[Term]
id: PR:000012826
name: urokinase-type plasminogen activator
def: "A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "uPA" EXACT []
synonym: "PLAU" EXACT PRO-short-label [PRO:DNx]
synonym: "U-plasminogen activator" EXACT []
xref: IUPHARobj:2393
is_a: PR:000000001 ! protein

[Term]
id: PR:000048797
name: urokinase-type plasminogen activator, signal peptide removed form (human)
def: "A urokinase-type plasminogen activator (human) that has had the signal peptide removed. UniProtKB:P00749, 21-431." [PRO:DNx, Reactome:R-HSA-158945, Reactome:R-HSA-158979]
comment: Category=organism-modification.
synonym: "hPLAU/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000028318" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P00749, 21-431" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-158945 "PR:000048797 located_in GO:0005886"
xref: Reactome:R-HSA-158979 "PR:000048797 located_in GO:0005576"
xref: Reactome:R-HSA-6799705 "PR:000048797 located_in GO:0035579"
xref: Reactome:R-HSA-6800974 "PR:000048797 located_in GO:0070821"
intersection_of: PR:P00749 ! urokinase-type plasminogen activator (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00749-2
name: urokinase-type plasminogen activator isoform h2 (human)
def: "A urokinase-type plasminogen activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00749-2." [PRO:DNx, UniProtKB:P00749]
comment: Category=organism-sequence.
synonym: "hPLAU/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00749-2
is_a: PR:P00749 ! urokinase-type plasminogen activator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00749-1
name: urokinase-type plasminogen activator isoform 1 (human)
def: "A urokinase-type plasminogen activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00749-1." [PRO:DNx, UniProtKB:P00749]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPLAU/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00749-1
is_a: PR:P00749 ! urokinase-type plasminogen activator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051248
name: urokinase-type plasminogen activator N-glycosylated 1 (human)
def: "A urokinase-type plasminogen activator (human) that has been N-glycosylated at the residue equivalent to Asn-322 of the amino acid sequence represented by UniProtKB:P00749-1, in which the glycan structure is represented by GlyTouCan:G23626NI. Example: UniProtKB:P00749-1, Asn-322, MOD:00160~GNO:G23626NI." [GlyGen:P00749-1, PMID:1468573, PMID:2023947, PMID:2393398, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPLAU/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00749-1, Asn-322, MOD:00160~GNO:G23626NI" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P00749-1, Asn-322, MOD:00160~UniCarbKB:1037" NARROW [PRO:DNx]
is_a: PR:P00749 ! urokinase-type plasminogen activator (human)
relationship: has_part GNO:G23626NI ! G23626NI
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051249
name: urokinase-type plasminogen activator N-glycosylated 2 (human)
def: "A urokinase-type plasminogen activator (human) that has been N-glycosylated at the residue equivalent to Asn-322 of the amino acid sequence represented by UniProtKB:P00749-1, in which the glycan structure is represented by GlyTouCan:G86102AA. Example: UniProtKB:P00749-1, Asn-322, MOD:00160~GNO:G86102AA." [GlyGen:P00749-1, PMID:1468573, PMID:2023947, PMID:2393398, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPLAU/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00749-1, Asn-322, MOD:00160~GNO:G86102AA" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P00749-1, Asn-322, MOD:00160~UniCarbKB:1035" NARROW [PRO:DNx]
is_a: PR:P00749 ! urokinase-type plasminogen activator (human)
relationship: has_part GNO:G86102AA ! G86102AA
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00749
name: urokinase-type plasminogen activator (human)
def: "A urokinase-type plasminogen activator that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00749]
comment: Category=organism-gene.
synonym: "PLAU" RELATED Gene-based [UniProtKB:P00749]
synonym: "hPLAU" EXACT PRO-short-label [PRO:DNx]
synonym: "uPA (human)" EXACT [UniProtKB:P00749]
synonym: "U-plasminogen activator (human)" EXACT [UniProtKB:P00749]
xref: UniProtKB:P00749
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012826 ! urokinase-type plasminogen activator
relationship: has_gene_template HGNC:9052 ! PLAU (human)