[Term]
id: PR:O95398-3
name: Rap guanine nucleotide exchange factor 3 isoform h3 (human)
def: "A Rap guanine nucleotide exchange factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95398-3." [PRO:DNx, UniProtKB:O95398]
comment: Category=organism-sequence.
synonym: "hRAPGEF3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95398-3
is_a: PR:O95398 ! Rap guanine nucleotide exchange factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95398-2
name: Rap guanine nucleotide exchange factor 3 isoform h2 (human)
def: "A Rap guanine nucleotide exchange factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95398-2." [PRO:DNx, UniProtKB:O95398]
comment: Category=organism-sequence.
synonym: "hRAPGEF3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95398-2
is_a: PR:O95398 ! Rap guanine nucleotide exchange factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95398-1
name: Rap guanine nucleotide exchange factor 3 isoform h1 (human)
def: "A Rap guanine nucleotide exchange factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95398-1." [PRO:DNx, UniProtKB:O95398]
comment: Category=organism-sequence.
synonym: "hRAPGEF3/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95398-1
is_a: PR:O95398 ! Rap guanine nucleotide exchange factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000013728
name: Rap guanine nucleotide exchange factor 3
def: "A protein that is a translation product of the human RAPGEF3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EPAC" RELATED Gene-based []
synonym: "CGEF1" RELATED Gene-based []
synonym: "EPAC1" RELATED Gene-based []
synonym: "EPAC 1" EXACT []
synonym: "RAPGEF3" EXACT PRO-short-label [PRO:DNx]
synonym: "cAMP-GEFI" EXACT []
synonym: "exchange factor directly activated by cAMP 1" EXACT []
synonym: "exchange protein directly activated by cAMP 1" EXACT []
synonym: "cAMP-regulated guanine nucleotide exchange factor I" EXACT []
synonym: "Rap1 guanine-nucleotide-exchange factor directly activated by cAMP" EXACT []
xref: IUPHARobj:1292
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8VCC8-2
name: Rap guanine nucleotide exchange factor 3 isoform m2 (mouse)
def: "A Rap guanine nucleotide exchange factor 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VCC8-2." [PRO:DNx, UniProtKB:Q8VCC8]
comment: Category=organism-sequence.
synonym: "mRAPGEF3/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8VCC8-2
is_a: PR:Q8VCC8 ! Rap guanine nucleotide exchange factor 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8VCC8-1
name: Rap guanine nucleotide exchange factor 3 isoform m1 (mouse)
def: "A Rap guanine nucleotide exchange factor 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VCC8-1." [PRO:DNx, UniProtKB:Q8VCC8]
comment: Category=organism-sequence.
synonym: "mRAPGEF3/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8VCC8-1
is_a: PR:Q8VCC8 ! Rap guanine nucleotide exchange factor 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9Z1C8-2
name: Rap guanine nucleotide exchange factor 3 isoform r2 (rat)
def: "A Rap guanine nucleotide exchange factor 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1C8-2." [PRO:DNx, UniProtKB:Q9Z1C8]
comment: Category=organism-sequence.
synonym: "rRAPGEF3/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z1C8-2
is_a: PR:Q9Z1C8 ! Rap guanine nucleotide exchange factor 3 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q8VCC8
name: Rap guanine nucleotide exchange factor 3 (mouse)
def: "A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of mouse." [OMA:Q8VCC8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Epac" RELATED Gene-based [UniProtKB:Q8VCC8]
synonym: "Epac1" RELATED Gene-based [UniProtKB:Q8VCC8]
synonym: "Rapgef3" RELATED Gene-based [UniProtKB:Q8VCC8]
synonym: "mRAPGEF3" EXACT PRO-short-label [PRO:DNx]
synonym: "EPAC 1 (mouse)" EXACT [UniProtKB:Q8VCC8]
synonym: "cAMP-GEFI (mouse)" EXACT [UniProtKB:Q8VCC8]
synonym: "exchange factor directly activated by cAMP 1 (mouse)" EXACT [UniProtKB:Q8VCC8]
synonym: "exchange protein directly activated by cAMP 1 (mouse)" EXACT [UniProtKB:Q8VCC8]
synonym: "cAMP-regulated guanine nucleotide exchange factor I (mouse)" EXACT [UniProtKB:Q8VCC8]
xref: UniProtKB:Q8VCC8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013728 ! Rap guanine nucleotide exchange factor 3
relationship: has_gene_template MGI:2441741 ! Rapgef3 (mouse)

[Term]
id: PR:Q9Z1C8
name: Rap guanine nucleotide exchange factor 3 (rat)
def: "A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of rat." [OMA:Q9Z1C8, PANTHER:PTHR23113:SF24, PRO:DNx]
comment: Category=organism-gene.
synonym: "Epac" RELATED Gene-based [UniProtKB:Q9Z1C8]
synonym: "Epac1" RELATED Gene-based [UniProtKB:Q9Z1C8]
synonym: "Rapgef3" RELATED Gene-based [UniProtKB:Q9Z1C8]
synonym: "rRAPGEF3" EXACT PRO-short-label [PRO:DNx]
synonym: "EPAC 1 (rat)" EXACT [UniProtKB:Q9Z1C8]
synonym: "cAMP-GEFI (rat)" EXACT [UniProtKB:Q9Z1C8]
synonym: "exchange factor directly activated by cAMP 1 (rat)" EXACT [UniProtKB:Q9Z1C8]
synonym: "exchange protein directly activated by cAMP 1 (rat)" EXACT [UniProtKB:Q9Z1C8]
synonym: "cAMP-regulated guanine nucleotide exchange factor I (rat)" EXACT [UniProtKB:Q9Z1C8]
xref: UniProtKB:Q9Z1C8
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013728 ! Rap guanine nucleotide exchange factor 3
relationship: has_gene_template RGD:621869 ! Rapgef3 (rat)

[Term]
id: PR:Q9Z1C8-1
name: Rap guanine nucleotide exchange factor 3 isoform r1 (rat)
def: "A Rap guanine nucleotide exchange factor 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1C8-1." [PRO:DNx, UniProtKB:Q9Z1C8]
comment: Category=organism-sequence.
synonym: "rRAPGEF3/iso:r1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z1C8-1
is_a: PR:Q9Z1C8 ! Rap guanine nucleotide exchange factor 3 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:O95398
name: Rap guanine nucleotide exchange factor 3 (human)
def: "A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O95398]
comment: Category=organism-gene.
synonym: "EPAC" RELATED Gene-based [UniProtKB:O95398]
synonym: "CGEF1" RELATED Gene-based [UniProtKB:O95398]
synonym: "EPAC1" RELATED Gene-based [UniProtKB:O95398]
synonym: "RAPGEF3" RELATED Gene-based [UniProtKB:O95398]
synonym: "hRAPGEF3" EXACT PRO-short-label [PRO:DNx]
synonym: "EPAC 1 (human)" EXACT [UniProtKB:O95398]
synonym: "cAMP-GEFI (human)" EXACT [UniProtKB:O95398]
synonym: "exchange factor directly activated by cAMP 1 (human)" EXACT [UniProtKB:O95398]
synonym: "exchange protein directly activated by cAMP 1 (human)" EXACT [UniProtKB:O95398]
synonym: "cAMP-regulated guanine nucleotide exchange factor I (human)" EXACT [UniProtKB:O95398]
synonym: "Rap1 guanine-nucleotide-exchange factor directly activated by cAMP (human)" EXACT [UniProtKB:O95398]
xref: Reactome:R-HSA-3008670 "PR:O95398 located_in GO:0005886"
xref: UniProtKB:O95398
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013728 ! Rap guanine nucleotide exchange factor 3
relationship: has_gene_template HGNC:16629 ! RAPGEF3 (human)