[Term]
id: PR:P35546
name: proto-oncogene tyrosine-protein kinase receptor Ret (mouse)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of mouse." [OMA:P35546, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ret" RELATED Gene-based [UniProtKB:P35546]
synonym: "mRET" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene c-Ret (mouse)" EXACT [UniProtKB:P35546]
xref: UniProtKB:P35546
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret
relationship: has_gene_template MGI:97902 ! Ret (mouse)

[Term]
id: PR:G3V9H8-1
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform r1 (rat)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G3V9H8-1." [PRO:DNx, UniProtKB:G3V9H8]
comment: Category=organism-sequence.
synonym: "rRET/iso:r1" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene tyrosine-protein kinase receptor Ret isoform Ret51 (rat)" EXACT [UniProtKB:G3V9H8]
xref: UniProtKB:G3V9H8-1
is_a: PR:G3V9H8 ! proto-oncogene tyrosine-protein kinase receptor Ret (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000037459
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 1
def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35546-1 or a 1:1 ortholog thereof." [PMID:8455936, PRO:HJD]
comment: Category=sequence.
synonym: "RET51" EXACT []
synonym: "RET/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret

[Term]
id: PR:G3V9H8-2
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform r2 (rat)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G3V9H8-2." [PRO:DNx, UniProtKB:G3V9H8]
comment: Category=organism-sequence.
synonym: "rRET/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene tyrosine-protein kinase receptor Ret isoform Ret9 (rat)" EXACT [UniProtKB:G3V9H8]
xref: UniProtKB:G3V9H8-2
is_a: PR:G3V9H8 ! proto-oncogene tyrosine-protein kinase receptor Ret (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P07949-1
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]
comment: Category=organism-sequence.
synonym: "hRET/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "RET51 (human)" EXACT []
xref: UniProtKB:P07949-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037459 ! proto-oncogene tyrosine-protein kinase receptor Ret isoform 1

[Term]
id: PR:000013895
name: proto-oncogene tyrosine-protein kinase receptor Ret
def: "A protein that is a translation product of the human RET gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PTC" RELATED Gene-based []
synonym: "RET" EXACT PRO-short-label [PRO:DNx]
synonym: "RET51" RELATED Gene-based []
synonym: "CDHF12" RELATED Gene-based []
synonym: "CDHR16" RELATED Gene-based []
synonym: "proto-oncogene c-Ret" EXACT []
synonym: "cadherin family member 12" EXACT []
xref: IUPHARobj:2185
is_a: PR:000000001 ! protein

[Term]
id: PR:P07949
name: proto-oncogene tyrosine-protein kinase receptor Ret (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07949]
comment: Category=organism-gene.
synonym: "PTC" RELATED Gene-based [UniProtKB:P07949]
synonym: "RET" RELATED Gene-based [UniProtKB:P07949]
synonym: "hRET" EXACT PRO-short-label [PRO:DNx]
synonym: "RET51" RELATED Gene-based [UniProtKB:P07949]
synonym: "CDHF12" RELATED Gene-based [UniProtKB:P07949]
synonym: "CDHR16" RELATED Gene-based [UniProtKB:P07949]
synonym: "proto-oncogene c-Ret (human)" EXACT [UniProtKB:P07949]
synonym: "cadherin family member 12 (human)" EXACT [UniProtKB:P07949]
xref: DTO:03100446
xref: UniProtKB:P07949
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret
relationship: has_gene_template HGNC:9967 ! RET (human)

[Term]
id: PR:G3V9H8
name: proto-oncogene tyrosine-protein kinase receptor Ret (rat)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of rat." [OMA:G3V9H8, PANTHER:PTHR24416:SF245, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ret" RELATED Gene-based [UniProtKB:G3V9H8]
synonym: "rRET" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:G3V9H8
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret
relationship: has_gene_template RGD:3556 ! Ret (rat)

[Term]
id: PR:000049042
name: proto-oncogene tyrosine-protein kinase receptor Ret, signal peptide removed phosphorylated 2 (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 905, 981, 1015, 1062 and 1096 of the amino acid sequence represented by UniProtKB:P07949. UniProtKB:P07949, 29-1114, Tyr-905/Tyr-981/Tyr-1015/Tyr-1062/Tyr-1096, MOD:00048." [PRO:DNx, Reactome:R-HSA-8854162]
comment: Category=organism-modification.
synonym: "hRET/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024450, Tyr-905/Tyr-981/Tyr-1015/Tyr-1062/Tyr-1096, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P07949, 29-1114, Tyr-905/Tyr-981/Tyr-1015/Tyr-1062/Tyr-1096, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8854162 "PR:000049042 located_in GO:0005886"
is_a: PR:P07949 ! proto-oncogene tyrosine-protein kinase receptor Ret (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049041
name: proto-oncogene tyrosine-protein kinase receptor Ret, signal peptide removed form (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has had the signal peptide removed. UniProtKB:P07949, 29-1114." [PRO:DNx, Reactome:R-HSA-8853797]
comment: Category=organism-modification.
synonym: "hRET/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024450" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P07949, 29-1114" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8853797 "PR:000049041 located_in GO:0005886"
intersection_of: PR:P07949 ! proto-oncogene tyrosine-protein kinase receptor Ret (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045653
name: proto-oncogene tyrosine-protein kinase receptor Ret phosphorylated 1 (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has been phosphorylated at the position equivalent to Thr-675 of the amino acid sequence represented by UniProtKB:P07949-1. Example: UniProtKB:P07949-1, Thr-675, MOD:00047." [PMID:22128160, iPTMnet:P07949]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22128160). Status=unreviewed.
synonym: "hRET/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07949-1, Thr-675, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07949 ! proto-oncogene tyrosine-protein kinase receptor Ret (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35546-2
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (mouse)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mRET/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "RET9 (mouse)" EXACT []
xref: UniProtKB:P35546-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000037460 ! proto-oncogene tyrosine-protein kinase receptor Ret isoform 2

[Term]
id: PR:P35546-1
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (mouse)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of mouse." [PMID:8455936, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mRET/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "RET51 (mouse)" EXACT []
xref: UniProtKB:P35546-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000037459 ! proto-oncogene tyrosine-protein kinase receptor Ret isoform 1

[Term]
id: PR:P07949-2
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (human)
def: "A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]
comment: Category=organism-sequence.
synonym: "hRET/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "RET9 (human)" EXACT []
xref: UniProtKB:P07949-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037460 ! proto-oncogene tyrosine-protein kinase receptor Ret isoform 2

[Term]
id: PR:000037460
name: proto-oncogene tyrosine-protein kinase receptor Ret isoform 2
def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35546-2 or a 1:1 ortholog thereof." [PMID:16141072, PRO:HJD]
comment: Category=sequence.
synonym: "RET9" EXACT []
synonym: "RET/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret