kinase Src
relationship: has_gene_template RGD:620795 ! Src (rat)