[Term]
id: PR:P11388
name: DNA topoisomerase 2-alpha (human)
def: "A DNA topoisomerase 2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11388]
comment: Category=organism-gene.
synonym: "TOP2" RELATED Gene-based [UniProtKB:P11388]
synonym: "TOP2A" RELATED Gene-based [UniProtKB:P11388]
synonym: "hTOP2A" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, alpha isozyme (human)" EXACT [UniProtKB:P11388]
xref: Reactome:R-HSA-1362276 "PR:P11388 located_in GO:0005654"
xref: UniProtKB:P11388
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016544 ! DNA topoisomerase 2-alpha
relationship: has_gene_template HGNC:11989 ! TOP2A (human)

[Term]
id: PR:P11388-4
name: DNA topoisomerase 2-alpha isoform h4 (human)
def: "A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-4." [PRO:DNx, UniProtKB:P11388]
comment: Category=organism-sequence.
synonym: "hTOP2A/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11388-4
is_a: PR:P11388 ! DNA topoisomerase 2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000016544
name: DNA topoisomerase 2-alpha
def: "A protein that is a translation product of the human TOP2A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TOP2" RELATED Gene-based []
synonym: "TOP2A" EXACT PRO-short-label [PRO:DNx]
synonym: "Top-2" RELATED Gene-based []
synonym: "DNA topoisomerase II, alpha isozyme" EXACT []
xref: IUPHARobj:2637
is_a: PR:000000001 ! protein

[Term]
id: PR:P11388-1
name: DNA topoisomerase 2-alpha isoform h1 (human)
def: "A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-1." [PRO:DNx, UniProtKB:P11388]
comment: Category=organism-sequence.
synonym: "hTOP2A/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11388-1
is_a: PR:P11388 ! DNA topoisomerase 2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11388-3
name: DNA topoisomerase 2-alpha isoform h3 (human)
def: "A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-3." [PRO:DNx, UniProtKB:P11388]
comment: Category=organism-sequence.
synonym: "hTOP2A/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11388-3
is_a: PR:P11388 ! DNA topoisomerase 2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11388-2
name: DNA topoisomerase 2-alpha isoform h2 (human)
def: "A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-2." [PRO:DNx, UniProtKB:P11388]
comment: Category=organism-sequence.
synonym: "hTOP2A/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11388-2
is_a: PR:P11388 ! DNA topoisomerase 2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q01320
name: DNA topoisomerase 2-alpha (mouse)
def: "A DNA topoisomerase 2-alpha that is encoded in the genome of mouse." [OMA:Q01320, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top2" RELATED Gene-based [UniProtKB:Q01320]
synonym: "Top-2" RELATED Gene-based [UniProtKB:Q01320]
synonym: "Top2a" RELATED Gene-based [UniProtKB:Q01320]
synonym: "mTOP2A" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, alpha isozyme (mouse)" EXACT [UniProtKB:Q01320]
xref: UniProtKB:Q01320
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016544 ! DNA topoisomerase 2-alpha
relationship: has_gene_template MGI:98790 ! Top2a (mouse)

[Term]
id: PR:O42130
name: DNA topoisomerase 2-alpha (chicken)
def: "A DNA topoisomerase 2-alpha that is encoded in the genome of chicken." [OMA:O42130, PANTHER:PTHR10169:SF17, PRO:DNx]
comment: Category=organism-gene.
synonym: "TOP2A" RELATED Gene-based [UniProtKB:O42130]
synonym: "chick-TOP2A" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, alpha isozyme (chicken)" EXACT [UniProtKB:O42130]
xref: UniProtKB:O42130
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000016544 ! DNA topoisomerase 2-alpha
relationship: has_gene_template NCBIGene:395570 ! TOP2A (chicken)

[Term]
id: PR:P41516
name: DNA topoisomerase 2-alpha (rat)
def: "A DNA topoisomerase 2-alpha that is encoded in the genome of rat." [OMA:P41516, PANTHER:PTHR10169:SF17, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top2" RELATED Gene-based [UniProtKB:P41516]
synonym: "Top-2" RELATED Gene-based [UniProtKB:P41516]
synonym: "Top2a" RELATED Gene-based [UniProtKB:P41516]
synonym: "rTOP2A" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, alpha isozyme (rat)" EXACT [UniProtKB:P41516]
xref: UniProtKB:P41516
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016544 ! DNA topoisomerase 2-alpha
relationship: has_gene_template RGD:62048 ! Top2a (rat)