[Term]
id: PR:Q92008
name: sonic hedgehog protein A (zebrafish)
def: "A sonic hedgehog protein that is encoded in the genome of zebrafish." [OMA:Q92008, PANTHER:PTHR11889:SF16, PRO:DNx]
comment: Category=organism-gene.
synonym: "shh" RELATED Gene-based [UniProtKB:Q92008]
synonym: "shha" RELATED Gene-based [UniProtKB:Q92008]
synonym: "vhh1" RELATED Gene-based [UniProtKB:Q92008]
synonym: "z-SHH" EXACT PRO-short-label [PRO:DNx]
synonym: "SHHA (zebrafish)" EXACT [UniProtKB:Q92008]
synonym: "ShhNC (zebrafish)" EXACT [UniProtKB:Q92008]
synonym: "VHH-1 (zebrafish)" EXACT [UniProtKB:Q92008]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (zebrafish)" EXACT [UniProtKB:Q92008]
xref: UniProtKB:Q92008
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000014841 ! sonic hedgehog protein
relationship: has_gene_template ZFIN:ZDB-GENE-980526-166 ! shha (zebrafish)

[Term]
id: PR:Q15465
name: sonic hedgehog protein (human)
def: "A sonic hedgehog protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15465]
comment: Category=organism-gene.
synonym: "SHH" RELATED Gene-based [UniProtKB:Q15465]
synonym: "hSHH" EXACT PRO-short-label [PRO:DNx]
synonym: "HHG-1 (human)" EXACT [UniProtKB:Q15465]
synonym: "ShhNC (human)" EXACT [UniProtKB:Q15465]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (human)" EXACT [UniProtKB:Q15465]
xref: UniProtKB:Q15465
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014841 ! sonic hedgehog protein
relationship: has_gene_template HGNC:10848 ! SHH (human)

[Term]
id: PR:Q91035
name: sonic hedgehog protein (chicken)
def: "A sonic hedgehog protein that is encoded in the genome of chicken." [OMA:Q91035, PANTHER:PTHR11889:SF16, PRO:DNx]
comment: Category=organism-gene.
synonym: "SHH" RELATED Gene-based [UniProtKB:Q91035]
synonym: "chick-SHH" EXACT PRO-short-label [PRO:DNx]
synonym: "ShhNC (chicken)" EXACT [UniProtKB:Q91035]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (chicken)" EXACT [UniProtKB:Q91035]
xref: UniProtKB:Q91035
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000014841 ! sonic hedgehog protein
relationship: has_gene_template NCBIGene:395615 ! SHH (chicken)

[Term]
id: PR:000037269
name: sonic hedgehog protein N-product dually lipidated 1 (mouse)
def: "A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]
comment: Category=organism-modification.
synonym: "mSHH/Clv:Nter/2*Lipid:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000037273 ! sonic hedgehog protein N-product
relationship: has_part MOD:00069 ! N-palmitoyl-L-cysteine
relationship: has_part MOD:00314 ! glycine cholesterol ester
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000014841
name: sonic hedgehog protein
def: "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SHH" EXACT PRO-short-label [PRO:DNx]
synonym: "Hhg1" RELATED Gene-based []
synonym: "HHG-1" EXACT []
synonym: "ShhNC" EXACT []
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000037275
name: sonic hedgehog protein C-product
def: "A sonic hedgehog protein, signal peptide removed form that is the C-terminal product after autolysis. The C-product has autoproteolysis activity but does not participate in signal transduction." [PMID:24342078, PRO:CNA]
comment: Category=modification.
synonym: "SHH/Clv:Cter" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021467 ! sonic hedgehog protein, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:Q62226
name: sonic hedgehog protein (mouse)
def: "A sonic hedgehog protein that is encoded in the genome of mouse." [OMA:Q62226, PRO:DNx]
comment: Category=organism-gene.
synonym: "Shh" RELATED Gene-based [UniProtKB:Q62226]
synonym: "Hhg1" RELATED Gene-based [UniProtKB:Q62226]
synonym: "mSHH" EXACT PRO-short-label [PRO:DNx]
synonym: "SHH (mouse)" EXACT [UniProtKB:Q62226]
synonym: "HHG-1 (mouse)" EXACT [UniProtKB:Q62226]
synonym: "ShhNC (mouse)" EXACT [UniProtKB:Q62226]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)" EXACT [UniProtKB:Q62226]
xref: UniProtKB:Q62226
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014841 ! sonic hedgehog protein
relationship: has_gene_template MGI:98297 ! Shh (mouse)

[Term]
id: PR:000021468
name: sonic hedgehog protein proteolytic cleavage product
def: "A sonic hedgehog protein that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "SHH/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000014841 ! sonic hedgehog protein

[Term]
id: PR:000021467
name: sonic hedgehog protein, signal peptide removed form
def: "A sonic hedgehog protein that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "SHH/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000014841 ! sonic hedgehog protein
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000037274
name: sonic hedgehog protein N-product dually lipidated 1 (human)
def: "A sonic hedgehog protein N-product in human that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314." [PMID:9593755, PRO:CNA]
comment: Category=organism-modification. Enzyme=("HHAT"; PR:Q5VTY9).
synonym: "hSHH/Clv:Nter/2*Lipid:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000037273 ! sonic hedgehog protein N-product
relationship: has_part MOD:00069 ! N-palmitoyl-L-cysteine
relationship: has_part MOD:00314 ! glycine cholesterol ester
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q63673
name: sonic hedgehog protein (rat)
def: "A sonic hedgehog protein that is encoded in the genome of rat." [PANTHER:PTHR11889:SF16, PRO:DNx]
comment: Category=organism-gene.
synonym: "Shh" RELATED Gene-based [UniProtKB:Q63673]
synonym: "rSHH" EXACT PRO-short-label [PRO:DNx]
synonym: "Vhh-1" RELATED Gene-based [UniProtKB:Q63673]
synonym: "SHH (rat)" EXACT [UniProtKB:Q63673]
synonym: "ShhNC (rat)" EXACT [UniProtKB:Q63673]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (rat)" EXACT [UniProtKB:Q63673]
xref: UniProtKB:Q63673
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000014841 ! sonic hedgehog protein
relationship: has_gene_template RGD:3673 ! Shh (rat)

[Term]
id: PR:000037273
name: sonic hedgehog protein N-product
def: "A sonic hedgehog protein, signal peptide removed form that is the N-terminal product after autolysis. The N-product is the active species in signal transduction." [PRO:CNA]
comment: Category=modification.
synonym: "SHH-N" EXACT []
synonym: "SHH/Clv:Nter" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021467 ! sonic hedgehog protein, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000037272
name: sonic hedgehog protein, signal peptide removed form (mouse)
def: "A sonic hedgehog protein, signal peptide removed form in mouse. UniProtKB:Q62226, 25-437." [PMID:18794898, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSHH/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013211" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q62226, 25-437" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021467 ! sonic hedgehog protein, signal peptide removed form