[Term]
id: PR:Q8C050
name: ribosomal protein S6 kinase alpha-5 (mouse)
def: "A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of mouse." [OMA:MOUSE05119, PRO:DNx]
comment: Category=organism-gene.
synonym: "Msk1" RELATED Gene-based [UniProtKB:Q8C050]
synonym: "Rps6ka5" RELATED Gene-based [UniProtKB:Q8C050]
synonym: "mRPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "RLSK (mouse)" EXACT [UniProtKB:Q8C050]
synonym: "S6K-alpha-5 (mouse)" EXACT [UniProtKB:Q8C050]
synonym: "RSK-like protein kinase (mouse)" EXACT [UniProtKB:Q8C050]
synonym: "90 kDa ribosomal protein S6 kinase 5 (mouse)" EXACT [UniProtKB:Q8C050]
synonym: "nuclear mitogen- and stress-activated protein kinase 1 (mouse)" EXACT [UniProtKB:Q8C050]
xref: UniProtKB:Q8C050
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014286 ! ribosomal protein S6 kinase alpha-5
relationship: has_gene_template MGI:1920336 ! Rps6ka5 (mouse)

[Term]
id: PR:000014286
name: ribosomal protein S6 kinase alpha-5
def: "A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MSK1" RELATED Gene-based []
synonym: "RLSK" BROAD [PRO:DNx]
synonym: "RSKL" EXACT []
synonym: "RPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K-alpha-5" EXACT []
synonym: "RSK-like protein kinase" BROAD [PRO:DNx]
synonym: "90 kDa ribosomal protein S6 kinase 5" EXACT []
synonym: "nuclear mitogen- and stress-activated protein kinase 1" EXACT []
xref: IUPHARobj:1523
is_a: PR:000029187 ! ribosomal protein S6 kinase alpha

[Term]
id: PR:O75582-1
name: ribosomal protein S6 kinase alpha-5 isoform 1 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-1." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hRPS6KA5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-1
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582-2
name: ribosomal protein S6 kinase alpha-5 isoform h2 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-2." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence.
synonym: "hRPS6KA5/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-2
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582-3
name: ribosomal protein S6 kinase alpha-5 isoform h3 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-3." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-sequence.
synonym: "hRPS6KA5/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75582-3
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75582
name: ribosomal protein S6 kinase alpha-5 (human)
def: "A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75582]
comment: Category=organism-gene.
synonym: "MSK1" RELATED Gene-based [UniProtKB:O75582]
synonym: "RPS6KA5" RELATED Gene-based [UniProtKB:O75582]
synonym: "hRPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "RSKL (human)" EXACT [UniProtKB:O75582]
synonym: "S6K-alpha-5 (human)" EXACT [UniProtKB:O75582]
synonym: "RSK-like protein kinase (human)" EXACT [UniProtKB:O75582]
synonym: "90 kDa ribosomal protein S6 kinase 5 (human)" EXACT [UniProtKB:O75582]
synonym: "nuclear mitogen- and stress-activated protein kinase 1 (human)" EXACT [UniProtKB:O75582]
xref: Reactome:R-HSA-198657 "PR:O75582 located_in GO:0005654"
xref: Reactome:R-HSA-772525 "PR:O75582 located_in GO:0005829"
xref: DTO:03100255
xref: UniProtKB:O75582
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014286 ! ribosomal protein S6 kinase alpha-5
relationship: has_gene_template HGNC:10434 ! RPS6KA5 (human)

[Term]
id: PR:000045609
name: ribosomal protein S6 kinase alpha-5 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that has been phosphorylated at the position equivalent to Thr-581 of the amino acid sequence represented by UniProtKB:O75582-1. Example: UniProtKB:O75582-1, Thr-581, MOD:00047." [PMID:17429437, iPTMnet:O75582]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17429437). Status=unreviewed.
synonym: "hRPS6KA5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75582-1, Thr-581, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049132
name: ribosomal protein S6 kinase alpha-5 phosphorylated 2 (human)
def: "A ribosomal protein S6 kinase alpha-5 (human) that has been post-translationally modified to include phosphoserine at positions 212, 360 and 376, and phosphothreonine at position 581 of the amino acid sequence represented by UniProtKB:O75582. UniProtKB:O75582, Ser-212/Ser-360/Ser-376, MOD:00046|Thr-581, MOD:00047." [PRO:DNx, Reactome:R-HSA-198683]
comment: Category=organism-modification.
synonym: "hRPS6KA5/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75582, Ser-212/Ser-360/Ser-376, MOD:00046|Thr-581, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198683 "PR:000049132 located_in GO:0005654"
is_a: PR:O75582 ! ribosomal protein S6 kinase alpha-5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8C050-1
name: ribosomal protein S6 kinase alpha-5 isoform m2 (mouse)
def: "A ribosomal protein S6 kinase alpha-5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C050-1." [PRO:DNx, UniProtKB:Q8C050]
comment: Category=organism-sequence.
synonym: "mRPS6KA5/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8C050-1
is_a: PR:Q8C050 ! ribosomal protein S6 kinase alpha-5 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049841
name: ribosomal protein S6 kinase alpha-5 phosphorylated 1 (mouse)
def: "A ribosomal protein S6 kinase alpha-5 (mouse) that has been phosphorylated at the position equivalent to Thr-645 of the amino acid sequence represented by UniProtKB:Q8C050-1. Example: UniProtKB:Q8C050-1, Thr-645, MOD:00047." [PMID:27998980, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27998980).
synonym: "mRPS6KA5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8C050-1, Thr-645, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8C050 ! ribosomal protein S6 kinase alpha-5 (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8C050-2
name: ribosomal protein S6 kinase alpha-5 isoform m1 (mouse)
def: "A ribosomal protein S6 kinase alpha-5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C050-2." [PRO:DNx, UniProtKB:Q8C050]
comment: Category=organism-sequence.
synonym: "mRPS6KA5/iso:m1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribosomal protein S6 kinase alpha-5 isoform 5 (mouse)" EXACT [UniProtKB:Q8C050]
xref: UniProtKB:Q8C050-2
is_a: PR:Q8C050 ! ribosomal protein S6 kinase alpha-5 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q5F3L1
name: ribosomal protein S6 kinase alpha-5 (chicken)
def: "A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of chicken." [OMA:Q5F3L1, PANTHER:PTHR24351:SF82, PRO:DNx]
comment: Category=organism-gene.
synonym: "RPS6KA5" RELATED Gene-based [UniProtKB:Q5F3L1]
synonym: "RCJMB04_14g1" RELATED Gene-based [UniProtKB:Q5F3L1]
synonym: "chick-RPS6KA5" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K-alpha-5 (chicken)" EXACT [UniProtKB:Q5F3L1]
xref: UniProtKB:Q5F3L1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000014286 ! ribosomal protein S6 kinase alpha-5
relationship: has_gene_template NCBIGene:423408 ! RPS6KA5 (chicken)