[Term]
id: PR:000045705
name: retinoic acid receptor RXR-alpha phosphorylated 1 (human)
def: "A retinoic acid receptor RXR-alpha (human) that has been phosphorylated at the position equivalent to Ser-260 of the amino acid sequence represented by UniProtKB:P19793-1. Example: UniProtKB:P19793-1, Ser-260, MOD:00046." [PMID:10377179, iPTMnet:P19793]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10377179). Status=unreviewed.
synonym: "hRXRA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19793-1, Ser-260, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P19793 ! retinoic acid receptor RXR-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P28700
name: retinoic acid receptor RXR-alpha (mouse)
def: "A retinoic acid receptor RXR-alpha that is encoded in the genome of mouse." [OMA:P28700, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rxra" RELATED Gene-based [UniProtKB:P28700]
synonym: "Nr2b1" RELATED Gene-based [UniProtKB:P28700]
synonym: "mRXRA" EXACT PRO-short-label [PRO:DNx]
synonym: "retinoid X receptor alpha (mouse)" EXACT [UniProtKB:P28700]
synonym: "nuclear receptor subfamily 2 group B member 1 (mouse)" EXACT [UniProtKB:P28700]
xref: UniProtKB:P28700
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_gene_template MGI:98214 ! Rxra (mouse)

[Term]
id: PR:Q05343
name: retinoic acid receptor RXR-alpha (rat)
def: "A retinoic acid receptor RXR-alpha that is encoded in the genome of rat." [OMA:Q05343, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "Rxra" RELATED Gene-based [UniProtKB:Q05343]
synonym: "Nr2b1" RELATED Gene-based [UniProtKB:Q05343]
synonym: "rRXRA" EXACT PRO-short-label [PRO:DNx]
synonym: "retinoid X receptor alpha (rat)" EXACT [UniProtKB:Q05343]
synonym: "nuclear receptor subfamily 2 group B member 1 (rat)" EXACT [UniProtKB:Q05343]
xref: UniProtKB:Q05343
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_gene_template RGD:3610 ! Rxra (rat)

[Term]
id: PR:P19793-1
name: retinoic acid receptor RXR-alpha isoform 1 (human)
def: "A retinoic acid receptor RXR-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19793-1." [PRO:DNx, UniProtKB:P19793]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hRXRA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19793-1
is_a: PR:P19793 ! retinoic acid receptor RXR-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19793-2
name: retinoic acid receptor RXR-alpha isoform h2 (human)
def: "A retinoic acid receptor RXR-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19793-2." [PRO:DNx, UniProtKB:P19793]
comment: Category=organism-sequence.
synonym: "hRXRA/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19793-2
is_a: PR:P19793 ! retinoic acid receptor RXR-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000014372
name: retinoic acid receptor RXR-alpha
def: "A protein that is a translation product of the human RXRA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RXRA" EXACT PRO-short-label [PRO:DNx]
synonym: "NR2B1" RELATED Gene-based []
synonym: "retinoid X receptor alpha" EXACT []
synonym: "nuclear receptor subfamily 2 group B member 1" EXACT []
xref: IUPHARobj:610
is_a: PR:000000001 ! protein

[Term]
id: PR:Q6LC96
name: retinoic acid receptor RXR-alpha isoform 2 (mouse)
def: "A retinoic acid receptor RXR-alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6LC96." [PMID:8954108, PRO:KRC]
comment: Category=organism-sequence. Note: PMID:8954108 shows that RNAse protection identified the presence of the full length Rxr-alpha transcript in all tissues assayed, and a smaller transcript present in testis and at a low level in liver. RACE-PCR followed by cloning and sequencing identified the full length cDNA encoding protein isoform 1, and also two shorter cDNAs with differing 5' ends, 1 clone of Rxr-alpha-2 and 15 clones of Rxr-alpha-3. Analysis of the sequence of the alpha-2 and alpha-3 transcripts indicated that they both code for the same protein with an ATG start codon present in the sequence of exon 2.
synonym: "mRXRA/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "RXR-alpha2 (mouse)" EXACT [PMID:8954108]
synonym: "RXR-alpha3 (mouse)" EXACT [PMID:8954108]
synonym: "RXR-alpha2/3 (mouse)" EXACT [PMID:8954108]
xref: UniProtKB:Q6LC96
is_a: PR:P28700 ! retinoic acid receptor RXR-alpha (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P19793
name: retinoic acid receptor RXR-alpha (human)
def: "A retinoic acid receptor RXR-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19793]
comment: Category=organism-gene.
synonym: "RXRA" RELATED Gene-based [UniProtKB:P19793]
synonym: "NR2B1" RELATED Gene-based [UniProtKB:P19793]
synonym: "hRXRA" EXACT PRO-short-label [PRO:DNx]
synonym: "retinoid X receptor alpha (human)" EXACT [UniProtKB:P19793]
synonym: "nuclear receptor subfamily 2 group B member 1 (human)" EXACT [UniProtKB:P19793]
xref: Reactome:R-HSA-381319 "PR:P19793 located_in GO:0005654"
xref: Reactome:R-HSA-9619757 "PR:P19793 located_in GO:0005829"
xref: DTO:00117501
xref: UniProtKB:P19793
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_gene_template HGNC:10477 ! RXRA (human)

[Term]
id: PR:P28700-1
name: retinoic acid receptor RXR-alpha isoform 1 (mouse)
def: "A retinoic acid receptor RXR-alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28700-1." [PMID:1312497, PMID:8954108, PRO:KRC, UniProtKB:P28700]
comment: Category=organism-sequence. Note: PMID:1312497 shows sloning of cDNAs for three RXR genes, alpha, beta, and gamma. PMID:8954108 shows that RNAse protection identified the presence of the full length Rxr-alpha transcript in all tissues assayed, and a smaller transcript present in testis and at a low level in liver. RACE-PCR followed by cloning and sequencing identified the full length cDNA encoding protein isoform 1, and also two shorter cDNAs with differing 5' ends, 1 clone of Rxr-alpha-2 and 15 clones of Rxr-alpha-3. Analysis of the sequence of the alpha-2 and alpha-3 transcripts indicated that they both code for the same protein with an ATG start codon present in the sequence of exon 2.
synonym: "mRXRA/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "RXR-alpha1 (mouse)" EXACT []
xref: UniProtKB:P28700-1
is_a: PR:P28700 ! retinoic acid receptor RXR-alpha (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049146
name: retinoic acid receptor RXR-alpha phosphorylated 2 (human)
def: "A retinoic acid receptor RXR-alpha (human) that has been post-translationally modified to include phosphoserine at position 21 of the amino acid sequence represented by UniProtKB:P19793. UniProtKB:P19793, Ser-21, MOD:00046." [PRO:DNx, Reactome:R-HSA-5334811]
comment: Category=organism-modification.
synonym: "hRXRA/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19793, Ser-21, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5334811 "PR:000049146 located_in GO:0005654"
is_a: PR:P19793 ! retinoic acid receptor RXR-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q90415
name: retinoic acid receptor RXR-alpha-B (zebrafish)
def: "A retinoic acid receptor RXR-alpha that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-gene.
synonym: "rxra" RELATED Gene-based [UniProtKB:Q90415]
synonym: "rxrg" RELATED Gene-based [UniProtKB:Q90415]
synonym: "rxrab" RELATED Gene-based [UniProtKB:Q90415]
synonym: "nr2b1b" RELATED Gene-based [UniProtKB:Q90415]
synonym: "z-RXRA" EXACT PRO-short-label [PRO:DNx]
synonym: "retinoid X receptor alpha-B (zebrafish)" EXACT [UniProtKB:Q90415]
synonym: "nuclear receptor subfamily 2 group B member 1-B (zebrafish)" EXACT [UniProtKB:Q90415]
xref: UniProtKB:Q90415
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_gene_template ZFIN:ZDB-GENE-990415-243 ! rxrab (zebrafish)