[Term] id: PR:000017509 name: X-ray repair cross-complementing protein 6 def: "A protein that is a translation product of the human XRCC6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Ku70" RELATED Gene-based [] synonym: "TLAA" RELATED [] synonym: "CTC75" EXACT [] synonym: "CTCBF" RELATED [] synonym: "G22P1" RELATED Gene-based [] synonym: "XRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "DNA repair protein XRCC6" EXACT [] synonym: "thyroid-lupus autoantigen" RELATED [] synonym: "70 kDa subunit of Ku antigen" EXACT [] synonym: "lupus Ku autoantigen protein p70" EXACT [] synonym: "Ku autoantigen protein p70 homolog" EXACT [] synonym: "5'-deoxyribose-5-phosphate lyase Ku70" EXACT [] synonym: "CTC box-binding factor 75 kDa subunit" EXACT [] synonym: "ATP-dependent DNA helicase 2 subunit 1" EXACT [] synonym: "ATP-dependent DNA helicase II 70 kDa subunit" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:Q9FQ08 name: ATP-dependent DNA helicase 2 subunit KU70 (Arabidopsis thaliana) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9FQ08, PANTHER:PTHR12604:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "KU70" RELATED Gene-based [UniProtKB:Q9FQ08] synonym: "F6I1.2" RELATED Gene-based [UniProtKB:Q9FQ08] synonym: "At-XRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "At1g16970" RELATED Gene-based [UniProtKB:Q9FQ08] synonym: "ATP-dependent DNA helicase 2 subunit 1 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9FQ08] synonym: "ATP-dependent DNA helicase II 70 kDa subunit (Arabidopsis thaliana)" EXACT [UniProtKB:Q9FQ08] xref: UniProtKB:Q9FQ08 intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template Araport:AT1G16970 ! KU70 (Arabidopsis thaliana) [Term] id: PR:P12956-2 name: X-ray repair cross-complementing protein 6 isoform h2 (human) def: "An X-ray repair cross-complementing protein 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12956-2." [PRO:DNx, UniProtKB:P12956] comment: Category=organism-sequence. synonym: "hXRCC6/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P12956-2 is_a: PR:P12956 ! X-ray repair cross-complementing protein 6 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P12956-1 name: X-ray repair cross-complementing protein 6 isoform h1 (human) def: "An X-ray repair cross-complementing protein 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12956-1." [PRO:DNx, UniProtKB:P12956] comment: Category=organism-sequence. synonym: "hXRCC6/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P12956-1 is_a: PR:P12956 ! X-ray repair cross-complementing protein 6 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q23976 name: ATP-dependent DNA helicase 2 subunit 1 (fruit fly) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of fruit fly." [OMA:Q23976, PANTHER:PTHR12604:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "Irbp" RELATED Gene-based [UniProtKB:Q23976] synonym: "dp70" RELATED Gene-based [UniProtKB:Q23976] synonym: "YPF1b" RELATED Gene-based [UniProtKB:Q23976] synonym: "CG5247" RELATED Gene-based [UniProtKB:Q23976] synonym: "fly-XRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "ATP-dependent helicase Irbp (fruit fly)" EXACT [UniProtKB:Q23976] synonym: "inverted repeat-binding protein (fruit fly)" EXACT [UniProtKB:Q23976] synonym: "yolk protein factor 1 subunit beta (fruit fly)" EXACT [UniProtKB:Q23976] synonym: "ATP-dependent DNA helicase II subunit dp70 (fruit fly)" EXACT [UniProtKB:Q23976] xref: UniProtKB:Q23976 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template FlyBase:FBgn0011774 ! Irbp (fruit fly) [Term] id: PR:O94395 name: ATP-dependent DNA helicase II subunit 1 (Schizosaccharomyces pombe 972h-) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O94395, PANTHER:PTHR12604:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "ku70" RELATED Gene-based [UniProtKB:O94395] synonym: "pku70" RELATED Gene-based [UniProtKB:O94395] synonym: "SPCC126.02c" RELATED Gene-based [UniProtKB:O94395] synonym: "Spom972h-XRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "ATP-dependent DNA helicase II subunit Ku70 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O94395] xref: UniProtKB:O94395 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template PomBase:SPCC126.02c ! pku70 (Schizosaccharomyces pombe) [Term] id: PR:000021864 name: X-ray repair cross-complementing protein 6, initiator methionine removed form def: "An X-ray repair cross-complementing protein 6 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "XRCC6/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:P23475 name: X-ray repair cross-complementing protein 6 (mouse) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of mouse." [OMA:P23475, PRO:DNx] comment: Category=organism-gene. synonym: "Ku70" RELATED Gene-based [UniProtKB:P23475] synonym: "G22p1" RELATED Gene-based [UniProtKB:P23475] synonym: "Xrcc6" RELATED Gene-based [UniProtKB:P23475] synonym: "mXRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "CTC75 (mouse)" EXACT [UniProtKB:P23475] synonym: "CTCBF (mouse)" RELATED [UniProtKB:P23475] synonym: "5'-dRP/AP lyase Ku70 (mouse)" EXACT [UniProtKB:P23475] synonym: "DNA repair protein XRCC6 (mouse)" EXACT [UniProtKB:P23475] synonym: "Ku autoantigen protein p70 homolog (mouse)" EXACT [UniProtKB:P23475] synonym: "5'-deoxyribose-5-phosphate lyase Ku70 (mouse)" EXACT [UniProtKB:P23475] synonym: "CTC box-binding factor 75 kDa subunit (mouse)" EXACT [UniProtKB:P23475] synonym: "ATP-dependent DNA helicase 2 subunit 1 (mouse)" EXACT [UniProtKB:P23475] synonym: "ATP-dependent DNA helicase II 70 kDa subunit (mouse)" EXACT [UniProtKB:P23475] xref: UniProtKB:P23475 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template MGI:95606 ! Xrcc6 (mouse) [Term] id: PR:P32807 name: ATP-dependent DNA helicase II subunit 1 (yeast) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of yeast." [OMA:P32807, PANTHER:PTHR12604:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "HDF1" RELATED Gene-based [UniProtKB:P32807] synonym: "NES24" RELATED Gene-based [UniProtKB:P32807] synonym: "YKU70" RELATED Gene-based [UniProtKB:P32807] synonym: "yXRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "YMR284W" RELATED Gene-based [UniProtKB:P32807] synonym: "YM8021.10" RELATED Gene-based [UniProtKB:P32807] synonym: "ATP-dependent DNA helicase II subunit Ku70 (yeast)" EXACT [UniProtKB:P32807] synonym: "high affinity DNA-binding factor subunit 1 (yeast)" EXACT [UniProtKB:P32807] xref: UniProtKB:P32807 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template SGD:S000004897 ! YKU70 (yeast) [Term] id: PR:000049714 name: X-ray repair cross-complementing protein 6, initiator methionine removed form (human) def: "An X-ray repair cross-complementing protein 6 (human) that has had the initiator methionine removed. UniProtKB:P12956, 2-609." [PRO:DNx, Reactome:R-HSA-3134813, Reactome:R-HSA-58272] comment: Category=organism-modification. synonym: "PRO_0000210179" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hXRCC6/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P12956, 2-609" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-58272 "PR:000049714 located_in GO:0005654" xref: Reactome:R-HSA-3134813 "PR:000049714 located_in GO:0005829" xref: Reactome:R-HSA-6801300 "PR:000049714 located_in GO:1904813" xref: Reactome:R-HSA-6801312 "PR:000049714 located_in GO:0034774" xref: Reactome:R-HSA-6806444 "PR:000049714 located_in GO:0005576" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P12956 ! X-ray repair cross-complementing protein 6 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O93257 name: X-ray repair cross-complementing protein 5 (chicken) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of chicken." [OMA:O93257, PANTHER:PTHR12604:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "KU70" RELATED Gene-based [UniProtKB:O93257] synonym: "G22P1" RELATED Gene-based [UniProtKB:O93257] synonym: "XRCC6" RELATED Gene-based [UniProtKB:O93257] synonym: "chick-XRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "Ku70 (chicken)" EXACT [UniProtKB:O93257] synonym: "5'-dRP/AP lyase Ku70 (chicken)" EXACT [UniProtKB:O93257] synonym: "DNA repair protein XRCC6 (chicken)" EXACT [UniProtKB:O93257] synonym: "Ku autoantigen protein p70 homolog (chicken)" EXACT [UniProtKB:O93257] synonym: "5'-deoxyribose-5-phosphate lyase Ku70 (chicken)" EXACT [UniProtKB:O93257] synonym: "ATP-dependent DNA helicase 2 subunit 1 (chicken)" EXACT [UniProtKB:O93257] synonym: "ATP-dependent DNA helicase II 70 kDa subunit (chicken)" EXACT [UniProtKB:O93257] xref: UniProtKB:O93257 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template NCBIGene:395767 ! XRCC6 (chicken) [Term] id: PR:P12956 name: X-ray repair cross-complementing protein 6 (human) def: "An X-ray repair cross-complementing protein 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12956] comment: Category=organism-gene. synonym: "G22P1" RELATED Gene-based [UniProtKB:P12956] synonym: "XRCC6" RELATED Gene-based [UniProtKB:P12956] synonym: "hXRCC6" EXACT PRO-short-label [PRO:DNx] synonym: "Ku70 (human)" EXACT [UniProtKB:P12956] synonym: "TLAA (human)" BROAD [UniProtKB:P12956] synonym: "CTC75 (human)" EXACT [UniProtKB:P12956] synonym: "CTCBF (human)" BROAD [UniProtKB:P12956] synonym: "5'-dRP lyase Ku70 (human)" EXACT [UniProtKB:P12956] synonym: "DNA repair protein XRCC6 (human)" EXACT [UniProtKB:P12956] synonym: "thyroid-lupus autoantigen (human)" BROAD [UniProtKB:P12956] synonym: "70 kDa subunit of Ku antigen (human)" EXACT [UniProtKB:P12956] synonym: "lupus Ku autoantigen protein p70 (human)" EXACT [UniProtKB:P12956] synonym: "5'-deoxyribose-5-phosphate lyase Ku70 (human)" EXACT [UniProtKB:P12956] synonym: "CTC box-binding factor 75 kDa subunit (human)" EXACT [UniProtKB:P12956] synonym: "ATP-dependent DNA helicase 2 subunit 1 (human)" EXACT [UniProtKB:P12956] synonym: "ATP-dependent DNA helicase II 70 kDa subunit (human)" EXACT [UniProtKB:P12956] synonym: "X-ray repair complementing defective repair in Chinese hamster cells 6 (human)" EXACT [UniProtKB:P12956] xref: UniProtKB:P12956 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000017509 ! X-ray repair cross-complementing protein 6 relationship: has_gene_template HGNC:4055 ! XRCC6 (human)