[Term]
id: PR:O43278-2
name: Kunitz-type protease inhibitor 1 isoform h2 (human)
def: "A Kunitz-type protease inhibitor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43278-2." [PRO:DNx, UniProtKB:O43278]
comment: Category=organism-sequence.
synonym: "hSPINT1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kunitz-type protease inhibitor 1 isoform HAI-1A (human)" EXACT [UniProtKB:O43278]
xref: UniProtKB:O43278-2
is_a: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43278-1
name: Kunitz-type protease inhibitor 1 isoform h1 (human)
def: "A Kunitz-type protease inhibitor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43278-1." [PRO:DNx, UniProtKB:O43278]
comment: Category=organism-sequence.
synonym: "hSPINT1/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "Kunitz-type protease inhibitor 1 isoform HAI-1B (human)" EXACT [UniProtKB:O43278]
xref: UniProtKB:O43278-1
is_a: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050737
name: Kunitz-type protease inhibitor 1 O-glycosylated 1 (human)
def: "A Kunitz-type protease inhibitor 1 (human) that has been O-glycosylated at the residue equivalent to Thr-317 of the amino acid sequence represented by UniProtKB:O43278-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O43278-1, Thr-317, MOD:00005~GNO:G43417UB." [GlyGen:O43278-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSPINT1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43278-1, Thr-317, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000015542
name: Kunitz-type protease inhibitor 1
def: "A protein that is a translation product of the human SPINT1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HAI1" RELATED Gene-based []
synonym: "HAI-1" EXACT []
synonym: "SPINT1" EXACT PRO-short-label [PRO:DNx]
synonym: "UNQ223/PRO256" RELATED Gene-based []
synonym: "hepatocyte growth factor activator inhibitor type 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000049326
name: Kunitz-type protease inhibitor 1, signal peptide removed form (human)
def: "A Kunitz-type protease inhibitor 1 (human) that has had the signal peptide removed. UniProtKB:O43278, 36-529." [PRO:DNx, Reactome:R-HSA-6800232]
comment: Category=organism-modification.
synonym: "PRO_0000016883" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSPINT1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43278, 36-529" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6800232 "PR:000049326 located_in GO:0005576"
intersection_of: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050739
name: Kunitz-type protease inhibitor 1 O-glycosylated 3 (human)
def: "A Kunitz-type protease inhibitor 1 (human) that has been O-glycosylated at the residue equivalent to Thr-373 of the amino acid sequence represented by UniProtKB:O43278-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O43278-1, Thr-373, MOD:00005~GNO:G43417UB." [GlyGen:O43278-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSPINT1/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43278-1, Thr-373, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43278
name: Kunitz-type protease inhibitor 1 (human)
def: "A Kunitz-type protease inhibitor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43278]
comment: Category=organism-gene.
synonym: "HAI1" RELATED Gene-based [UniProtKB:O43278]
synonym: "SPINT1" RELATED Gene-based [UniProtKB:O43278]
synonym: "hSPINT1" EXACT PRO-short-label [PRO:DNx]
synonym: "HAI-1 (human)" EXACT [UniProtKB:O43278]
synonym: "UNQ223/PRO256" RELATED Gene-based [UniProtKB:O43278]
synonym: "hepatocyte growth factor activator inhibitor type 1 (human)" EXACT [UniProtKB:O43278]
xref: UniProtKB:O43278
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015542 ! Kunitz-type protease inhibitor 1
relationship: has_gene_template HGNC:11246 ! SPINT1 (human)

[Term]
id: PR:000050738
name: Kunitz-type protease inhibitor 1 O-glycosylated 2 (human)
def: "A Kunitz-type protease inhibitor 1 (human) that has been O-glycosylated at the residue equivalent to Thr-334 of the amino acid sequence represented by UniProtKB:O43278-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O43278-1, Thr-334, MOD:00005~GNO:G43417UB." [GlyGen:O43278-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSPINT1/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43278-1, Thr-334, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O43278 ! Kunitz-type protease inhibitor 1 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens