[Term]
id: PR:000014286
name: ribosomal protein S6 kinase alpha-5
def: "A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MSK1" RELATED Gene-based []
synonym: "RLSK" BROAD [PRO:DNx]
synonym: "RSKL" EXACT []
synonym: "RPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K-alpha-5" EXACT []
synonym: "RSK-like protein kinase" BROAD [PRO:DNx]
synonym: "90 kDa ribosomal protein S6 kinase 5" EXACT []
synonym: "nuclear mitogen- and stress-activated protein kinase 1" EXACT []
xref: IUPHARobj:1523
is_a: PR:000029187 ! ribosomal protein S6 kinase alpha

[Term]
id: PR:O75582-1
name: ribosomal protein S6 kinase alpha-5 isoform 1 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-1." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hRPS6KA5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-1
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582-2
name: ribosomal protein S6 kinase alpha-5 isoform h2 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-2." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence.
synonym: "hRPS6KA5/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-2
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582-3
name: ribosomal protein S6 kinase alpha-5 isoform h3 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-3." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence.
synonym: "hRPS6KA5/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-3
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582
name: ribosomal protein S6 kinase alpha-5 (human)
def: "A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-gene.
synonym: "MSK1" RELATED Gene-based [UniProtKB:O75582]
synonym: "RPS6KA5" RELATED Gene-based [UniProtKB:O75582]
synonym: "hRPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "RSKL (human)" EXACT [UniProtKB:O75582]
synonym: "S6K-alpha-5 (human)" EXACT [UniProtKB:O75582]
synonym: "RSK-like protein kinase (human)" EXACT [UniProtKB:O75582]
synonym: "90 kDa ribosomal protein S6 kinase 5 (human)" EXACT [UniProtKB:O75582]
synonym: "nuclear mitogen- and stress-activated protein kinase 1 (human)" EXACT [UniProtKB:O75582]
xref: Reactome:R-HSA-198657 "PR:O75582 located_in GO:0005654"
xref: Reactome:R-HSA-772525 "PR:O75582 located_in GO:0005829"
xref: DTO:03100255
xref: UniProtKB:O75582
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014286 ! ribosomal protein S6 kinase alpha-5
relationship: has_gene_template HGNC:10434 ! RPS6KA5 (human)

[Term]
id: PR:000045609
name: ribosomal protein S6 kinase alpha-5 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that has been phosphorylated at the position equivalent to Thr-581 of the amino acid sequence represented by UniProtKB:O75582-1. Example: UniProtKB:O75582-1, Thr-581, MOD:00047." [PMID:17429437, iPTMnet:O75582]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17429437). Status=unreviewed.
synonym: "hRPS6KA5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75582-1, Thr-581, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049132
name: ribosomal protein S6 kinase alpha-5 phosphorylated 2 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that has been post-translationally modified to include phosphoserine at positions 212, 360 and 376, and phosphothreonine at position 581 of the amino acid sequence represented by UniProtKB:O75582. UniProtKB:O75582, Ser-212/Ser-360/Ser-376, MOD:00046|Thr-581, MOD:00047." [PRO:DNx, Reactome:R-HSA-198683]
comment: Category=organism-modification.
synonym: "hRPS6KA5/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75582, Ser-212/Ser-360/Ser-376, MOD:00046|Thr-581, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198683 "PR:000049132 located_in GO:0005654"
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens