[Term]
id: PR:P34896-4
name: serine hydroxymethyltransferase, cytosolic isoform h4 (human)
def: "A serine hydroxymethyltransferase, cytosolic (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34896-4." [PRO:DNx, UniProtKB:P34896]
comment: Category=organism-sequence.
synonym: "hSHMT1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34896-4
is_a: PR:P34896 ! serine hydroxymethyltransferase, cytosolic (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P34896-2
name: serine hydroxymethyltransferase, cytosolic isoform h2 (human)
def: "A serine hydroxymethyltransferase, cytosolic (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34896-2." [PRO:DNx, UniProtKB:P34896]
comment: Category=organism-sequence.
synonym: "hSHMT1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34896-2
is_a: PR:P34896 ! serine hydroxymethyltransferase, cytosolic (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P34896-3
name: serine hydroxymethyltransferase, cytosolic isoform h3 (human)
def: "A serine hydroxymethyltransferase, cytosolic (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34896-3." [PRO:DNx, UniProtKB:P34896]
comment: Category=organism-sequence.
synonym: "hSHMT1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34896-3
is_a: PR:P34896 ! serine hydroxymethyltransferase, cytosolic (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P34896-1
name: serine hydroxymethyltransferase, cytosolic isoform h1 (human)
def: "A serine hydroxymethyltransferase, cytosolic (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34896-1." [PRO:DNx, UniProtKB:P34896]
comment: Category=organism-sequence.
synonym: "hSHMT1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34896-1
is_a: PR:P34896 ! serine hydroxymethyltransferase, cytosolic (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P34896
name: serine hydroxymethyltransferase, cytosolic (human)
def: "A serine hydroxymethyltransferase, cytosolic that is encoded in the genome of human." [PRO:DNx, UniProtKB:P34896]
comment: Category=organism-gene.
synonym: "SHMT1" RELATED Gene-based [UniProtKB:P34896]
synonym: "hSHMT1" EXACT PRO-short-label [PRO:DNx]
synonym: "SHMT (human)" BROAD [UniProtKB:P34896]
synonym: "serine methylase (human)" BROAD [UniProtKB:P34896]
synonym: "glycine hydroxymethyltransferase (human)" BROAD [UniProtKB:P34896]
xref: UniProtKB:P34896
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014847 ! serine hydroxymethyltransferase, cytosolic
relationship: has_gene_template HGNC:10850 ! SHMT1 (human)

[Term]
id: PR:000049236
name: serine hydroxymethyltransferase, cytosolic, initiator methionine removed pyridoxal phosphate lysine 1 (human)
def: "A serine hydroxymethyltransferase, cytosolic (human) that has had the initiator methionine removed and has been post-translationally modified to include pyridoxal phosphate lysine at position 257 of the amino acid sequence represented by UniProtKB:P34896. UniProtKB:P34896, 2-483, Lys-257, MOD:00128." [PRO:DNx, Reactome:R-HSA-71242]
comment: Category=organism-modification.
synonym: "hSHMT1/InitMet-/Pyrdox:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000113504, Lys-257, MOD:00128" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P34896, 2-483, Lys-257, MOD:00128" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-71242 "PR:000049236 located_in GO:0005829"
is_a: PR:P34896 ! serine hydroxymethyltransferase, cytosolic (human)
relationship: has_part MOD:00128 ! N6-pyridoxal phosphate-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000014847
name: serine hydroxymethyltransferase, cytosolic
def: "A protein that is a translation product of the human SHMT1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SHMT" BROAD [PRO:DNx]
synonym: "SHMT1" EXACT PRO-short-label [PRO:DNx]
synonym: "serine methylase" BROAD [PRO:DNx]
synonym: "glycine hydroxymethyltransferase" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein