[Term]
id: PR:000049253
name: NAD-dependent protein deacetylase sirtuin-6, initiator methionine removed form (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that has had the initiator methionine removed. UniProtKB:Q8N6T7, 2-355." [PRO:DNx, Reactome:R-HSA-5685963]
comment: Category=organism-modification.
synonym: "PRO_0000110269" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSIRT6/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8N6T7, 2-355" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5685963 "PR:000049253 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8N6T7
name: NAD-dependent protein deacetylase sirtuin-6 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-gene.
synonym: "SIRT6" RELATED Gene-based [UniProtKB:Q8N6T7]
synonym: "SIR2L6" RELATED Gene-based [UniProtKB:Q8N6T7]
synonym: "hSIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 6 (human)" EXACT [UniProtKB:Q8N6T7]
synonym: "regulatory protein SIR2 homolog 6 (human)" EXACT [UniProtKB:Q8N6T7]
xref: UniProtKB:Q8N6T7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014892 ! NAD-dependent protein deacetylase sirtuin-6
relationship: has_gene_template HGNC:14934 ! SIRT6 (human)

[Term]
id: PR:P59941
name: NAD-dependent protein deacetylase sirtuin-6 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of mouse." [OMA:P59941, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sirt6" RELATED Gene-based [UniProtKB:P59941]
synonym: "Sir2l6" RELATED Gene-based [UniProtKB:P59941]
synonym: "mSIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 6 (mouse)" EXACT [UniProtKB:P59941]
synonym: "regulatory protein SIR2 homolog 6 (mouse)" EXACT [UniProtKB:P59941]
xref: UniProtKB:P59941
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014892 ! NAD-dependent protein deacetylase sirtuin-6
relationship: has_gene_template MGI:1354161 ! Sirt6 (mouse)

[Term]
id: PR:Q9VH08
name: NAD-dependent protein deacetylase Sirt6 (fruit fly)
def: "An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of fruit fly." [OMA:Q9VH08, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sirt6" RELATED Gene-based [UniProtKB:Q9VH08]
synonym: "CG6284" RELATED Gene-based [UniProtKB:Q9VH08]
synonym: "fly-SIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 6 (fruit fly)" EXACT [UniProtKB:Q9VH08]
synonym: "regulatory protein SIR2 homolog 6 (fruit fly)" EXACT [UniProtKB:Q9VH08]
xref: UniProtKB:Q9VH08
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000014892 ! NAD-dependent protein deacetylase sirtuin-6
relationship: has_gene_template FlyBase:FBgn0037802 ! Sirt6 (fruit fly)

[Term]
id: PR:000014892
name: NAD-dependent protein deacetylase sirtuin-6
def: "A protein that is a translation product of the human SIRT6 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SIRT6" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2L6" RELATED Gene-based []
synonym: "SIR2-like protein 6" EXACT []
synonym: "regulatory protein SIR2 homolog 6" EXACT []
synonym: "NAD-dependent deacetylase sirtuin-6" EXACT []
synonym: "mono-ADP-ribosyltransferase sirtuin-6" EXACT []
xref: IUPHARobj:2712
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8N6T7-1
name: NAD-dependent protein deacetylase sirtuin-6 isoform h1 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T7-1." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-sequence.
synonym: "hSIRT6/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8N6T7-1
is_a: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8N6T7-2
name: NAD-dependent protein deacetylase sirtuin-6 isoform h2 (human)
def: "An NAD-dependent protein deacetylase sirtuin-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T7-2." [PRO:DNx, UniProtKB:Q8N6T7]
comment: Category=organism-sequence.
synonym: "hSIRT6/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8N6T7-2
is_a: PR:Q8N6T7 ! NAD-dependent protein deacetylase sirtuin-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q95Q89
name: NAD-dependent protein deacetylase sir-2.4 (worm)
def: "An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of worm." [OMA:Q95Q89, PRO:DNx]
comment: Category=organism-gene.
synonym: "sir-2.4" RELATED Gene-based [UniProtKB:Q95Q89]
synonym: "C06A5.11" RELATED Gene-based [UniProtKB:Q95Q89]
synonym: "SIRT6 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 4 (worm)" EXACT [UniProtKB:Q95Q89]
synonym: "regulatory protein SIR2 homolog 4 (worm)" EXACT [UniProtKB:Q95Q89]
xref: UniProtKB:Q95Q89
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000014892 ! NAD-dependent protein deacetylase sirtuin-6
relationship: has_gene_template WormBase:WBGene00004803 ! sir-2.4 (worm)