[Term]
id: PR:000014892
name: NAD-dependent protein deacetylase sirtuin-6
def: "A protein that is a translation product of the human SIRT6 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2L6" RELATED Gene-based []
synonym: "SIR2-like protein 6" EXACT []
synonym: "regulatory protein SIR2 homolog 6" EXACT []
synonym: "NAD-dependent deacetylase sirtuin-6" EXACT []
synonym: "mono-ADP-ribosyltransferase sirtuin-6" EXACT []
xref: IUPHARobj:2712
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8N6T7-1
name: NAD-dependent protein deacetylase sirtuin-6 isoform h1 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T7-1." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-sequence.
synonym: "hSIRT6/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8N6T7-1
is_a: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8N6T7-2
name: NAD-dependent protein deacetylase sirtuin-6 isoform h2 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T7-2." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-sequence.
synonym: "hSIRT6/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8N6T7-2
is_a: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049253
name: NAD-dependent protein deacetylase sirtuin-6, initiator methionine removed form (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that has had the initiator methionine removed. UniProtKB:Q8N6T7, 2-355." [PRO:DNx, Reactome:R-HSA-5685963]
comment: Category=organism-modification.
synonym: "PRO_0000110269" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSIRT6/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8N6T7, 2-355" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5685963 "PR:000049253 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8N6T7
name: NAD-dependent protein deacetylase sirtuin-6 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-gene.
synonym: "SIRT6" RELATED Gene-based [UniProtKB:Q8N6T7]
synonym: "SIR2L6" RELATED Gene-based [UniProtKB:Q8N6T7]
synonym: "hSIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 6 (human)" EXACT [UniProtKB:Q8N6T7]
synonym: "regulatory protein SIR2 homolog 6 (human)" EXACT [UniProtKB:Q8N6T7]
xref: UniProtKB:Q8N6T7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014892 ! NAD-dependent protein deacetylase sirtuin-6
relationship: has_gene_template HGNC:14934 ! SIRT6 (human)