[Term]
id: PR:000027102
name: TAK1 kinase complex (mouse)
def: "A TAK1 kinase complex whose components are encoded in the genome of mouse." [PMID:16410796, PMID:18021073, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TAK1TAB1TAB2TAB3" RELATED [TLR:AMM]
synonym: "mouse TAK1-TAB1-TAB2-TAB3" RELATED []
is_a: PR:000027077 ! TAK1 kinase complex
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027101 ! mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (mouse)
relationship: has_component PR:Q62073 ! mitogen-activated protein kinase kinase kinase 7 (mouse)
relationship: has_component PR:Q8CF89 ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse)

[Term]
id: PR:000027078
name: TRIKA2 complex
def: "A TAK1 kinase complex that is composed of TAK1, TAB1 and TAB2." [PMID:11460167, TLR:AMM]
comment: Category=complex. Requested by=TLR.
synonym: "TAK1-TAB1-TAB2" RELATED []
is_a: PR:000027077 ! TAK1 kinase complex

[Term]
id: PR:000027077
name: TAK1 kinase complex
def: "A protein-containing complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunit)." [PMID:16410796, PMID:17496917, PMID:18021073, PRO:CNA]
comment: Category=complex. Requested GO term.
synonym: "TAK1-TAB1-TAB2-TAB3" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000035730
name: TAK1 kinase complex (human)
def: "A TAK1 kinase complex whose components are encoded in the genome of human." [Reactome:R-HSA-450277]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TAB1:TAB2,TAB3:TAK1 (human)" EXACT [Reactome:R-HSA-450277]
xref: Reactome:R-HSA-450277 "PR:000035730 located_in GO:0005829"
is_a: PR:000027077 ! TAK1 kinase complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000027103 {cardinality="1"} ! mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human)
relationship: has_component PR:O43318 {cardinality="1"} ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: has_component PR:Q15750 {cardinality="1"} ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)

[Term]
id: PR:000027105
name: TRIKA2 complex (mouse)
def: "A TRIKA2 complex whose components are encoded in the genome of mouse." [PMID:11460167, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "mouse TRIKA2" EXACT []
synonym: "mouse TAK1-TAB1-TAB2" RELATED []
is_a: PR:000027078 ! TRIKA2 complex
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:Q62073 ! mitogen-activated protein kinase kinase kinase 7 (mouse)
relationship: has_component PR:Q8CF89 ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse)
relationship: has_component PR:Q99K90 ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse)