[Term]
id: PR:000036890
name: presenilin-2 isoform 1 CTF subunit (mouse)
def: "A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]
comment: Category=organism-modification. Although generated by different means, this form is (by sequence) identical to PR:000036858 presenilin-2 isoform PS2short (mouse).
synonym: "PS2s" RELATED [PMID:9353287]
synonym: "PRO_0000025608" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mPSEN2/iso:1/Clv:CTF" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q61144-1, 298-448" BROAD PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036889 ! presenilin-2 isoform 1 CTF subunit

[Term]
id: PR:000036891
name: PS2s (mouse)
def: "A presenilin-2 (mouse) that results from either translation of an alternative short PS2 transcript or by proteolysis of PS2 isoform 1. Example: UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]
comment: Category=union.
synonym: "mPS2s" EXACT PRO-short-label [PRO:DAN]
synonym: "presenilin-2 short" RELATED [PMID:9353287]
is_a: PR:Q61144 ! presenilin-2 (mouse)
union_of: PR:000036858 ! presenilin-2 isoform PS2short (mouse)
union_of: PR:000036890 ! presenilin-2 isoform 1 CTF subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61144
name: presenilin-2 (mouse)
def: "A presenilin-2 that is encoded in the genome of mouse." [OMA:Q61144, PRO:CNA]
comment: Category=organism-gene.
synonym: "Ad4h" RELATED Gene-based [UniProtKB:Q61144]
synonym: "Alg3" RELATED Gene-based [UniProtKB:Q61144]
synonym: "Ps-2" RELATED Gene-based [UniProtKB:Q61144]
synonym: "Psen2" RELATED Gene-based [UniProtKB:Q61144]
synonym: "Psnl2" RELATED Gene-based [UniProtKB:Q61144]
synonym: "mPSEN2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61144
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013345 ! presenilin-2
relationship: has_gene_template MGI:109284 ! Psen2 (mouse)

[Term]
id: PR:000036858
name: presenilin-2 isoform PS2short (mouse)
def: "A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]
comment: Category=organism-sequence. Although generated by different means, this form is (by sequence) identical to PR:000036890 presenilin-2 isoform 1 CTF subunit (mouse).
synonym: "PS2s" RELATED [PMID:9353287]
synonym: "mPSEN2/iso:PS2short" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q61144-1, 298-448" BROAD PRO-proteoform-std [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036857 ! presenilin-2 isoform PS2short

[Term]
id: PR:000036888
name: presenilin-2 isoform 1 N-terminal fragment (mouse)
def: "A presenilin-2 isoform 1 N-terminal fragment in mouse. UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:KRC]
comment: Category=organism-modification. Note: Cleaved by caspase-3.
synonym: "PS2Ncas" BROAD [PMID:9353287]
synonym: "mPSEN2/iso:1/Clv:Nter" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q61144-1, 1-329" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036887 ! presenilin-2 isoform 1 N-terminal fragment

[Term]
id: PR:Q61144-2
name: presenilin-2 isoform PS2beta (mouse)
def: "A presenilin-2 isoform PS2beta that is encoded in the genome of mouse. The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA." [PMID:19376115, PRO:KRC]
comment: Category=organism-sequence. Evidence=This isoform has been seen endogeneously in microsomal fraction from mouse brain.
synonym: "mPSEN2/iso:PS2beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61144-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036853 ! presenilin-2 isoform PS2beta

[Term]
id: PR:000013345
name: presenilin-2
def: "A protein that is a translation product of the human PSEN2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "AD4" RELATED Gene-based []
synonym: "AD5" EXACT []
synonym: "PS2" RELATED Gene-based []
synonym: "Ad4h" RELATED Gene-based []
synonym: "Alg3" RELATED Gene-based []
synonym: "E5-1" EXACT []
synonym: "PS-2" EXACT []
synonym: "STM2" RELATED Gene-based []
synonym: "AD3LP" EXACT []
synonym: "PSEN2" EXACT PRO-short-label [PRO:DNx]
synonym: "PSNL2" RELATED Gene-based []
synonym: "STM-2" EXACT []
xref: IUPHARobj:2403
is_a: PR:000000001 ! protein

[Term]
id: PR:000036886
name: presenilin-2 isoform 1 C-terminal fragment (mouse)
def: "A presenilin-2 isoform 1 C-terminal fragment in mouse. UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:KRC]
comment: Category=organism-modification. Note: Cleaved by caspase-3.
synonym: "PS2Ccas" BROAD [PMID:9353287]
synonym: "mPSEN2/iso:1/Clv:Cter" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q61144-1, 330-448" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036881 ! presenilin-2 isoform 1 C-terminal fragment

[Term]
id: PR:Q61144-1
name: presenilin-2 isoform 1 (mouse)
def: "A presenilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:19376115, PRO:KRC]
comment: Category=organism-sequence.
synonym: "mPSEN2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61144-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000036851 ! presenilin-2 isoform 1