[Term]
id: PR:000046104
name: Rap guanine nucleotide exchange factor 2 phosphorylated 1 (human)
def: "A Rap guanine nucleotide exchange factor 2 (human) that has been phosphorylated at Ser-960. UniProtKB:Q9Y4G8, Ser-960, MOD:00046." [PMID:18796635, iPTMnet:Q9Y4G8]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18796635). Status=unreviewed.
synonym: "hRAPGEF2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y4G8, Ser-960, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9Y4G8 ! Rap guanine nucleotide exchange factor 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:F1M386
name: Rap guanine nucleotide exchange factor 2 (rat)
def: "A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of rat." [OMA:F1M386, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pdzgef1" RELATED Gene-based [UniProtKB:F1M386]
synonym: "Rapgef2" RELATED Gene-based [UniProtKB:F1M386]
synonym: "rRAPGEF2" EXACT PRO-short-label [PRO:DNx]
synonym: "CNrasGEF (rat)" EXACT [UniProtKB:F1M386]
synonym: "PDZ-GEF1 (rat)" EXACT [UniProtKB:F1M386]
synonym: "RA-GEF-1 (rat)" EXACT [UniProtKB:F1M386]
synonym: "nRap GEP (rat)" EXACT [UniProtKB:F1M386]
synonym: "cyclic nucleotide ras GEF (rat)" EXACT [UniProtKB:F1M386]
synonym: "Ras/Rap1-associating GEF-1 (rat)" EXACT [UniProtKB:F1M386]
synonym: "neural RAP guanine nucleotide exchange protein (rat)" EXACT [UniProtKB:F1M386]
synonym: "PDZ domain-containing guanine nucleotide exchange factor 1 (rat)" EXACT [UniProtKB:F1M386]
xref: UniProtKB:F1M386
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013727 ! Rap guanine nucleotide exchange factor 2
relationship: has_gene_template RGD:1306434 ! Rapgef2 (rat)

[Term]
id: PR:Q8CHG7
name: Rap guanine nucleotide exchange factor 2 (mouse)
def: "A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of mouse." [OMA:Q8CHG7, PANTHER:PTHR23113:SF21, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pdzgef1" RELATED Gene-based [UniProtKB:Q8CHG7]
synonym: "Rapgef2" RELATED Gene-based [UniProtKB:Q8CHG7]
synonym: "Kiaa0313" RELATED Gene-based [UniProtKB:Q8CHG7]
synonym: "mRAPGEF2" EXACT PRO-short-label [PRO:DNx]
synonym: "CNrasGEF (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "PDZ-GEF1 (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "RA-GEF-1 (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "nRap GEP (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "cyclic nucleotide ras GEF (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "Ras/Rap1-associating GEF-1 (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "neural RAP guanine nucleotide exchange protein (mouse)" EXACT [UniProtKB:Q8CHG7]
synonym: "PDZ domain-containing guanine nucleotide exchange factor 1 (mouse)" EXACT [UniProtKB:Q8CHG7]
xref: UniProtKB:Q8CHG7
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013727 ! Rap guanine nucleotide exchange factor 2
relationship: has_gene_template MGI:2659071 ! Rapgef2 (mouse)

[Term]
id: PR:Q9Y4G8
name: Rap guanine nucleotide exchange factor 2 (human)
def: "A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y4G8]
comment: Category=organism-gene.
synonym: "NRAPGEP" RELATED Gene-based [UniProtKB:Q9Y4G8]
synonym: "PDZGEF1" RELATED Gene-based [UniProtKB:Q9Y4G8]
synonym: "RAPGEF2" RELATED Gene-based [UniProtKB:Q9Y4G8]
synonym: "KIAA0313" RELATED Gene-based [UniProtKB:Q9Y4G8]
synonym: "hRAPGEF2" EXACT PRO-short-label [PRO:DNx]
synonym: "CNrasGEF (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "PDZ-GEF1 (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "RA-GEF-1 (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "nRap GEP (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "cyclic nucleotide ras GEF (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "Ras/Rap1-associating GEF-1 (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "neural RAP guanine nucleotide exchange protein (human)" EXACT [UniProtKB:Q9Y4G8]
synonym: "PDZ domain-containing guanine nucleotide exchange factor 1 (human)" EXACT [UniProtKB:Q9Y4G8]
xref: UniProtKB:Q9Y4G8
xref: Reactome:R-HSA-5672599 "PR:Q9Y4G8 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013727 ! Rap guanine nucleotide exchange factor 2
relationship: has_gene_template HGNC:16854 ! RAPGEF2 (human)

[Term]
id: PR:000013727
name: Rap guanine nucleotide exchange factor 2
def: "A protein that is a translation product of the human RAPGEF2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RA-GEF" EXACT []
synonym: "NRAPGEP" RELATED Gene-based []
synonym: "PDZGEF1" RELATED Gene-based []
synonym: "RAPGEF2" EXACT PRO-short-label [PRO:DNx]
synonym: "CNrasGEF" EXACT []
synonym: "KIAA0313" RELATED Gene-based []
synonym: "PDZ-GEF1" EXACT []
synonym: "RA-GEF-1" EXACT []
synonym: "nRap GEP" EXACT []
synonym: "cyclic nucleotide ras GEF" EXACT []
synonym: "Ras/Rap1-associating GEF-1" EXACT []
synonym: "neural RAP guanine nucleotide exchange protein" EXACT []
synonym: "PDZ domain-containing guanine nucleotide exchange factor 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:G5EDB9-1
name: Rap guanine nucleotide exchange factor isoform a (worm)
def: "A Rap guanine nucleotide exchange factor (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EDB9-1." [PRO:DNx, UniProtKB:G5EDB9]
comment: Category=organism-sequence.
synonym: "RAPGEF2/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "Rap guanine nucleotide exchange factor isoform PXF-1-A (worm)" EXACT [UniProtKB:G5EDB9]
xref: UniProtKB:G5EDB9-1
is_a: PR:G5EDB9 ! Rap guanine nucleotide exchange factor (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:G5EDB9-2
name: Rap guanine nucleotide exchange factor isoform b (worm)
def: "A Rap guanine nucleotide exchange factor (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EDB9-2." [PRO:DNx, UniProtKB:G5EDB9]
comment: Category=organism-sequence.
synonym: "RAPGEF2/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "Rap guanine nucleotide exchange factor isoform PXF-1-B (worm)" EXACT [UniProtKB:G5EDB9]
xref: UniProtKB:G5EDB9-2
is_a: PR:G5EDB9 ! Rap guanine nucleotide exchange factor (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:G5EDB9-3
name: Rap guanine nucleotide exchange factor isoform d (worm)
def: "A Rap guanine nucleotide exchange factor (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EDB9-3." [PRO:DNx, UniProtKB:G5EDB9]
comment: Category=organism-sequence.
synonym: "RAPGEF2/iso:d (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "Rap guanine nucleotide exchange factor isoform PXF-1-C (worm)" EXACT [UniProtKB:G5EDB9]
xref: UniProtKB:G5EDB9-3
is_a: PR:G5EDB9 ! Rap guanine nucleotide exchange factor (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:G5EDB9
name: Rap guanine nucleotide exchange factor (worm)
def: "A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of worm." [OMA:G5EDB9, PRO:DNx]
comment: Category=organism-gene.
synonym: "pxf-1" RELATED Gene-based [UniProtKB:G5EDB9]
synonym: "ra-gef" RELATED Gene-based [UniProtKB:G5EDB9]
synonym: "T14G10.2" RELATED Gene-based [UniProtKB:G5EDB9]
synonym: "RA-GEF (worm)" EXACT [UniProtKB:G5EDB9]
synonym: "RAPGEF2 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "PDZ-domain-containing exchange factor (worm)" EXACT [UniProtKB:G5EDB9]
xref: UniProtKB:G5EDB9
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000013727 ! Rap guanine nucleotide exchange factor 2
relationship: has_gene_template WormBase:WBGene00004254 ! pxf-1 (worm)