[Term]
id: PR:Q91V26
name: sphingosine kinase 1 (rat)
def: "A sphingosine kinase 1 that is encoded in the genome of rat." [OMA:Q91V26, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sphk1" RELATED Gene-based [UniProtKB:Q91V26]
synonym: "rSPHK1" EXACT PRO-short-label [PRO:DNx]
synonym: "SK 1 (rat)" EXACT [UniProtKB:Q91V26]
synonym: "SPK 1 (rat)" EXACT [UniProtKB:Q91V26]
synonym: "acetyltransferase SPHK1 (rat)" EXACT [UniProtKB:Q91V26]
xref: UniProtKB:Q91V26
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000015522 ! sphingosine kinase 1
relationship: has_gene_template RGD:620048 ! Sphk1 (rat)

[Term]
id: PR:Q9NYA1-3
name: sphingosine kinase 1 isoform h3 (human)
def: "A sphingosine kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYA1-3." [PRO:DNx, UniProtKB:Q9NYA1]
comment: Category=organism-sequence.
synonym: "hSPHK1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NYA1-3
is_a: PR:Q9NYA1 ! sphingosine kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NYA1-1
name: sphingosine kinase 1 isoform h1 (human)
def: "A sphingosine kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYA1-1." [PRO:DNx, UniProtKB:Q9NYA1]
comment: Category=organism-sequence.
synonym: "hSPHK1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NYA1-1
is_a: PR:Q9NYA1 ! sphingosine kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14159
name: sphingoid long chain base kinase 4 (Schizosaccharomyces pombe 972h-)
def: "A sphingosine kinase 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O14159, PRO:DNx]
comment: Category=organism-gene.
synonym: "lcb4" RELATED Gene-based [UniProtKB:O14159]
synonym: "SPAC4A8.07c" RELATED Gene-based [UniProtKB:O14159]
synonym: "Spom972h-SPHK1" EXACT PRO-short-label [PRO:DNx]
synonym: "LCB kinase 4 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O14159]
synonym: "sphinganine kinase 4 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O14159]
xref: UniProtKB:O14159
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000015522 ! sphingosine kinase 1
relationship: has_gene_template PomBase:SPAC4A8.07c ! lcb4 (Schizosaccharomyces pombe)

[Term]
id: PR:Q18425-1
name: sphingosine kinase 1 isoform a (worm)
def: "A sphingosine kinase 1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q18425-1." [PRO:DNx, UniProtKB:Q18425]
comment: Category=organism-sequence.
synonym: "SPHK1/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q18425-1
is_a: PR:Q18425 ! sphingosine kinase 1 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q18425-3
name: sphingosine kinase 1 isoform c (worm)
def: "A sphingosine kinase 1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q18425-3." [PRO:DNx, UniProtKB:Q18425]
comment: Category=organism-sequence.
synonym: "SPHK1/iso:c (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q18425-3
is_a: PR:Q18425 ! sphingosine kinase 1 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q18425-2
name: sphingosine kinase 1 isoform b (worm)
def: "A sphingosine kinase 1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q18425-2." [PRO:DNx, UniProtKB:Q18425]
comment: Category=organism-sequence.
synonym: "SPHK1/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q18425-2
is_a: PR:Q18425 ! sphingosine kinase 1 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q8CI15-1
name: sphingosine kinase 1 isoform m1 (mouse)
def: "A sphingosine kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CI15-1." [PRO:DNx, UniProtKB:Q8CI15]
comment: Category=organism-sequence.
synonym: "mSPHK1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CI15-1
is_a: PR:Q8CI15 ! sphingosine kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q18425-4
name: sphingosine kinase 1 isoform d (worm)
def: "A sphingosine kinase 1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q18425-4." [PRO:DNx, UniProtKB:Q18425]
comment: Category=organism-sequence.
synonym: "SPHK1/iso:d (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q18425-4
is_a: PR:Q18425 ! sphingosine kinase 1 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q8CI15-3
name: sphingosine kinase 1 isoform m3 (mouse)
def: "A sphingosine kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CI15-3." [PRO:DNx, UniProtKB:Q8CI15]
comment: Category=organism-sequence.
synonym: "mSPHK1/iso:m3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CI15-3
is_a: PR:Q8CI15 ! sphingosine kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8CI15-2
name: sphingosine kinase 1 isoform m2 (mouse)
def: "A sphingosine kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CI15-2." [PRO:DNx, UniProtKB:Q8CI15]
comment: Category=organism-sequence.
synonym: "mSPHK1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CI15-2
is_a: PR:Q8CI15 ! sphingosine kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q18425
name: sphingosine kinase 1 (worm)
def: "A sphingosine kinase 1 that is encoded in the genome of worm." [OMA:Q18425, PRO:DNx]
comment: Category=organism-gene.
synonym: "sphk-1" RELATED Gene-based [UniProtKB:Q18425]
synonym: "C34C6.5" RELATED Gene-based [UniProtKB:Q18425]
synonym: "tag-274" RELATED Gene-based [UniProtKB:Q18425]
synonym: "SPHK1 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q18425
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000015522 ! sphingosine kinase 1
relationship: has_gene_template WormBase:WBGene00007918 ! sphk-1 (worm)

[Term]
id: PR:000015522
name: sphingosine kinase 1
def: "A protein that is a translation product of the human SPHK1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SK1" RELATED Gene-based []
synonym: "SPK" RELATED Gene-based []
synonym: "SK 1" RELATED []
synonym: "SPHK" RELATED Gene-based []
synonym: "SPHK1" EXACT PRO-short-label [PRO:DNx]
synonym: "SPK 1" EXACT []
synonym: "acetyltransferase SPHK1" EXACT []
xref: IUPHARobj:2204
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9NYA1
name: sphingosine kinase 1 (human)
def: "A sphingosine kinase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NYA1]
comment: Category=organism-gene.
synonym: "SK1" RELATED Gene-based [UniProtKB:Q9NYA1]
synonym: "SPK" RELATED Gene-based [UniProtKB:Q9NYA1]
synonym: "SPHK" RELATED Gene-based [UniProtKB:Q9NYA1]
synonym: "SPHK1" RELATED Gene-based [UniProtKB:Q9NYA1]
synonym: "hSPHK1" EXACT PRO-short-label [PRO:DNx]
synonym: "SK 1 (human)" BROAD [UniProtKB:Q9NYA1]
synonym: "SPK 1 (human)" EXACT [UniProtKB:Q9NYA1]
synonym: "acetyltransferase SPHK1 (human)" EXACT [UniProtKB:Q9NYA1]
xref: UniProtKB:Q9NYA1
xref: Reactome:R-HSA-391267 "PR:Q9NYA1 located_in GO:0005829"
xref: DTO:03100482
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015522 ! sphingosine kinase 1
relationship: has_gene_template HGNC:11240 ! SPHK1 (human)

[Term]
id: PR:000046074
name: sphingosine kinase 1 phosphorylated 1 (human)
def: "A sphingosine kinase 1 (human) that has been phosphorylated at the position equivalent to Ser-225 of the amino acid sequence represented by UniProtKB:Q9NYA1-1. Example: UniProtKB:Q9NYA1-1, Ser-225, MOD:00046." [PMID:14532121, iPTMnet:Q9NYA1]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14532121). Status=unreviewed.
synonym: "hSPHK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NYA1-1, Ser-225, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218716 "PR:000046074 located_in GO:0005829"
is_a: PR:Q9NYA1 ! sphingosine kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8CI15
name: sphingosine kinase 1 (mouse)
def: "A sphingosine kinase 1 that is encoded in the genome of mouse." [OMA:Q8CI15, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sk1" RELATED Gene-based [UniProtKB:Q8CI15]
synonym: "Sphk1" RELATED Gene-based [UniProtKB:Q8CI15]
synonym: "mSPHK1" EXACT PRO-short-label [PRO:DNx]
synonym: "SK 1 (mouse)" RELATED [UniProtKB:Q8CI15]
synonym: "SPK 1 (mouse)" EXACT [UniProtKB:Q8CI15]
synonym: "acetyltransferase SPHK1 (mouse)" EXACT [UniProtKB:Q8CI15]
xref: UniProtKB:Q8CI15
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000015522 ! sphingosine kinase 1
relationship: has_gene_template MGI:1316649 ! Sphk1 (mouse)

[Term]
id: PR:Q9NYA1-2
name: sphingosine kinase 1 isoform h2 (human)
def: "A sphingosine kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYA1-2." [PRO:DNx, UniProtKB:Q9NYA1]
comment: Category=organism-sequence.
synonym: "hSPHK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NYA1-2
is_a: PR:Q9NYA1 ! sphingosine kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens