[Term]
id: PR:P54646
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P54646]
comment: Category=organism-gene.
synonym: "AMPK" RELATED Gene-based [UniProtKB:P54646]
synonym: "AMPK2" RELATED Gene-based [UniProtKB:P54646]
synonym: "PRKAA2" RELATED Gene-based [UniProtKB:P54646]
synonym: "hPRKAA2" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (human)" BROAD [UniProtKB:P54646]
synonym: "HMGCR kinase (human)" BROAD [UniProtKB:P54646]
synonym: "AMPK subunit alpha-2 (human)" EXACT [UniProtKB:P54646]
synonym: "acetyl-CoA carboxylase kinase (human)" BROAD [UniProtKB:P54646]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (human)" BROAD [UniProtKB:P54646]
xref: Reactome:R-HSA-200405 "PR:P54646 located_in GO:0005829"
xref: Reactome:R-HSA-163682 "PR:P54646 located_in GO:0005654"
xref: DTO:03100005
xref: UniProtKB:P54646
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2
relationship: has_gene_template HGNC:9377 ! PRKAA2 (human)

[Term]
id: PR:P54646-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKAA2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P54646-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039760 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1

[Term]
id: PR:Q8BRK8
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of mouse." [OMA:Q8BRK8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Prkaa2" RELATED Gene-based [UniProtKB:Q8BRK8]
synonym: "mPRKAA2" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (mouse)" RELATED [UniProtKB:Q8BRK8]
synonym: "HMGCR kinase (mouse)" RELATED [UniProtKB:Q8BRK8]
synonym: "AMPK subunit alpha-2 (mouse)" EXACT [UniProtKB:Q8BRK8]
synonym: "acetyl-CoA carboxylase kinase (mouse)" RELATED [UniProtKB:Q8BRK8]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (mouse)" RELATED [UniProtKB:Q8BRK8]
xref: UniProtKB:Q8BRK8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2
relationship: has_gene_template MGI:1336173 ! Prkaa2 (mouse)

[Term]
id: PR:Q09137-2
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform Short (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q09137-2." [PRO:DNx, UniProtKB:Q09137]
comment: Category=organism-sequence.
synonym: "rPRKAA2/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09137-2
is_a: PR:Q09137 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q09137-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform Long (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q09137-1." [PRO:DNx, UniProtKB:Q09137]
comment: Category=organism-sequence.
synonym: "rPRKAA2/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09137-1
is_a: PR:Q09137 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000039760
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54646-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PRKAA2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2

[Term]
id: PR:Q09137
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of rat." [OMA:Q09137, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ampk" RELATED Gene-based [UniProtKB:Q09137]
synonym: "Ampk2" RELATED Gene-based [UniProtKB:Q09137]
synonym: "Prkaa2" RELATED Gene-based [UniProtKB:Q09137]
synonym: "rPRKAA2" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (rat)" EXACT [UniProtKB:Q09137]
synonym: "HMGCR kinase (rat)" EXACT [UniProtKB:Q09137]
synonym: "AMPK subunit alpha-2 (rat)" EXACT [UniProtKB:Q09137]
synonym: "acetyl-CoA carboxylase kinase (rat)" EXACT [UniProtKB:Q09137]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (rat)" EXACT [UniProtKB:Q09137]
xref: UniProtKB:Q09137
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2
relationship: has_gene_template RGD:620893 ! Prkaa2 (rat)

[Term]
id: PR:000056642
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 N-glycosylated 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 (human) that has been N-glycosylated at the residue equivalent to Asn-388 of the amino acid sequence represented by UniProtKB:P54646-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P54646-1, Asn-388, MOD:00160~GNO:G00912UN." [GlyGen:P54646-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPRKAA2/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P54646-1, Asn-388, MOD:00160~GNO:G00912UN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P54646 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 (human)
relationship: has_part GNO:G00912UN ! G00912UN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046198
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 in rat. Example: UniProtKB:Q09137-1, Thr-172, MOD:00047." [PMID:10642499, PMID:8910387, PRO:LN, iPTMnet:Q09137]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8910387). Evidence=(ECO:0000006, based on PMID:10642499).
synonym: "rPRKAA2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q09137-1, Thr-172, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049964 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1
disjoint_from: PR:Q09137-2 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform Short (rat)
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000048902
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 in human. UniProtKB:P54646, Thr-172, MOD:00047." [PRO:DNx, Reactome:R-HSA-164171, Reactome:R-HSA-200417]
comment: Category=organism-modification.
synonym: "hPRKAA2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P54646, Thr-172, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-200417 "PR:000048902 located_in GO:0005829"
xref: Reactome:R-HSA-164171 "PR:000048902 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049964 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049964
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that has been phosphorylated at the position equivalent to Thr-172 of the amino acid sequence represented by UniProtKB:P54646. Example: UniProtKB:P54646, Thr-172, MOD:00047." [PMID:10642499, PMID:23842676PMID:8910387, Reactome:R-HSA-164171, Reactome:R-HSA-200417, iPTMnet:Q09137]
comment: Category=modification.
synonym: "PRKAA2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK (Thr(172))" RELATED [PMID:23842676]
is_a: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049965
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that lacks phosphorylation at the position equivalent to Thr-172 of the amino acid sequence represented by UniProtKB:P54646. Example: UniProtKB:P54646, Thr-172, PR:000026291." [PRO:CNA]
comment: Category=modification.
synonym: "PRKAA2/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013219 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2

[Term]
id: PR:000049966
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in human. UniProtKB:P54646, Thr-172, PR:000026291." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hPRKAA2/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P54646, Thr-172, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049965 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1

[Term]
id: PR:Q8BRK8-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPRKAA2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BRK8-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039760 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1

[Term]
id: PR:000013219
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2
def: "A protein that is a translation product of the human PRKAA2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AMPK" RELATED Gene-based []
synonym: "AMPK2" RELATED Gene-based []
synonym: "PRKAA2" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK subunit alpha-2" EXACT []
xref: IUPHARobj:1542
is_a: PR:000000001 ! protein

[Term]
id: PR:000049961
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in rat. Example: UniProtKB:Q09137-1, Thr-172, PR:000026291." [PMID:10642499, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10642499).
synonym: "rPRKAA2/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q09137-1, Thr-172, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049965 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1
disjoint_from: PR:Q09137-2 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform Short (rat)

[Term]
id: PR:000049962
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 in mouse. UniProtKB:Q8BRK8, Thr-172, MOD:00047." [PMID:23842676, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23842676).
synonym: "mPRKAA2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK (Thr(172))" RELATED [PMID:23842676]
synonym: "UniProtKB:Q8BRK8, Thr-172, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049964 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049963
name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in mouse. UniProtKB:Q8BRK8, Thr-172, PR:000026291." [PMID:23842676, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23842676).
synonym: "mPRKAA2/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8BRK8, Thr-172, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049965 ! 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1