[Term]
id: PR:000049305
name: alpha-synuclein ubiquitinated form (human)
def: "An alpha-synuclein (human) that includes at least one ubiquitinated lysine. UniProtKB:P37840, MOD:01148." [PRO:DNx, Reactome:R-HSA-5660754]
comment: Category=organism-modification.
synonym: "hSNCA/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37840, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5660754 "PR:000049305 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P37840 ! alpha-synuclein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37840
name: alpha-synuclein (human)
def: "An alpha-synuclein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37840]
comment: Category=organism-gene.
synonym: "NACP" RELATED Gene-based [UniProtKB:P37840]
synonym: "SNCA" RELATED Gene-based [UniProtKB:P37840]
synonym: "PARK1" RELATED Gene-based [UniProtKB:P37840]
synonym: "hSNCA" EXACT PRO-short-label [PRO:DNx]
synonym: "non-A beta component of AD amyloid (human)" EXACT [UniProtKB:P37840]
synonym: "non-A4 component of amyloid precursor (human)" EXACT [UniProtKB:P37840]
xref: Reactome:R-HSA-976954 "PR:P37840 located_in GO:0005576"
xref: Reactome:R-HSA-5658500 "PR:P37840 located_in GO:0005829"
xref: UniProtKB:P37840
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015322 ! alpha-synuclein
relationship: has_gene_template HGNC:11138 ! SNCA (human)

[Term]
id: PR:000015322
name: alpha-synuclein
def: "A protein that is a translation product of the human SNCA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Syn" RELATED Gene-based []
synonym: "NACP" RELATED Gene-based []
synonym: "SNCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PARK1" RELATED Gene-based []
synonym: "non-A beta component of AD amyloid" EXACT []
synonym: "non-A4 component of amyloid precursor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P37840-2
name: alpha-synuclein isoform h2-4 (human)
def: "An alpha-synuclein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37840-2." [PRO:DNx, UniProtKB:P37840]
comment: Category=organism-sequence.
synonym: "hSNCA/iso:h2-4" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-synuclein isoform NACP112 (human)" EXACT [UniProtKB:P37840]
xref: UniProtKB:P37840-2
is_a: PR:P37840 ! alpha-synuclein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37840-3
name: alpha-synuclein isoform h2-5 (human)
def: "An alpha-synuclein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37840-3." [PRO:DNx, UniProtKB:P37840]
comment: Category=organism-sequence.
synonym: "hSNCA/iso:h2-5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P37840-3
is_a: PR:P37840 ! alpha-synuclein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37840-1
name: alpha-synuclein isoform 1 (human)
def: "An alpha-synuclein isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hSNCA/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-synuclein isoform NACP140 (human)" EXACT [UniProtKB:P37840]
xref: UniProtKB:P37840-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039381 ! alpha-synuclein isoform 1

[Term]
id: PR:000045769
name: alpha-synuclein phosphorylated 1 (human)
def: "An alpha-synuclein (human) that has been phosphorylated at the position equivalent to Tyr-125 of the amino acid sequence represented by UniProtKB:P37840-1. Example: UniProtKB:P37840-1, Tyr-125, MOD:00048." [PMID:12893833, iPTMnet:P37840]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12893833). Status=unreviewed.
synonym: "hSNCA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37840-1, Tyr-125, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P37840 ! alpha-synuclein (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens