[Term]
id: PR:000012836
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
def: "A phospholipase C-gamma that is a translation product of the human PLCG1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PLC1" RELATED Gene-based []
synonym: "PLCG1" EXACT PRO-short-label [PRO:DNx]
synonym: "PLC-II" EXACT []
synonym: "Plcg-1" RELATED Gene-based []
synonym: "PLC-148" EXACT []
synonym: "PLC-gamma-1" EXACT []
synonym: "phospholipase C-II" EXACT []
synonym: "phospholipase C-gamma-1" EXACT []
synonym: "phosphoinositide phospholipase C-gamma-1" EXACT []
xref: IUPHARobj:1407
is_a: PR:000050049 ! phospholipase C-gamma

[Term]
id: PR:P19174-2
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform h2 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19174-2." [PRO:DNx, UniProtKB:P19174]
comment: Category=organism-sequence.
synonym: "hPLCG1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19174-2
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045701
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 phosphorylated 1 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has been phosphorylated at the position equivalent to Tyr-783 of the amino acid sequence represented by UniProtKB:P19174-1. Example: UniProtKB:P19174-1, Tyr-783, MOD:00048." [PMID:17148460, iPTMnet:P19174]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17148460). Status=unreviewed.
synonym: "hPLCG1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19174-1, Tyr-783, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19174-1
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform h1 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19174-1." [PRO:DNx, UniProtKB:P19174]
comment: Category=organism-sequence.
synonym: "hPLCG1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19174-1
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19174
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19174]
comment: Category=organism-gene.
synonym: "PLC1" RELATED Gene-based [UniProtKB:P19174]
synonym: "PLCG1" RELATED Gene-based [UniProtKB:P19174]
synonym: "hPLCG1" EXACT PRO-short-label [PRO:DNx]
synonym: "PLC-II (human)" EXACT [UniProtKB:P19174]
synonym: "PLC-148 (human)" EXACT [UniProtKB:P19174]
synonym: "PLC-gamma-1 (human)" EXACT [UniProtKB:P19174]
synonym: "phospholipase C-II (human)" EXACT [UniProtKB:P19174]
synonym: "phospholipase C-gamma-1 (human)" EXACT [UniProtKB:P19174]
synonym: "phosphoinositide phospholipase C-gamma-1 (human)" EXACT [UniProtKB:P19174]
xref: UniProtKB:P19174
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012836 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
relationship: has_gene_template HGNC:9065 ! PLCG1 (human)

[Term]
id: PR:000048804
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, initiator methionine removed phosphorylated 4 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 771, 783 and 1253 of the amino acid sequence represented by UniProtKB:P19174. UniProtKB:P19174, 2-1290, Tyr-771/Tyr-783/Tyr-1253, MOD:00048." [PRO:DNx, Reactome:R-HSA-202357]
comment: Category=organism-modification.
synonym: "hPLCG1/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088498, Tyr-771/Tyr-783/Tyr-1253, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P19174, 2-1290, Tyr-771/Tyr-783/Tyr-1253, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202357 "PR:000048804 located_in GO:0005829"
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048805
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, initiator methionine removed phosphotyrosine form (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has had the initiator methionine removed and that includes at least one phosphorylated tyrosine. UniProtKB:P19174, 2-1290, MOD:00048." [PRO:DNx, Reactome:R-HSA-593686]
comment: Category=organism-modification.
synonym: "hPLCG1/InitMet-/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088498, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P19174, 2-1290, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-593686 "PR:000048805 located_in GO:0005886"
xref: Reactome:R-HSA-9029082 "PR:000048805 located_in GO:0005829"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048801
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, initiator methionine removed form (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has had the initiator methionine removed. UniProtKB:P19174, 2-1290." [PRO:DNx, Reactome:R-HSA-167682, Reactome:R-HSA-202320]
comment: Category=organism-modification.
synonym: "PRO_0000088498" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPLCG1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19174, 2-1290" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202320 "PR:000048801 located_in GO:0005829"
xref: Reactome:R-HSA-167682 "PR:000048801 located_in GO:0005886"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048802
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, initiator methionine removed phosphorylated 2 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 472, 771, 783 and 1253 of the amino acid sequence represented by UniProtKB:P19174. UniProtKB:P19174, 2-1290, Tyr-472/Tyr-771/Tyr-783/Tyr-1253, MOD:00048." [PRO:DNx, Reactome:R-HSA-167679]
comment: Category=organism-modification.
synonym: "hPLCG1/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088498, Tyr-472/Tyr-771/Tyr-783/Tyr-1253, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P19174, 2-1290, Tyr-472/Tyr-771/Tyr-783/Tyr-1253, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-167679 "PR:000048802 located_in GO:0005886"
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048803
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, initiator methionine removed phosphorylated 3 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 771 and 783 of the amino acid sequence represented by UniProtKB:P19174. UniProtKB:P19174, 2-1290, Tyr-771/Tyr-783, MOD:00048." [PRO:DNx, Reactome:R-HSA-1169084]
comment: Category=organism-modification.
synonym: "hPLCG1/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088498, Tyr-771/Tyr-783, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P19174, 2-1290, Tyr-771/Tyr-783, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1169084 "PR:000048803 located_in GO:0005886"
is_a: PR:P19174 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine