[Term]
id: PR:000050224
name: renin isoform b (human)
def: "A renin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A0A1B0GUZ2." [GenBank:AF117820, PMID:9933256, PRO:DAN]
comment: Category=organism-sequence. Note: Arises from the use of an alternative promoter within intron 1 coupled with alternative splicing and use of a downstream start codon. This is a non-secreted isoform.
synonym: "hREN/iso:b" EXACT PRO-short-label [PRO:DAN]
synonym: "renin-b (human)" EXACT [PMID:9933256]
xref: UniProtKB:A0A1B0GUZ2
is_a: PR:P00797 ! renin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00797
name: renin (human)
def: "A renin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00797]
comment: Category=organism-gene.
synonym: "REN" RELATED Gene-based [UniProtKB:P00797]
synonym: "hREN" EXACT PRO-short-label [PRO:DNx]
synonym: "angiotensinogenase (human)" EXACT [UniProtKB:P00797]
xref: UniProtKB:P00797
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013883 ! renin
relationship: has_gene_template HGNC:9958 ! REN (human)

[Term]
id: PR:000013883
name: renin
def: "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "REN" EXACT PRO-short-label [PRO:DNx]
synonym: "angiotensinogenase" RELATED []
xref: IUPHARobj:2413
is_a: PR:000050025 ! angiotensinogenase

[Term]
id: PR:000050228
name: renin isoform 1, mature form (human)
def: "A renin isoform 1, mature form in human. UniProtKB:P00797-1, 67-406." [PRO:DAN]
comment: Category=organism-modification.
synonym: "renin (human)" RELATED [PRO:DAN]
synonym: "hREN/iso:1/mature" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P00797-1, 67-406" EXACT PRO-proteoform-std [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021260 ! renin isoform 1, mature form
relationship: lacks_part SO:0000418 ! signal_peptide
relationship: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000049040
name: renin, signal peptide removed form (human)
def: "A renin (human) that has had the signal peptide removed. UniProtKB:P00797, 24-406." [PRO:DNx, Reactome:R-HSA-2065391]
comment: Category=organism-modification.
synonym: "hREN/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00797, 24-406" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2065391 "PR:000049040 located_in GO:0005886"
intersection_of: PR:P00797 ! renin (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00797-2
name: renin isoform h2 (human)
def: "A renin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00797-2." [PRO:DNx, UniProtKB:P00797]
comment: Category=organism-sequence.
synonym: "hREN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00797-2
is_a: PR:P00797 ! renin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00797-1
name: renin isoform 1 (human)
def: "A renin isoform 1 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hREN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00797-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000050221 ! renin isoform 1