[Term] id: PR:000037507 name: transcriptional coactivator YAP1 isoform 3 unphosphorylated 1 (human) def: "A transcriptional coactivator YAP1 isoform 3 (human) that lacks a phosphorylated Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER] comment: Category=organism-modification. synonym: "hYAP1/iso:3/UnPhos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P46937-3, Tyr-357, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P46937-3 ! transcriptional coactivator YAP1 isoform 3 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-8 name: transcriptional coactivator YAP1 isoform h8 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-8." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h8" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-2beta (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-8 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037510 name: transcriptional coactivator YAP1 phosphorylated 1 (human) def: "A transcriptional coactivator YAP1 (human) that has been phosphorylated on a residue equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, MOD:00046." [PMID:20153295, PMID:21214929, PMID:21945154, PRO:KER] comment: Category=organism-modification. Kinase=("AKT"; PR:000029189; Ser-127). Kinase=("PKC"; PR:000003057; Ser-127). Note: Isoform PR:P46937-4 is excluded from this class as it lacks the region containing the corresponding Ser (isoform 4 lacks the N-terminal region of 178 residues compared to isoform 1). synonym: "hYAP1/Phos:1" EXACT PRO-short-label [PRO:DAN] synonym: "hYap1 Ser127" EXACT [] synonym: "UniProtKB:P46937-1, Ser-127, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2028553 "PR:000037510 located_in GO:0005829" is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-1 name: transcriptional coactivator YAP1 isoform h1 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-1." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h1" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP2L (human)" EXACT [UniProtKB:P46937] synonym: "transcriptional coactivator YAP1 isoform YAP1-2gamma (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-1 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-3 name: transcriptional coactivator YAP1 isoform 3 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-3." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:3" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-1beta (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-3 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-2 name: transcriptional coactivator YAP1 isoform h2 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-2." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP2 (human)" EXACT [UniProtKB:P46937] synonym: "transcriptional coactivator YAP1 isoform YAP1-2alpha (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-2 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-5 name: transcriptional coactivator YAP1 isoform h5 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-5." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h5" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-1alpha (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-5 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-4 name: transcriptional coactivator YAP1 isoform h4 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-4." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P46937-4 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037509 name: transcriptional coactivator YAP1 unphosphorylated 1 (human) def: "A transcriptional coactivator YAP1 (human) that lacks phosphorylation at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER] comment: Category=organism-modification. Note: Isoform PR:P46937-4 is excluded from this class as it lacks the region containing the corresponding Ser (isoform 4 lacks the N-terminal region of 178 residues compared to isoform 1). synonym: "hYAP1/UnPhos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P46937-1, Ser-127, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037508 name: transcriptional coactivator YAP1 isoform 3 phosphorylated 1 (human) def: "A transcriptional coactivator YAP1 isoform 3 (human) that has been phosphorylated on a Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, MOD:00048." [PMID:21214929, PMID:21945154, PRO:KER] comment: Category=organism-modification. Kinase=("ABL1"; PR:P00519; Tyr-357). synonym: "hYAP1/iso:3/Phos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P46937-3, Tyr-357, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P46937-3 ! transcriptional coactivator YAP1 isoform 3 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937 name: transcriptional coactivator YAP1 (human) def: "A transcriptional coactivator YAP1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-gene. synonym: "YAP1" RELATED Gene-based [UniProtKB:P46937] synonym: "YAP65" RELATED Gene-based [UniProtKB:P46937] synonym: "hYAP1" EXACT PRO-short-label [PRO:DNx] synonym: "protein yorkie homolog (human)" EXACT [UniProtKB:P46937] synonym: "Yes-associated protein 1 (human)" EXACT [UniProtKB:P46937] synonym: "Yes-associated protein YAP65 homolog (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937 xref: Reactome:R-HSA-1253322 "PR:P46937 located_in GO:0005654" xref: Reactome:R-HSA-1253345 "PR:P46937 located_in GO:0005829" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000017522 ! transcriptional coactivator YAP1 relationship: has_gene_template HGNC:16262 ! YAP1 (human) [Term] id: PR:000017522 name: transcriptional coactivator YAP1 def: "A protein that is a translation product of the human YAP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Yap" RELATED Gene-based [] synonym: "YAP1" EXACT PRO-short-label [PRO:DNx] synonym: "YAP65" RELATED Gene-based [] synonym: "yorkie homolog" EXACT [] synonym: "protein yorkie homolog" EXACT [] synonym: "Yes-associated protein 1" EXACT [] synonym: "65 kDa Yes-associated protein" EXACT [] synonym: "Yes-associated protein YAP65 homolog" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:P46937-7 name: transcriptional coactivator YAP1 isoform h7 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-7." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h7" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-1delta (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-7 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049715 name: transcriptional coactivator YAP1 phosphorylated 3 (human) def: "A transcriptional coactivator YAP1 (human) that has been post-translationally modified to include phosphoserine at positions 61, 109, 127, 164 and 397 of the amino acid sequence represented by UniProtKB:P46937. UniProtKB:P46937, Ser-61/Ser-109/Ser-127/Ser-164/Ser-397, MOD:00046." [PRO:DNx, Reactome:R-HSA-2028554] comment: Category=organism-modification. synonym: "hYAP1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P46937, Ser-61/Ser-109/Ser-127/Ser-164/Ser-397, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2028554 "PR:000049715 located_in GO:0005829" is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-9 name: transcriptional coactivator YAP1 isoform h9 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-9." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h9" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-2delta (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-9 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P46937-6 name: transcriptional coactivator YAP1 isoform h6 (human) def: "A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-6." [PRO:DNx, UniProtKB:P46937] comment: Category=organism-sequence. synonym: "hYAP1/iso:h6" EXACT PRO-short-label [PRO:DNx] synonym: "transcriptional coactivator YAP1 isoform YAP1-1gamma (human)" EXACT [UniProtKB:P46937] xref: UniProtKB:P46937-6 is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045791 name: transcriptional coactivator YAP1 phosphorylated 2 (human) def: "A transcriptional coactivator YAP1 (human) that has been phosphorylated at the position equivalent to Ser-94 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-94, MOD:00046." [PMID:25751140, iPTMnet:P46937] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25751140). Status=unreviewed. synonym: "hYAP1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P46937-1, Ser-94, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P46937 ! transcriptional coactivator YAP1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens