[Term]
id: PR:000050034
name: NAD-dependent protein deacetylase sirtuin-1 isoform m1 phosphorylated 1 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse) that has been phosphorylated at Thr-522. UniProtKB:Q923E4-1, Thr-522, MOD:00047." [PMID:28364022, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:28364022).
synonym: "mSIRT1 phospho-T522" EXACT [PMID:28364022]
synonym: "mSIRT1/iso:m1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q923E4-1, Thr-522, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q923E4-1 ! NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000050035
name: NAD-dependent protein deacetylase sirtuin-1 isoform m1 unphosphorylated 1 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse) that lacks phosphorylation at Thr-522. UniProtKB:Q923E4-1, Thr-522, PR:000026291." [PMID:28364022, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:28364022).
synonym: "mSIRT1/iso:m1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q923E4-1, Thr-522, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q923E4-1 ! NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049252
name: NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form (human)
def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that has had the initiator methionine removed. UniProtKB:Q96EB6, 2-747." [PRO:DNx, Reactome:R-HSA-427531]
comment: Category=organism-modification.
synonym: "PRO_0000110256" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSIRT1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96EB6, 2-747" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-427531 "PR:000049252 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96EB6-2
name: NAD-dependent protein deacetylase sirtuin-1 isoform h2 (human)
def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-2." [PRO:DNx, UniProtKB:Q96EB6]
comment: Category=organism-sequence.
synonym: "hSIRT1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "NAD-dependent protein deacetylase sirtuin-1 isoform delta-exon8 (human)" EXACT [UniProtKB:Q96EB6]
xref: UniProtKB:Q96EB6-2
is_a: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q923E4-1
name: NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q923E4-1." [PRO:DNx, UniProtKB:Q923E4]
comment: Category=organism-sequence.
synonym: "mSIRT1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q923E4-1
is_a: PR:Q923E4 ! NAD-dependent protein deacetylase sirtuin-1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q923E4-2
name: NAD-dependent protein deacetylase sirtuin-1 isoform m2 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q923E4-2." [PRO:DNx, UniProtKB:Q923E4]
comment: Category=organism-sequence.
synonym: "mSIRT1/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "NAD-dependent protein deacetylase sirtuin-1 isoform delta-exon8 (mouse)" EXACT [UniProtKB:Q923E4]
xref: UniProtKB:Q923E4-2
is_a: PR:Q923E4 ! NAD-dependent protein deacetylase sirtuin-1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000021480
name: NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form
def: "An NAD-dependent protein deacetylase sirtuin-1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SIRT1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000014888 ! NAD-dependent protein deacetylase sirtuin-1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q96EB6
name: NAD-dependent protein deacetylase sirtuin-1 (human)
def: "An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96EB6]
comment: Category=organism-gene.
synonym: "SIRT1" RELATED Gene-based [UniProtKB:Q96EB6]
synonym: "hSIR2" EXACT [UniProtKB:Q96EB6]
synonym: "SIR2L1" RELATED Gene-based [UniProtKB:Q96EB6]
synonym: "hSIRT1" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2-like protein 1 (human)" EXACT [UniProtKB:Q96EB6]
synonym: "regulatory protein SIR2 homolog 1 (human)" EXACT [UniProtKB:Q96EB6]
synonym: "NAD-dependent protein deacylase sirtuin-1 (human)" EXACT [UniProtKB:Q96EB6]
xref: UniProtKB:Q96EB6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014888 ! NAD-dependent protein deacetylase sirtuin-1
relationship: has_gene_template HGNC:14929 ! SIRT1 (human)

[Term]
id: PR:Q96EB6-1
name: NAD-dependent protein deacetylase sirtuin-1 isoform h1 (human)
def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-1." [PRO:DNx, UniProtKB:Q96EB6]
comment: Category=organism-sequence.
synonym: "hSIRT1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96EB6-1
is_a: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q923E4
name: NAD-dependent protein deacetylase sirtuin-1 (mouse)
def: "An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of mouse." [OMA:Q923E4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sirt1" RELATED Gene-based [UniProtKB:Q923E4]
synonym: "Sir2l1" RELATED Gene-based [UniProtKB:Q923E4]
synonym: "mSIR2a" EXACT [UniProtKB:Q923E4]
synonym: "mSIRT1" EXACT PRO-short-label [PRO:DNx]
synonym: "Sir2 (mouse)" EXACT [UniProtKB:Q923E4]
synonym: "SIR2alpha (mouse)" EXACT [UniProtKB:Q923E4]
synonym: "SIR2-like protein 1 (mouse)" EXACT [UniProtKB:Q923E4]
synonym: "regulatory protein SIR2 homolog 1 (mouse)" EXACT [UniProtKB:Q923E4]
synonym: "NAD-dependent protein deacylase sirtuin-1 (mouse)" EXACT [UniProtKB:Q923E4]
xref: UniProtKB:Q923E4
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014888 ! NAD-dependent protein deacetylase sirtuin-1
relationship: has_gene_template MGI:2135607 ! Sirt1 (mouse)

[Term]
id: PR:000014888
name: NAD-dependent protein deacetylase sirtuin-1
def: "A protein that is a translation product of the human SIRT1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "sir2" EXACT []
synonym: "SIR2a" EXACT []
synonym: "SIRT1" EXACT PRO-short-label [PRO:DNx]
synonym: "SIR2L1" RELATED Gene-based []
synonym: "SIR2alpha" EXACT []
synonym: "SIR2-like protein 1" EXACT []
synonym: "regulatory protein SIR2 homolog 1" EXACT []
synonym: "NAD-dependent deacetylase sirtuin-1" EXACT []
synonym: "NAD-dependent protein deacylase sirtuin-1" EXACT []
xref: IUPHARobj:2707
is_a: PR:000000001 ! protein

[Term]
id: PR:A0A0G2JZ79
name: NAD-dependent protein deacetylase sirtuin-1 (rat)
def: "An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of rat." [OMA:A0A0G2JZ79, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sirt1" RELATED Gene-based [UniProtKB:A0A0G2JZ79]
synonym: "rSIRT1" EXACT PRO-short-label [PRO:DNx]
synonym: "NAD-dependent protein deacylase sirtuin-1 (rat)" EXACT [UniProtKB:A0A0G2JZ79]
xref: UniProtKB:A0A0G2JZ79
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000014888 ! NAD-dependent protein deacetylase sirtuin-1
relationship: has_gene_template RGD:1308542 ! Sirt1 (rat)