[Term]
id: PR:Q9UK32
name: ribosomal protein S6 kinase alpha-6 (human)
def: "A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UK32]
comment: Category=organism-gene.
synonym: "RSK4" RELATED Gene-based [UniProtKB:Q9UK32]
synonym: "RPS6KA6" RELATED Gene-based [UniProtKB:Q9UK32]
synonym: "hRPS6KA6" EXACT PRO-short-label [PRO:DNx]
synonym: "RSK-4 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "p90RSK6 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "pp90RSK4 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "p90-RSK 6 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "S6K-alpha-6 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "ribosomal S6 kinase 4 (human)" EXACT [UniProtKB:Q9UK32]
synonym: "90 kDa ribosomal protein S6 kinase 6 (human)" EXACT [UniProtKB:Q9UK32]
xref: UniProtKB:Q9UK32
xref: Reactome:R-HSA-444266 "PR:Q9UK32 located_in GO:0005829"
xref: DTO:03100256
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014287 ! ribosomal protein S6 kinase alpha-6
relationship: has_gene_template HGNC:10435 ! RPS6KA6 (human)

[Term]
id: PR:000049860
name: ribosomal protein S6 kinase alpha-6 unphosphorylated 1 (human)
def: "A ribosomal protein S6 kinase alpha-6 (human) that lacks phosphoserine at positions 232, 372, 389, and phosphothreonine at position 581 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389/Thr-581, PR:000026291." [PMID:15632195, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15632195).
synonym: "hRPS6KA6/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389/Thr-581, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9UK32 ! ribosomal protein S6 kinase alpha-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000014287
name: ribosomal protein S6 kinase alpha-6
def: "A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA6 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RSK4" RELATED Gene-based []
synonym: "RSK-4" EXACT []
synonym: "RPS6KA6" EXACT PRO-short-label [PRO:DNx]
synonym: "p90RSK6" EXACT []
synonym: "pp90RSK4" EXACT []
synonym: "p90-RSK 6" EXACT []
synonym: "S6K-alpha-6" EXACT []
synonym: "ribosomal S6 kinase 4" EXACT []
synonym: "90 kDa ribosomal protein S6 kinase 6" EXACT []
xref: IUPHARobj:1530
is_a: PR:000029187 ! ribosomal protein S6 kinase alpha

[Term]
id: PR:Q9UK32-2
name: ribosomal protein S6 kinase alpha-6 isoform h2 (human)
def: "A ribosomal protein S6 kinase alpha-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UK32-2." [PRO:DNx, UniProtKB:Q9UK32]
comment: Category=organism-sequence.
synonym: "hRPS6KA6/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UK32-2
is_a: PR:Q9UK32 ! ribosomal protein S6 kinase alpha-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9UK32-1
name: ribosomal protein S6 kinase alpha-6 isoform h1 (human)
def: "A ribosomal protein S6 kinase alpha-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UK32-1." [PRO:DNx, UniProtKB:Q9UK32]
comment: Category=organism-sequence.
synonym: "hRPS6KA6/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UK32-1
is_a: PR:Q9UK32 ! ribosomal protein S6 kinase alpha-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049133
name: ribosomal protein S6 kinase alpha-6 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase alpha-6 (human) that has been post-translationally modified to include phosphoserine at positions 232, 372 and 389, and phosphothreonine at position 581 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389, MOD:00046|Thr-581, MOD:00047." [PMID:15632195, PRO:DNx, PRO:KER, Reactome:R-HSA-444293]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15632195). Kinase=("RPS6KA6"; PR:Q9UK32-1; Ser-232/Ser-389). Kinase=("MAPK"; PR:000000019; Ser-372/Thr-581).
synonym: "hRPS6KA6/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389, MOD:00046|Thr-581, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-444293 "PR:000049133 located_in GO:0005654"
is_a: PR:Q9UK32 ! ribosomal protein S6 kinase alpha-6 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens