[Term]
id: PR:Q6QI68-1
name: gamma-secretase subunit PEN-2 isoform 1 (rat)
def: "A gamma-secretase subunit PEN-2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPSENEN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q6QI68-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000043676 ! gamma-secretase subunit PEN-2 isoform 1

[Term]
id: PR:Q8JHF0
name: gamma-secretase subunit PEN-2 (zebrafish)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of zebrafish." [OMA:Q8JHF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "pen2" RELATED Gene-based [UniProtKB:Q8JHF0]
synonym: "psenen" RELATED Gene-based [UniProtKB:Q8JHF0]
synonym: "z-PSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "zgc:109727" RELATED Gene-based [UniProtKB:Q8JHF0]
synonym: "presenilin enhancer protein 2 homolog (zebrafish)" EXACT [UniProtKB:Q8JHF0]
xref: UniProtKB:Q8JHF0
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template ZFIN:ZDB-GENE-040218-1 ! psenen (zebrafish)

[Term]
id: PR:Q9FY84
name: probable gamma-secretase subunit PEN-2 (Arabidopsis thaliana)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of Arabidopsis thaliana." [PANTHER:PTHR16318:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "At-PSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "At5g09310" RELATED Gene-based [UniProtKB:Q9FY84]
xref: UniProtKB:Q9FY84
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template Araport:AT5G09310 ! At5g09310 (Arabidopsis thaliana)

[Term]
id: PR:Q86BE9
name: gamma-secretase subunit pen-2 (fruit fly)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of fruit fly." [OMA:Q86BE9, PANTHER:PTHR16318:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "pen-2" RELATED Gene-based [UniProtKB:Q86BE9]
synonym: "CG33198" RELATED Gene-based [UniProtKB:Q86BE9]
synonym: "fly-PSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2 (fruit fly)" EXACT [UniProtKB:Q86BE9]
xref: UniProtKB:Q86BE9
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template FlyBase:FBgn0053198 ! pen-2 (fruit fly)

[Term]
id: PR:Q9CQR7-1
name: gamma-secretase subunit PEN-2 isoform 1 (mouse)
def: "A gamma-secretase subunit PEN-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPSENEN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9CQR7-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000043676 ! gamma-secretase subunit PEN-2 isoform 1

[Term]
id: PR:Q9NZ42
name: gamma-secretase subunit PEN-2 (human)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NZ42]
comment: Category=organism-gene.
synonym: "PEN2" RELATED Gene-based [UniProtKB:Q9NZ42]
synonym: "MDS033" RELATED Gene-based [UniProtKB:Q9NZ42]
synonym: "PSENEN" RELATED Gene-based [UniProtKB:Q9NZ42]
synonym: "hPSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2 (human)" EXACT [UniProtKB:Q9NZ42]
xref: UniProtKB:Q9NZ42
xref: Reactome:R-HSA-157331 "PR:Q9NZ42 located_in GO:0005886"
xref: Reactome:R-HSA-9010101 "PR:Q9NZ42 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template HGNC:30100 ! PSENEN (human)

[Term]
id: PR:Q9CQR7
name: gamma-secretase subunit PEN-2 (mouse)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of mouse." [OMA:Q9CQR7, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pen2" RELATED Gene-based [UniProtKB:Q9CQR7]
synonym: "Psenen" RELATED Gene-based [UniProtKB:Q9CQR7]
synonym: "mPSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2 (mouse)" EXACT [UniProtKB:Q9CQR7]
xref: UniProtKB:Q9CQR7
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template MGI:1913590 ! Psenen (mouse)

[Term]
id: PR:000043676
name: gamma-secretase subunit PEN-2 isoform 1
def: "A gamma-secretase subunit PEN-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZ42-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PSENEN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013346 ! gamma-secretase subunit PEN-2

[Term]
id: PR:Q9NZ42-1
name: gamma-secretase subunit PEN-2 isoform 1 (human)
def: "A gamma-secretase subunit PEN-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPSENEN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NZ42-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000043676 ! gamma-secretase subunit PEN-2 isoform 1

[Term]
id: PR:000036245
name: gamma-secretase subunit PEN-2 acetylated 1 (mouse)
def: "A gamma-secretase subunit PEN-2 (mouse) that is N-terminal Met acetylated. UniProtKB:Q9CQR7, Met-1, MOD:00058." [TDR:8786]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "mPSENEN/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9CQR7, Met-1, MOD:00058" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:8786
is_a: PR:Q9CQR7 ! gamma-secretase subunit PEN-2 (mouse)
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q6QI68
name: gamma-secretase subunit PEN-2 (rat)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of rat." [OMA:Q6QI68, PANTHER:PTHR16318:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Psenen" RELATED Gene-based [UniProtKB:Q6QI68]
synonym: "rPSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2 (rat)" EXACT [UniProtKB:Q6QI68]
synonym: "liver regeneration-related protein LRRGT00140 (rat)" EXACT [UniProtKB:Q6QI68]
xref: UniProtKB:Q6QI68
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template RGD:1312037 ! Psenen (rat)

[Term]
id: PR:000013346
name: gamma-secretase subunit PEN-2
def: "A protein that is a translation product of the human PSENEN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "PEN2" RELATED Gene-based []
synonym: "MDS033" RELATED Gene-based []
synonym: "PSENEN" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9U357
name: gamma-secretase subunit pen-2 (worm)
def: "A gamma-secretase subunit PEN-2 that is encoded in the genome of worm." [OMA:Q9U357, PANTHER:PTHR16318:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "pen-2" RELATED Gene-based [UniProtKB:Q9U357]
synonym: "T28D6.9" RELATED Gene-based [UniProtKB:Q9U357]
synonym: "PSENEN (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "presenilin enhancer protein 2 (worm)" EXACT [UniProtKB:Q9U357]
xref: UniProtKB:Q9U357
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000013346 ! gamma-secretase subunit PEN-2
relationship: has_gene_template WormBase:WBGene00003975 ! pen-2 (worm)

[Term]
id: PR:Q8JHF0-1
name: gamma-secretase subunit PEN-2 isoform 1 (zebrafish)
def: "A gamma-secretase subunit PEN-2 isoform 1 that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "z-PSENEN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8JHF0-1
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000043676 ! gamma-secretase subunit PEN-2 isoform 1