[Term]
id: PR:000049508
name: DNA topoisomerase 1, initiator methionine removed form (human)
def: "A DNA topoisomerase 1 (human) that has had the initiator methionine removed. UniProtKB:P11387, 2-765." [PRO:DNx, Reactome:R-HSA-4641363]
comment: Category=organism-modification.
synonym: "PRO_0000145201" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTOP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11387, 2-765" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641363 "PR:000049508 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P11387 ! DNA topoisomerase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049509
name: DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)
def: "A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]
comment: Category=organism-modification.
synonym: "hTOP1/InitMet-/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000145201, Lys-117, MOD:01149" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11387, 2-765, Lys-117, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641364 "PR:000049509 located_in GO:0005654"
is_a: PR:P11387 ! DNA topoisomerase 1 (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000016542
name: type 1B DNA topoisomerase 1
def: "A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "Top-1" RELATED Gene-based []
synonym: "DNA topoisomerase I" BROAD [PRO:DNx]
xref: IUPHARobj:2636
is_a: PR:000000001 ! protein

[Term]
id: PR:P11387
name: DNA topoisomerase 1 (human)
def: "A type 1B DNA topoisomerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11387]
comment: Category=organism-gene.
synonym: "TOP1" RELATED Gene-based [UniProtKB:P11387]
synonym: "hTOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase I (human)" EXACT [UniProtKB:P11387]
xref: UniProtKB:P11387
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
relationship: has_gene_template HGNC:11986 ! TOP1 (human)