[Term] id: PR:000036997 name: serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC] comment: Category=organism-modification. synonym: "mSTK11/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000036996 ! serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 [Term] id: PR:000015740 name: serine/threonine-protein kinase STK11 def: "A protein that is a translation product of the human STK11 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PJS" RELATED Gene-based [] synonym: "LKB1" RELATED Gene-based [] synonym: "STK11" EXACT PRO-short-label [PRO:DNx] synonym: "renal carcinoma antigen NY-REN-19" EXACT [] synonym: "serine/threonine-protein kinase LKB1" EXACT [] xref: IUPHARobj:2212 is_a: PR:000000001 ! protein [Term] id: PR:000036995 name: serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC] comment: Category=organism-modification. Kinase=("LCK"; PR:P06240). synonym: "mSTK11/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "LKB1(L) tyrosine phosphorylated" RELATED [] synonym: "UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000036994 ! serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000036893 name: serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC] comment: Category=organism-modification. Kinase=("FYN"; PR:P39688). synonym: "mSTK11/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "LKB1 tyrosine phosphorylated" RELATED [] synonym: "UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000036892 ! serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:Q9WTK7 name: serine/threonine-protein kinase STK11 (mouse) def: "A serine/threonine-protein kinase STK11 that is encoded in the genome of mouse." [OMA:Q9WTK7, PRO:DNx] comment: Category=organism-gene. synonym: "Lkb1" RELATED Gene-based [UniProtKB:Q9WTK7] synonym: "Stk11" RELATED Gene-based [UniProtKB:Q9WTK7] synonym: "mLKB1" EXACT [UniProtKB:Q9WTK7] synonym: "mSTK11" EXACT PRO-short-label [PRO:DNx] synonym: "LKB1 (mouse)" EXACT [UniProtKB:Q9WTK7] synonym: "liver kinase B1 homolog (mouse)" EXACT [UniProtKB:Q9WTK7] xref: UniProtKB:Q9WTK7 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000015740 ! serine/threonine-protein kinase STK11 relationship: has_gene_template MGI:1341870 ! Stk11 (mouse) [Term] id: PR:000045395 name: serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 (mouse) that is phosphorylated on Ser-431 and has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Ser-431, MOD:00046|Cys-433, MOD:00111." [PMID:24295069, PRO:KRC] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:24295069, for MOD:00111). Evidence=(ECO:0000006, based on PMID:24295069, for MOD:00046). Note: Neither farnesylation or phosphorylation is needed for kinase activity. synonym: "mSTK11/iso:1/FarnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "LKB1(L) farnesylated and phosphorylated" RELATED [] synonym: "UniProtKB:Q9WTK7-1, Ser-431, MOD:00046|Cys-433, MOD:00111" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9WTK7-1 ! serine/threonine-protein kinase STK11 isoform 1 (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00111 ! S-farnesyl-L-cysteine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000045394 name: serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 (mouse) that has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Cys-433, MOD:00111." [PMID:24295069, PRO:KRC] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:24295069, for MOD:00111). Note: Farnesylation is not needed for kinase activity. synonym: "mSTK11/iso:1/Farn:1" EXACT PRO-short-label [PRO:DNx] synonym: "LKB1(L) farnesylated" RELATED [] synonym: "UniProtKB:Q9WTK7-1, Cys-433, MOD:00111" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9WTK7-1 ! serine/threonine-protein kinase STK11 isoform 1 (mouse) relationship: has_part MOD:00111 ! S-farnesyl-L-cysteine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q9WTK7-1 name: serine/threonine-protein kinase STK11 isoform 1 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of mouse. This isoform includes the sequence encoded by exon IXa. This isoform is widely expressed." [PRO:KRC] comment: Category=organism-sequence. Evidence=Detected by Western blot in all tissues tested (testis, liver, heart, brain, kidney, lung, muscle). synonym: "mLKB1L" EXACT [] synonym: "mLKB1(L)" EXACT [] synonym: "mSTK11/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9WTK7-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000036874 ! serine/threonine-protein kinase STK11 isoform 1 [Term] id: PR:Q9WTK7-3 name: serine/threonine-protein kinase STK11 isoform m3 (mouse) def: "A serine/threonine-protein kinase STK11 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-3." [PRO:DNx, UniProtKB:Q9WTK7] comment: Category=organism-sequence. synonym: "mSTK11/iso:m3" EXACT PRO-short-label [PRO:DNx] synonym: "serine/threonine-protein kinase STK11 isoform STK11N (mouse)" EXACT [UniProtKB:Q9WTK7] xref: UniProtKB:Q9WTK7-3 is_a: PR:Q9WTK7 ! serine/threonine-protein kinase STK11 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q9WTK7-2 name: serine/threonine-protein kinase STK11 isoform 2 (mouse) def: "A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of mouse. This isoform is shorter than isoform 1 at the C-terminal region due to usage of exon IXb. This isoform has predominant expression in the testis." [PMID:18854309, PRO:KRC] comment: Category=organism-sequence. Evidence=Detected by Western blot as p48 isoform in testis, but not in any other tissue tested (liver, heart, brain, kidney, lung, muscle). synonym: "mLKB1S" EXACT [PMID:18854309] synonym: "mLKB1(S)" EXACT [] synonym: "mSTK11/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9WTK7-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000036876 ! serine/threonine-protein kinase STK11 isoform 2